EBV Kidney Allograft Infection: Possible Relationship with a Peri-Graft Localization of PTLD

American Journal of Transplantation

Volumn 4, Issue 1, 2004, Pages 116-123

  Cosio, Fernando G ^a   Nuovo, Margaret ^a   Delgado, Lazaro ^a   Yearsley, Martha ^a   Porcu, Pierluigi ^a   Caligiuri, Michael ^a   Pelletier, Ronald P ^a   Nuovo, Gerard J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

EBV; Infection; Kidney; Lymphoma; PTLD; Transplantation

Indexed keywords

COMPLEMENT COMPONENT C3D RECEPTOR; VIRUS DNA; VIRUS RNA;

ADULT; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; EPSTEIN BARR VIRUS; FEMALE; GENE CONTROL; GRAFT INFECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY ALLOGRAFT; KIDNEY PROXIMAL TUBULE; LYMPHOCYTE PROLIFERATION; LYMPHOPROLIFERATIVE DISEASE; MALE; NONHUMAN; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER; PRIORITY JOURNAL;

ADULT; AGED; B-LYMPHOCYTES; BIOPSY; CELL DIVISION; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY; KIDNEY TRANSPLANTATION; LYMPHOCYTES; LYMPHOMA; MALE; MIDDLE AGED; RECEPTORS, COMPLEMENT 3D; RNA; TIME FACTORS;

EID: 0742318924     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1600-6143.2003.00309.x     Document Type: Article

References (27)

1. Opelz G, Henderson R. Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients. Lancet 1993; 342: 1514-1516.
2. Dharnidharka VR, Sullivan EK, Stablein DM, Tejani AH, Harmon WE. Risk factors for posttransplant lymphoproliferative disorder (PTLD) in pediatric kidney transplantation: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Transplantation 2001; 71: 1065-1068.
3. Swinnen LJ. Transplantation-related lymphoproliferative disorder: a model for human immunodeficiency virus-related lymphomas. Semin Oncol 2000; 27: 402-408.
4. Paya CV, Fung JJ, Nalesnik MA et al. Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. Transplantation 1999; 68: 1517-1525.
5. Okano M, Gross TG. From Burkitt's lymphoma to chronic active Epstein-Barr virus (EBV) infection: an expanding spectrum of EBV-associated diseases. Pediatr Hematol Oncol 2001; 18: 427-442.
6. Preiksaitis JK, Diaz-Mitoma F, Mirzayans F, Roberts S, Tyrrell DL. Quantitative oropharyngeal Epstein-Barr virus shedding in renal and cardiac transplant recipients: relationship to immunosuppressive therapy, serologic responses, and the risk of posttransplant lymphoproliferative disorder. J Infect Dis 1992; 166: 986-994.
7. Lee S, Kjellstrand CM. Renal disease in infectious mononucleosis. Clin Nephrol 1978; 9: 236-240.
8. Becker JL, Miller F, Nuovo GJ, Josepovitz C, Schubach WH, Nord EP. Epstein-Barr virus infection of renal proximal tubule cells: possible role in chronic interstitial nephritis. J Clin Invest 1999; 104: 1673-1681.
9. Frade R, Barel M, Ehlin-Henriksson B, Klein G. gp140, the C3d receptor of human B lymphocytes, is also the Epstein-Barr virus receptor. Proc Natl Acad Sci USA 1985; 82: 1490-1493.
10. Nickeleit V, Hirsch HH, Binet IF et al. J. Polyomavirus infection of renal allograft recipients: from latent infection to manifest disease. J Am Soc Nephrol 1999; 10: 1080-1089.
11. Nickeleit V, Klimkait T, Binet IF et al. Testing for polyornavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy [see comments]. N Engl J Med 2000; 342: 1309-1315.
12. Cosio FG, Pesavento TE, Osei K, Henry ML, Ferguson RM. Post-transplant diabetes mellitus: Increasing incidence in renal allograft recipients transplanted in recent years. Kidney Int 2001; 59: 732-737.
13. Nuovo G. PCR in situ Hybridization. Protocols and Applications, 3rd edn. Philadelphia, New York: Lippincott-Raven Publishers; 2002.
14. Racusen LC, Solez K, Colvin RB et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713-723.
15. Porcu P, Eisenberg D, Pelletier RP et al. Successful treatment of post-transplant lymphoproliferative disorder (PTLD) following renal allografting is associated with sustained CD8+ T-cell restoration. Blood 2002; 100: 2341-2348.
16. Haque T, Thomas JA, Falk KI et al. Transmission of donor Epstein-Barr virus (EBV) in transplanted organs causes lymphoproliferative disease in EBV-seronegative recipients. J Gen Virol 1996; 77: 1169-1172.
17. Arnout MA, Colten HR. Complement C3 receptors: structural function. Mol Immunol 1984; 1191: 1199-1199.
18. Garcia Aguilar J, Brown GE, Lanser MW. Coagulation increases neutrophil CR1 and CR3 expression: primary role for platelet-derived growth factor. J Lab Clin Med 1989; 114: 312-320.
19. Wang F, Gregory C, Sample C et al. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 co-operatively induce CD23. J Virol 1990; 64: 2309-2318.
20. Kibota Y, Gaither TA, Cason J, O'Shea JJ, Lawley TJ. Characterization of the C3 receptor induced by herpes simplex virus type 1 infection of human epidermal, endothelial and A431 cells. J Immunol 1987; 138: 1137-1142.
21. Frade R. Structure and functions of gp140, the C3d/EBV receptor (CR2) of human B lymphocytes. Mol Immunol 1986; 23: 1241-1153.
22. Hatzfeld A, Fischer E, Levesque J-P, Perrin R, Hatzfeld J, Kazatchkine MD. Binding of C3 and C3dg to the CR2 complement receptor induces growth of an Epstein-Barr virus positive human B cell line. J Immunol 1988; 140: 170-175.
23. Kogan-Liberman D, Burroughs M, Emre S, Moscona A, Shneider BL. The role of quantitative Epstein-Barr virus polymerase chain reaction and preemptive immunosuppression reduction in pediatric liver transplantation: a preliminary experience. J Pediatr Gastroenterol Nutr 2001; 33: 445-449.
24. Kenagy DN, Schlesinger Y, Weck K, Ritter JH, Gaudreault-Keener MM, Storch GA. Epstein-Barr virus DNA in peripheral blood leukocytes of patients with posttransplant lymphoproliferative disease. Transplantation 1995; 60: 547-554.
25. Wakely P, Menezes G, Nuovo G. Primary effusion lymphoma: Cytologic diagnosis using in situ molecular genetic analysis for human herpes virus 8. Mod Pathol 2002; 15: 944-950.
26. Miller WT, Jr, Siegel SG, Montone KT. Posttransplantation lymphoproliferative disorder: changing manifestations of disease in a renal transplant population. Crit Rev Diagn Imaging 1997; 38: 569-585.
27. Nuovo GJ, Becker J, Burk MW, Margiotta M, Fuhrer J, Steigbigel RT. In situ detection of PCR-amplified HIV-1 nucleic acids in lymph nodes and peripheral blood in patients with asymptomatic HIV-1 infection and advanced-stage AIDS. J Acquir Immune Defic Syndr 1994; 7: 916-923.