Histopathological safety evaluation of polyethylene glycol applied subcutaneously in mice

Journal of International Medical Research

Volumn 32, Issue 1, 2004, Pages 66-69

  Kawakami, T ^a   Mizoguchi, T ^a   Matsuura, S ^a   Shimizu, T ^a   Kurihara, S ^a   Ito, M ^a   Kawai, T ^b  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Polyethylene glycol; Propylene glycol; Safety evaluation; Tissue response

Indexed keywords

BIOMATERIAL; MACROGOL; ROOT CANAL FILLING MATERIAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSAFETY; CONTROLLED STUDY; FOREIGN BODY REACTION; GRANULATION TISSUE; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; INJECTION SITE; MALE; MOUSE; NONHUMAN; TISSUE DEGENERATION; TISSUE NECROSIS;

EID: 0742324818     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000403200111     Document Type: Article

References (9)

1. Lee CC, Anderson RC: Toxicologic studies on vancomycin and polyethylene glycol 200. Toxicol Appl Pharmacol 1962; 4: 206 - 214.
2. Lockard JS, Levy RH, Congdon WC, DuCharme LL: Efficacy and toxicity of the solvent polyethylene glycol 400 in monkey model. Epilepsia 1979; 20: 77 - 84.
3. Lockard JS, Levy RH: Polyethylene glycol 400: solvent and anticonvulsant? Life Sci 1978; 23: 2499 - 2502.
4. Carpenter CP, Woodside MD, Kinkead ER, King JM, Sullivan LJ: Response of dogs to repeated intravenous injection of polyethylene glycol 4000 with notes on excretion and sensitization. Toxicol Appl Pharmacol 1971; 18: 35 - 40.
5. Nishio T, Hirota S, Yamashita J, Kobayashi K, Motohashi Y, Kato Y: Erythrocyte changes in aqueous polyethylene glycol solutions containing soduim chloride. J Pharm Sci 1982; 71: 977 - 979.
6. Fort FL, Heyman IA, Kesterson JW: Hemolysis study of aqueous polyethylene glycol 400, propylene glycol and ethanol combinations in vivo and in vitro. J Parenter Sci Technol 1984; 38: 82 - 87.
7. Dodd MC, Hartmann FW, Ward WC: Surface-active agents as ointment bases. J Am Pharm Assoc Sci Ed 1946; 35: 33 - 41.
8. International Organization for Standardization (ISO): Biological Evaluation of Medical Devices - Part 6: Tests for Local Effects after Implantation (ISO 10993-6:1994). Geneva, Switzerland: ISO, 1994.
9. Kawakami T, Takei N, Antoh H, Hasegawa H, Kise T, Eda S: A histopathological evaluation of safety of squalane fluid applied subcutaneously. Med Sci Res 1995; 23: 521 - 523.