The genetics of schizophrenia: Chromosomal deletions, attentional disturbances, and spectrum boundaries

American Journal of Psychiatry

Volumn 160, Issue 9, 2003, Pages 1549-1553

  Kendler, Kenneth S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENTION DEFICIT DISORDER; CHROMOSOME 22Q; CHROMOSOME DELETION; DIGEORGE SYNDROME; DISEASE ASSOCIATION; EDITORIAL; GENE IDENTIFICATION; GENE REPLICATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; INTERVIEW; MOLECULAR GENETICS; MOOD DISORDER; ONSET AGE; PERSONALITY DISORDER; PREVALENCE; PRIORITY JOURNAL; SCHIZOPHRENIA; TRISOMY 21; VELOCARDIOFACIAL SYNDROME; ADOPTION; ADULT; CHILD; CHROMOSOME 22; FEMALE; GENE DELETION; GENETICS; MALE; NOTE; PHENOTYPE; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER; STARTLE REFLEX;

ADOPTION; ADULT; CHILD; CHILD OF IMPAIRED PARENTS; CHROMOSOMES, HUMAN, PAIR 22; FEMALE; GENE DELETION; HUMANS; MALE; MOOD DISORDERS; PHENOTYPE; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER; STARTLE REACTION;

EID: 0642343936     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.9.1549     Document Type: Editorial

References (32)

