Resistance to Signal Activation Governs Design Features of the MAP Kinase Signaling Module

Biotechnology and Bioengineering

Volumn 85, Issue 3, 2004, Pages 311-322

  Chapman, Stephen ^a   Asthagiri, Anand R ^a  

^a California Institute of Technology   (United States)

Author keywords

Biocircuit; Mathematical modeling; Phosphatase; Systems biology

Indexed keywords

AMPLIFICATION; CELLS; ENZYME KINETICS; PROTEINS; SIGNALING;

MITOGEN-ACTIVATED PROTEINS (MAP); SIGNAL ACTIVATION;

BIOTECHNOLOGY;

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; PHOSPHOTRANSFERASE;

ARTICLE; CELL FUNCTION; CHEMICAL ENGINEERING; ENZYME ACTIVATION; ENZYME ACTIVITY; MATHEMATICAL MODEL; PLEIOTROPY; PREDICTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

COMPUTER SIMULATION; GENE EXPRESSION REGULATION; HOMEOSTASIS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MULTIENZYME COMPLEXES; PROTEIN ENGINEERING; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS);

EID: 0842300395     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10836     Document Type: Article

References (27)

1. Alon U, Surette M, Barkai N, Leibler S. 1999. Robustness in bacterial chemotaxis. Nature 397:168-171.
2. Arkin A, Ross J. 1994. Computational functions in biochemical reaction networks. Biophys J 67:560-578.
3. Asthagiri A, Lauffenburger D. 2000. Bioengineering models of cell signaling. Annu Rev Biomed Eng 2:31-53.
4. Asthagiri A, Lauffenburger D. 2001. A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model. Biotech Prog 17:227-239.
5. Barkai N, Leibler S. 1997. Robustness in simple biochemical networks. Nature 387:913-917.
6. Bhalla U, Ram P, Iyengar R. 2002. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297:1018-1023.
7. Brown G, Hoek J, Kholodenko B. 1997. Why do protein kinase cascades have more than one level? TIBS 22:288.
8. Davis R. 2000. Signal transduction by the JNK group of MAP kinases. Cell 103:239-252.
9. Endy D, Brent R. 2001. Modelling cellular behaviour. Nature 409:391-395.
10. Ferrell J. 1996. Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs. TIBS 21:460-466.
11. Ferrell J. 1997. How responses get more switch-like as you move down a protein kinase cascade. TIBS 22:288-289.
12. Huang C.-Y, Ferrell J. 1996. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 93:10078-10083.
13. Kao S.-C, Jaiswal R, Kolch W, Landreth G. 2001. Identification of the mechanisms regulating the differential activation of the MAPK cascade by epidermal growth factor and nerve growth factor in PC12 cells. J Biol Chem 276:18169-18177.
14. Keyse S. 2000. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Op Cell Biol 12:186-192.
15. Levchenko A, Bruck J, Sternberg P. 2000. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc Natl Acad Sci USA 97:5818-5823.
16. Lewis T, Shapiro P, Ahn N. 1998. Signal transduction through MAP kinase cascades. Adv Cancer Res 74:49-139.
17. Marshall C. 1995. Specificity of receptor tyrsosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
18. Pages G, Lenormand P, Allemain G, Chambar J.-C, Meloche S, Pouyssegur J. 1993. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc Natl Acad Sci USA 90:8319-8323.
19. Park S.-H, Zarrinpar A, Lim W. 2003. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299:1061-1064.
20. Pearson G, Robinson F, Gibson T, Xu B.-E, Karandikar M, Berman K, Cobb M. 2001. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr Rev 22:153-183.
21. Roulston A, Reinhard C, Amiri P, Williams L. 1998. Early activation of c-jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor α. J Biol Chem 273:10232-10239.
22. Saxena M, Mustelin T. 2000. Extracellular signals and scores of phosphatases: All roads lead to MAP kinase. Semin Immunol 12:387-396.
23. Scheele J, Rhee J, Boss G. 1995. Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: Comparison of parental and Ras-overproducing NIH 3T3 fibroblasts. Proc Natl Acad Sci USA 92:1097-1100.
24. Schoeberl B, Eichler-Johnsson C, Gilles E, Muller G. 2002. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat Biotech 20:370-375.
25. Tamura S, Hanada M, Ohnishi M, Katsura K, Sasaki M, Kobayashi T. 2002. Regulation of stress-activated protein kinase signaling pathways by protein phosphatases. Eur J Biochem 269:1060-1066.
26. Tyson J, Chen K, Novak B. 2001. Network dynamics and cell physiology. Nat Rev Mol Cell Biol 2:908-916.
27. Yi T.-M, Huang Y, Simon M, Doyle J. 2000. Robust perfect adaptation in bacterial chernotaxis through integral feedback control. Proc Natl Acad Sci USA 97:4649-4653.