Tear clearance implications for ocular surface health

Experimental Eye Research

Volumn 78, Issue 3, 2004, Pages 395-397

  De Paiva, Cintia Sade ^a   Pflugfelder, Stephen C ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CULLEN EYE INSTITUTE   (United States)

Author keywords

Dry eye; Epitheliopathy; Inflammation; Tear clearance; Tear turnover

Indexed keywords

ANTIINFLAMMATORY AGENT;

CLEARANCE; CLINICAL EXAMINATION; CORNEA DISEASE; CORNEA EPITHELIUM; DISEASE SEVERITY; DRY EYE; EYE INFLAMMATION; EYE IRRITATION; FLUOROPHOTOMETRY; FUNCTIONAL ASSESSMENT; HUMAN; LACRIMAL DUCT; LACRIMAL FLUID; OPHTHALMOLOGY; PRIORITY JOURNAL; REVIEW; SCHIRMER TEST; STANDARDIZATION; TEAR CLEARANCE; TEAR FILM; VISUAL SYSTEM;

EID: 0842267112     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2003.08.003     Document Type: Article

References (21)

1. Afonso A.A., Monroy D., Stern M.E., Feuer W.J., Tseng S.C., Pflugfelder S.C. Correlation of tear fluorescein clearance and Schirmer test scores with ocular irritation symptoms. Ophthalmology. 106:1999;803-810.
2. Afonso A.A., Sobrin L., Monroy D.C., Selzer M., Lokeshwar B., Pflugfelder S.C. Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Invest. Ophthalmol. Vis. Sci. 40:1999;2506-2512.
3. Asahi M., Wang X., Mori T., Sumii T., Jung J.C., Moskowitz M.A., Fini M.E., Lo E.H. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J. Neurosci. 21:2001;7724-7732.
4. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med. 332:1995;1351-1362.
5. Doane M.G. Interactions of eyelids and tears in corneal wetting and the dynamics of the normal human eye blink. Am. J. Ophthalmol. 89:1980;507-516.
6. Dursun D., Wang M., Monroy D., Li D.Q., Lokeshwar B.L., Stern M.E., Pflugfelder S.C. A mouse model of keratoconjunctivitis sicca. Invest. Ophthalmol. Vis. Sci. 43:2002;632-638.
7. Eter N., Gobbels M. A new technique for tear film fluorophotometry. Br. J. Ophthalmol. 86:2002;616-619.
8. Fibbe W.E., Daha M.R., Hiemstra P.S., Duinkerken N., Lurvink E., Ralph P., Altrock B.W., Kaushansky K., Willemze R., Falkenburg J.H. Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. Exp. Hematol. 17:1989;229-234.
9. Joshi A., Maurice D., Paugh J.R. A new method for determining corneal epithelial barrier to fluorescein in humans. Invest. Ophthalmol. Vis. Sci. 37:1996;1008-1016.
10. Li D.-Q., Lokeshwar B.L., Solomon A., Monroy D., Ji Z., Pflugfelder S.C. Regulation of MMP-9 production by human corneal epithelial cells. Exp. Eye Res. 73:2001;449-459.
11. Li D.-Q., Shang T.Y., Kim H.S., Solomon A., Lokeshwar B.L., Pflugfelder S.C. Regulated expression of collagenases MMP-1, -8, -13 and stromelysins MMP-3, -10, -11 by human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 44:2003;2928-2936.
12. Macri A., Pflugfelder S.C. Correlation of the Schirmer 1 and fluorescein clearance tests with the severity of corneal epithelial and eyelid disease. Arch. Ophthalmol. 118:2000;1632-1638.
13. Macri A., Rolando M., Pflugfelder S.C. A standardized visual scale for evaluation of tear fluorescein clearance. Ophthalmology. 107:2000;1338-1343.
14. Nelson J.D. Simultaneous evaluation of tear turnover and corneal epithelial permeability by fluorophotometry in normal subjects and patients with keratoconjunctivitis sicca (KCS). Trans. Am. Ophthalmol. Soc. 93:1995;709-753.
15. Pflugfelder S.C., Farley W., Li D.-Q., Song X., Fini E. Matrix metalloproteinase-9 (MMP-9) knockout alters the ocular surface response to experimental dryness. Invest. Ophthalmol. Vis. Sci. 43:2002;3124. E-Abstract.
16. Prabhasawat P., Tseng S.C. Frequent association of delayed tear clearance in ocular irritation. Br. J. Ophthalmol. 82:1998;666-675.
17. Stern M.E., Beuerman R.W., Fox R.I., Gao J., Mircheff A.K., Pflugfelder S.C. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 17:1998;584-589.
18. Sternlicht M.D., Werb Z. How matrix metalloproteinases regulate cell behavior. Ann. Rev. Cell Dev. Biol. 17:2001;463-516. Review.
19. Solomon A., Dursun D., Liu Z., Xie Y., Macri A., Pflugfelder S.C. Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest. Ophthalmol. Vis. Sci. 42:2001;2283-2292.
20. Solomon A., Rosenblatt M., Li D., Monroy D., Ji Z., Lokeshwar B.L., Pflugfelder S.C. Doxycycline inhibition of interleukin-1 in the corneal epithelium. Am. J. Ophthalmol. 130:2000;688.
21. Tsubota K., Kaido M., Yagi Y., Fujihara T., Shimmura S. Diseases associated with ocular surface abnormalities: the importance of reflex tearing. Br. J. Ophthalmol. 83:1999;89-91.