Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons

Journal of Computational Neuroscience

Volumn 16, Issue 1, 2004, Pages 5-13

  Migliore, M ^a,b   Messineo, L ^b,c   Ferrante, M ^b,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CNR   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

Author keywords

CA1; Dendritic integration; Ih; Modeling

Indexed keywords

BRAIN;

BRAIN REGIONS; CA1; CA1 PYRAMIDAL NEURON; DENDRITIC INTEGRATION; DENDRITICS; IH; INPUT-OUTPUT PROPERTIES; MODELING; REALISTIC MODEL; TEMPORAL SUMMATION;

NEURONS;

ARTICLE; CELL SPECIFICITY; CELL SYNCHRONIZATION; COMPUTER MODEL; CONTROLLED STUDY; DENDRITE; EXCITATORY POSTSYNAPTIC POTENTIAL; HYPERPOLARIZATION ACTIVATED CURRENT; ION CURRENT; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE CONDUCTANCE; NEUROMODULATION; PREDICTION; PRIORITY JOURNAL; PROBABILITY; PYRAMIDAL NERVE CELL; SPIKE; TEMPORAL SUMMATION; ANIMAL; BIOLOGICAL MODEL; COMPARATIVE STUDY; COMPUTER SIMULATION; CYTOLOGY; DRUG EFFECT; HIPPOCAMPUS; NERVE CONDUCTION; PHYSIOLOGY; REPRODUCIBILITY; SYNAPTIC TRANSMISSION; TIME;

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; N METHYLASPARTIC ACID;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; COMPUTER SIMULATION; DENDRITES; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; MODELS, NEUROLOGICAL; N-METHYLASPARTATE; NEURAL CONDUCTION; PROBABILITY; PYRAMIDAL CELLS; REPRODUCIBILITY OF RESULTS; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 0842264748     PISSN: 09295313     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JCNS.0000004837.81595.b0     Document Type: Article

References (33)

1. Andrasfalvy BK, Magee JC (2001) Distance-dependent increase in AMPA receptor number in the dendrites of adult hippocampal CA1 pyramidal neurons. J. Neurosci. 21: 9151-9159.
2. Bilkey DK, Schwartzkroin PA (1990) Variation in electrophysiology and morphology of hippocampal CA3 pyramidal cells. Brain Res. 514: 77-83.
3. Brewster A, Bender RA, Chen Y, Dube C, Eghbal-Ahmadi M, Baram TZ (2002) Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J. Neurosci. 22: 4591-4599.
4. Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I (2001) Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat. Med. 7: 331-337.
5. Chrobak JJ, Buzsáki G (1998) Gamma oscillations in the Entorhinal Cortex of the freely behaving rat. J. Neurosci. 18: 388-398.
6. Destexhe A, Mainen ZF, Sejnowski TJ (1994) An efficient method for computing synaptic conductances based on a kinetic model of receptor binding. Neural Comp. 6: 10-14.
7. Destexhe A, Pare D (1999) Impact of network activity on the integrative properties of neocortical pyramidal neurons in vivo. J. Neurophysiol. 81: 1531-1547.
8. Dickson CT, Mena AR, Alonso A (1997) Electroresponsiveness of medial entorhinal cortex layer III neurons in vitro. Neuroscience 81: 937-950.
9. Frank LM, Brown EN, Wilson MA (2001) A comparison of the firing properties of putative excitatory and inhibitory neurons from CA1 and the entorhinal cortex. J. Neurophysiol. 86: 2029-2040.
10. Hines M, Carnevale T (1997) The NEURON simulation environment. Neural Comp. 9: 178-1209.
11. Hoffman DA, Magee JC, Colbert CM, Johnston D (1997) K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387: 869-875.
12. Ho N, Destexhe A (2000) Synaptic background activity enhances the responsiveness of neocortical pyramidal neurons. J. Neurophysiol. 84: 1488-1496.
13. Jahr CE, Stevens CF (1990) A quantitative description of NMDA receptor-channel kinetic behavior. J. Neurosci. 10: 1830-1837.
14. Jahr CE, Stevens CF (1990b) Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics. J. Neurosci. 10: 3178-3182.
15. Johnston D, Amaral DG (1998) Hippocampus In: GM Shepherd, ed. The Synaptic Organization of the Brain, 4th ed. Oxford Univ. Press, New York, pp. 417-458.
16. Luthi A, McCormick DA (1999) Modulation of a pacemaker current through Ca(2+)-induced stimulation of cAMP production. Nat. Neurosci. 2: 634-641.
17. Magee JC (1998) Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J. Neurosci. 18: 7613-7624.
18. Magee JC (1999) Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons. Nat Neurosci. 2: 508-514.
19. Magee JC, Cook E (2000) Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature Neurosci. 3: 895-903.
20. Megias M, Emri Z, Freund TF, Gulyas AI (2001) Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. Neuroscience 102: 527-540.
21. Migliore M (2003) On the integration of subthreshold inputs from Perforant Path and Schaffer collaterals in hippocampal CA1 neurons. J. Comput. Neurosci. 14: 185-192.
22. Migliore M, Hoffman DA, Magee JC, Johnston D (1999) Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. J. Comput. Neurosci. 7: 5-16.
23. Migliore M, Shepherd GM (2002) Emerging rules for the distributions of active dendritic conductances. Nature Rev. Neurosci. 3: 362-370.
24. Penny WD, Kiebel SJ, Kilner JM, Rugg MD (2002) Event-related brain dynamics. Trends Neurosci. 25: 387-389.
25. Poolos NP, Migliore M, Johnston D (2002) Pharmacological upregulation of h-channels selectively reduces the excitability of pyramidal neuron dendrites. Nature Neurosci. 5: 767-774.
26. Spruston N, Schiller Y, Stuart G, Sakmann B (1995) Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science 268: 297-300.
27. Stricker C, Field AC, Redman SJ (1996) Statistical analysis of amplitude fluctuations in EPSCs evoked in rat CA1 pyramidal neurones in vitro. J. Physiol. 490: 419-441.
28. Suzuki SS, Smith GK (1985) Burst characteristics of hippocampal complex spike cells in the awake rat. Exp. Neurol. 89: 90-95.
29. Traub RD, Whittington MA, Colling SB, Buzsaki G, Jefferys JG (1996) Analysis of gamma rhythms in the rat hippocampus in vitro and in vivo. J. Physiol. 493: 471-484.
30. h) in cultured rat olfactory receptor neurons. J. Membr. Biol. 188: 115-125.
31. h in mouse hippocampal pyramidal neurons. J. Neurosci. 22: 8992-9004.
32. + channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons. Proc. Natl. Acad. Sci. USA 99: 8366-8371.
33. Williams SR, Stuart GJ (2000) Site independence of EPSP time course is mediated by dendritic I(h) in neocortical pyramidal neurons. J Neurophysiol 83: 3177-3182.