Inhibition of Adenosine Deaminase by Novel 5:7 Fused Heterocycles Containing the Imidazo[4,5-e][1,2,4]triazepine Ring System: A Structure-Activity Relationship Study

Journal of Medicinal Chemistry

Volumn 47, Issue 4, 2004, Pages 1044-1050

  Reayi, Ayub ^a   Hosmane, Ramachandra S ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROIMIDAZOLE; 7,8 DIHYDRO 1 (4 METHOXYBENZYL) 8 (2 METHOXYETHOXY) 6H 6,7 DIMETHYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE; 7,8 DIHYDRO 1 (4 METHOXYBENZYL) 8 (3 METHYLBENZYLOXY) 6H 6,7 DIMETHYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE; 7,8 DIHYDRO 1 (4 METHOXYBENZYL) 8 (4 METHOXYBENZYLOXY) 6H 6,7 DIMETHYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE; 7,8 DIHYDRO 1 [4 METHOXYBENZYL] 6H 6,7 DIMETHYL 8 PROPOXYIMIDAZO[4,5 E][1,2,4]TRIAZEPINE; 7,8 DIHYDRO 8 ETHOXY 1 (4 METHOXYBENZYL) 6H 6,7 DIMETHYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE; 7,8 DIHYDRO 8 ISOPROPOXY 1 (4 METHOXYBENZYL) 6H 6,7 DIMETHYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE; 7,8 DIHYDRO 8 METHOXY 1 (4 METHOXYBENZYL) 6H 6,7 DIMETHYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE; 8 BUTOXY 7,8 DIHYDRO 1 (4 METHOXYBENZYL) 6H 6,7 DIMETHYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE; ADENOSINE DEAMINASE; ADENOSINE DEAMINASE INHIBITOR; ALCOHOL; COFORMYCIN; IMIDAZO[4,5 E][1,2,4]TRIAZEPINE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; KINETICS; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ADENOSINE DEAMINASE; ANIMALS; AZEPINES; CATTLE; HYDROLYSIS; IMIDAZOLES; KINETICS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0842282711     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0304257     Document Type: Article

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