A Prospective, Randomized Pilot Evaluation of Topical Triple Antibiotic Versus Mupirocin for the Prevention of Uncomplicated Soft Tissue Wound Infection

American Journal of Emergency Medicine

Volumn 22, Issue 1, 2004, Pages 1-3

  Hood, Robert ^a   Shermock, Kenneth M ^a   Emerman, Charles ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Antibiotic therapy; Infection; Prophylaxis; Wound care

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BACITRACIN; NEOMYCIN; NEOSPORIN; POLYMYXIN B; PSEUDOMONIC ACID;

ADULT; ARTICLE; BACTERIAL INFECTION; CHI SQUARE DISTRIBUTION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTACT DERMATITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG COMBINATION; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG SAFETY; ERYTHEMA; FEMALE; FOLLOW UP; HUMAN; MALE; NONPARAMETRIC TEST; OINTMENT; PARESTHESIA; PATIENT COMPLIANCE; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RASH; SIDE EFFECT; SOFT TISSUE INFECTION; SUTURING METHOD; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME; TYPES OF STUDY; WOUND CARE; WOUND DRESSING; WOUND INFECTION;

EID: 0742288239     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajem.2003.09.009     Document Type: Article

References (22)

1. Gosnold J: Infection rate of sutured wounds. Practitioner 1977; 218:584-585
2. Hutton P, Jones B, Law D: Depot penicillin as prophylaxis in accidental wounds. Br J Surg 1978;65:549-550
3. Rutherford W, Spence R: Infection in wounds sutured in the accident and emergency department. Ann Emerg Med 1980;9:350-352
4. Thirlby R, Blair A, Thal E: The value of prophylactic antibiotics for simple lacerations. Surg Gynecol Obstet 1983;156:212-216
5. Dire D, Coppola M, Dwyer D, Lorette J, Karr J: A prospective evaluation of topical antibiotics for uncomplicated soft-tissue lacerations. Acad Emerg Med 1995;2:4-10
6. Ealls L, Mertz P, Piovanetti Y, Pekoe G: An evaluation of the safety and efficacy of topical antimicrobial therapy for primary skin infections. J Invest Dermatol 1984;82:404
7. Hogan P: Pediatric dermatology: impetigo. Aust Fam Physician 1998;27:735-736
8. Bass J, Chan D, Creamer K, et al: Comparison of oral cephalexin, topical mupirocin and topical bacitracin for treatment of impetigo. Pediatr Infect Dis J 1997;16:708-710
9. Hudson I: The efficacy of intranasal mupirocin in the presentation of staphylococcal infections: a review of recent experience. J Hosp Infect 1994;27:81-98
10. Livingstone V, Stringer L: The treatment of Staphylococcus aureus infected nipples: a randomized study. Journal of Human Lactation 1999;15:241-246
11. Drummond MF, O'Brien B, Stoddart GL, Torrance GW: Methods for the Economic Evaluation of Health Care Programmes, 2nd ed. Oxford: Oxford Medical Publications; 1997
12. Langford J, Artemi P, Berimoj S: Topical antimicrobial prophylaxis in minor wounds. Ann Pharmacother 1997;31:559-563
13. MacDonald R, Beck M: Neomycin: a review with particular reference to dermatological usage. Clin Exp Dermatol 1983;8:249-258
14. Johnson C: Hearing loss following the application of topical neomycin. J Burn Care Rehabil 1988;9:162-164
15. Kelly D, Nilo E, Berggren R: Deafness after topical neomycin wound irrigation. N Engl J Med 1969;280:1338-1339
16. Prystowsky S, Allen A, Smith R, et al: Allergic contact hypersensitivity to nickel, neomycin, ethylenediamine, and benzocaine. Arch Dermatol 1979;115:959-962
17. Prystowsky S, Nonomura J, Smith R, et al: Allergic hypersensitivity to neomycin: relationship between patch test reactions and "use" tests. Arch Dermatol 1979;115:713-715
18. Booth J, Benrimoj S, Nimmo G: In vitro interactions of neomycin sulfate, bacitracin, and polymyxin B sulfate. Int J Dermatol 1994;33:517-520
19. Hendley J, Ashe K: Effect of topical antimicrobial treatment on aerobic bacteria in the stratum corneum of human skin. Antimicrob Agents Chemother 1991;35:627-631
20. Davis S, Cazzaniga A, Mertz P: Can OTC Antimicrobial Bandages Reduce Staphylococcus aureus in Partial Thickness Wounds? American Academy of Dermatology Poster Exhibit; Feb 2, 1992; New Orleans, LA.
21. Zappi E, Brancaccio R: Allergic contact dermatitis from mupirocin ointment. J Am Acad Dermatol 1997;36:266
22. Bactroban Product Information. Philadelphia: SmithKline Beecham; 1999