1. Rudin E: Studien uber Vererbung und entstehung geistiger Storungen, I: Zur vererbung und neuentstehung der Dementia praecox (Studies on the Inheritance and Origin of Mental Illness, I: The Problem of the Inheritance and Primary Origin of Dementia Praecox): Monographien aus dem Gesamtgebiet der Neurologie und Psychiatrie, Number 12. Berlin, Springer, 1916
2. Kendler KS, Zerbin-Rudin E: Abstract and review of "Studien uber Vererbung und Entstehung geistiger Storungen, I: Zur Vererbung und Neuentstehung der dementia praecox." Am J Med Genet Neuropsychiatr Genet 1996; 67:338-342
3. Liu H, Heath SC, Sobin C, Roos JL, Galke BL, Blundell ML, Lenane M, Robertson B, Wijsman EM, Rapoport JL, Gogos JA, Karayiorgou M: Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc Natl Acad Sci USA 2002; 99:3717-3722
4. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, et al: Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 2002; 99:13675-13680; correction, 99:17221
5. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, et al: Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 2002; 71:877-892
6. Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, Cesare AJ, Gibberman A, Wang X, O'Neill FA, Walsh D, Kendler KS: Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet 2002; 71:337-348
7. Stefansson H, Sarginson J, Kong A, Yates P, Steinthorsdottir V, Gudfinnsson E, Gunnarsdottir S, Walker N, Petursson H, Crombie C, Ingason A, Gulcher JR, Stefansson K, St Clair D: Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am J Hum Genet 2003; 72:83-87
8. Schwab SG, Knapp M, Mondabon S, Hallmayer J, Borrmann-Hassenbach M, Albus M, Lerer B, Rietschel M, Trixler M, Maier W, Wildenauer DB: Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am J Hum Genet 2003; 72:185-190
9. Schulz B: Zur Erbpathologie der Schizophrenie (On the hereditary pathology of schizophrenia). Z Gesamte Neurol Psychiatrie 1932; 143:175-293
10. Kendler KS, Zerbin-Rudin E: Abstract and review of "Zur erbpathologie der Schizophrenie." Am J Med Genet Neuropsychiatr Genet 1996; 67:343-346
11. Kendler KS, Davis KL: The genetics and biochemistry of paranoid schizophrenia and other paranoid psychoses. Schizophr Bull 1981; 7:689-709
12. Kendler KS, Gruenberg AM, Tsuang MT: A family study of the subtypes of schizophrenia. Am J Psychiatry 1988; 145:57-62
13. Ungvari G: Validity of the ICD-9 schizophrenia classification: a blind family history study. Acta Psychiatr Scand 1983; 68:287-296
14. Kendler KS, McGuire M, Gruenberg AM, Walsh D: Outcome and family study of the subtypes of schizophrenia in the west of Ireland. Am J Psychiatry 1994; 151:849-856
15. Murphy KC, Jones LA, Owen MJ: High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 1999; 56:940-945
16. Gothelf D, Frisch A, Munitz H, Rockah R, Laufer N, Mozes T, Hermesh H, Weizman A, Frydman M: Clinical characteristics of schizophrenia associated with velo-cardio-facial syndrome. Schizophr Res 1999; 35:105-112
17. Bassett AS, Chow EW: 22q11 deletion syndrome: a genetic subtype of schizophrenia. Biol Psychiatry 1999; 46:882-891
18. Delisi LE, Reiss AL, White BJ, Gershon ES: Cytogenetic studies of males with schizophrenia: screening for the fragile X chromosome and other chromosomal abnormalities. Schizophr Res 1988; 1:277-281
19. Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, Clair DM, Muir WJ, Blackwood DH, Porteous DJ: Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 2000; 9:1415-1423
20. MacIntyre DJ, Blackwood DH, Porteous DJ, Pickard BS, Muir WJ: Chromosomal abnormalities and mental illness. Mol Psychiatry 2003; 8:275-287
21. Kety SS, Rosenthal D, Wender PH, Schulsinger F: The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. J Psychiatr Res 1968; 6:345-362
22. Kety SS, Wender P, Jacobsen B, Ingraham LJ, Jansson L, Faber B, Kinney DK: Mental illness in the biological and adoptive relatives of schizophrenic adoptees: replication of the Copenhagen study in the rest of Denmark. Arch Gen Psychiatry 1994; 51:442-455
23. Zerbin-Rudin E, Kendler KS: Ernst Rudin and his genealogic-demographic department in Munich: an introduction to their family studies of schizophrenia. Am J Med Genet Neuropsychiatr Genet 1996; 67:332-337
24. Baron M, Gruen R, Rainer JD, Kane J, Asnis L, Lord S: A family study of schizophrenic and normal control probands: implications for the spectrum concept of schizophrenia. Am J Psychiatry 1985; 142:447-455
25. Maier W, Minges J, Lichtermann D, Heun R, Franke P: Personality variations in healthy relatives of schizophrenics. Schizophr Res 1994; 12:81-88
26. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D: The Roscommon Family Study, III: schizophrenia-related personality disorders in relatives. Arch Gen Psychiatry 1993; 50:781-788
27. Kendler KS, Gardner CO Jr: The risk for psychiatric disorders in relatives of schizophrenic and control probands: a comparison of three independent studies. Psychol Med 1997; 27:411-419
28. Kendler KS: Schizophrenia: genetics, in Kaplan and Sadock's Comprehensive Textbook of Psychiatry, 7th ed. Edited by Sadock BJ, Sadock VA. New York, Williams & Wilkins, 2000, pp 1147-1158
29. Asarnow RF, Nuechterlein KH, Fogelson D, Subotnik KL, Payne DA, Russell AT, Asamen J, Kuppinger H, Kendler KS: Schizophrenia and schizophrenia-spectrum personality disorders in the first-degree relatives of children with schizophrenia: the UCLA Family Study. Arch Gen Psychiatry 2001; 58:581-588
30. Weissman MM, Fink M, Endicott J, Taylor MA, Kendler KS, Winokur G, Gershon ES: Discussion of debate: is there a genetic Kraepelinian dichotomy for manic-depressive illness and schizophrenia? in Genetic Approaches to Mental Disorders. Edited by Gershon ES, Cloninger CR. Washington, DC, American Psychiatric Press, 1994, pp 193-202
31. Berrettini WH: Are schizophrenic and bipolar disorders related? a review of family and molecular studies. Biol Psychiatry 2000; 48:531-538
32. Harrison PJ, Owen MJ: Genes for schizophrenia? recent findings and their pathophysiological implications. Lancet 2003; 361:417-419