Benefit of Clopidogrel over Aspirin Is Amplified in Patients with a History of Ischemic Events

Stroke

Volumn 35, Issue 2, 2004, Pages 528-532

  Ringleb, Peter A ^a   Bhatt, Deepak L ^c   Hirsch, Alan T ^b   Topol, Eric J ^c   Hacke, Werner ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Aspirin; Clopidogrel; Patients; Randomized controlled trials

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HEART INFARCTION; HIGH RISK POPULATION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; VASCULAR DISEASE;

AGED; ARTERIOSCLEROSIS; ASPIRIN; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; DATABASES, FACTUAL; FEMALE; HOSPITALIZATION; HUMANS; MALE; MYOCARDIAL INFARCTION; PLATELET AGGREGATION INHIBITORS; PROPORTIONAL HAZARDS MODELS; RANDOMIZED CONTROLLED TRIALS; RECURRENCE; RISK; SURVIVAL RATE; TICLOPIDINE; TREATMENT OUTCOME;

EID: 0842310777     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000110221.54366.49     Document Type: Article

References (16)

1. Nenci GG. Unifying concept of arterial vascular disease. Eur Heart J. 1999;1(suppl A):A27-A30.
2. 2000 Heart and Stroke Statistical Update. Dallas, Tex: American Heart Association; 1999.
3. Topol EJ. Toward a new frontier in myocardial reperfusion therapy: emerging platelet pre-eminence. Circulation. 1998;97:211-218.
4. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971;231:232-235.
5. Gent M. The CAPRIE trial: culmination of the preregistration program for clopidogrel. Semin Thromb Hemost. 1999;25(suppl 2):1-2.
6. CAPRIE Steering Committee. A randomised, blinded, trial of Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE). Lancet. 1996;348:1329-1339.
7. Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy, I: prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ. 1994;308:81-106.
8. Blecic S. Atherothrombotic events often indicate disseminated atherosclerosis: data from CAPRIE. Cerebrovasc Div. 1998;8(suppl 3):34. Abstract.
9. Harker LA, Boissel J-P, Pilgrim AJ, Gent M, for the CAPRIE Steering Committee. Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. Drug Safety. 1999;21:325-335.
10. Moloney BA. An analysis of the side effects of ticlopidine. In: Hass WK, Easton JD, eds. Ticlopidine, Platelets and Vascular Disease. New York, NY: Springer-Verlag; 1993:117-139.
11. Bhatt DL, Hirsch AT, Ringleb PA, Hacke W, Topol EJ, for the CAPRIE Investigators. Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin: CAPRIE investigators. Am Heart J. 2000;140:67-73.
12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
13. Laupacis A, Sackett DL, Roberts RS. An assessment of clinically useful measures of the consequences of treatment. N Engl J Med. 1992;92: 121-124.
14. Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK, for the Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001; 345:494-502.
15. Bhatt DL, Chew DP, Hirsch AT, Ringleb P, Hacke W, Topol EJ. Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery. Circulation. 2001;103:363-368.
16. Bhatt DL, Marso SP, Hirsch AT, Ringleb P, Hacke W, Topol EJ. Amplified benefit of clopidogrel versus aspirin in patients with a history of diabetes mellitus. Am J Cardiol. 2002;90:625-628.