Phosphocreatine restores high-energy phosphates in ischemic myocardium: Implication for off-pump cardiac revascularization

Journal of the American College of Surgeons

Volumn 197, Issue 5, 2003, Pages 786-791

  Prabhakar, Ganga ^a   Vona Davis, Linda ^a   Murray, David ^a   Lakhani, Paresh ^a   Murray, Gordon ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; PHOSPHATE; DIAGNOSTIC AGENT; PHOSPHORUS;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; ENERGY CONSUMPTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REVASCULARIZATION; HIGH ENERGY PHOSPHATE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; OFF PUMP CORONARY SURGERY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PREMEDICATION; PRIORITY JOURNAL; RAT; SHAM FEEDING; SPECIES COMPARISON; ANIMAL; CHEMISTRY; CORONARY BLOOD VESSEL; DISEASE MODEL; DRUG EFFECT; DRUG SCREENING; ENERGY METABOLISM; GLYCOLYSIS; HEART INFARCTION PREVENTION; HEART MUSCLE; HEART MUSCLE REPERFUSION; INTRAVENOUS DRUG ADMINISTRATION; LIGATION; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; TIME;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANIMALS; CORONARY VESSELS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENERGY METABOLISM; GLYCOLYSIS; INJECTIONS, INTRAVENOUS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; LIGATION; MAGNETIC RESONANCE IMAGING; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; PHOSPHATES; PHOSPHOCREATINE; PHOSPHORUS ISOTOPES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0642310841     PISSN: 10727515     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jamcollsurg.2003.05.001     Document Type: Article

References (22)

1. Saks V.A., Kuznetsov A.V., Kupriyanov V.V., et al. Creatine kinase of rat heart mitochondria. The demonstration of functional coupling to oxidative phosphorylation in an inner membrane-matrix preparation. J Biol Chem. 260:1985;7757-7764.
2. Wallimann T., Wyss M., Brdiczka D., et al. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands the 'phosphocreatine circuit' for cellular energy homeostasis . Biochem J. 281:1992;21-40.
3. Sharov V.G., Saks V.A., Kupriyanov V.V., et al. Protection of ischemic myocardium by exogenous phosphocreatine. I. Morphologic and phosphorus 31-nuclear magnetic resonance studies. J Thorac Cardiovasc Surg. 94:1987;749-761.
4. Thourani V.H., Ronson R.S., Van Wylen D.G., et al. Adenosine- supplemented blood cardioplegia attenuates postischemic dysfunction after severe regional ischemia. Circulation. 100:1999;II376-II383.
5. Apstein C.S. Glucose-insulin-potassium for acute myocardial infarction remarkable results from a new prospective, randomized trial . Circulation. 98:1998;2223-2226.
6. Saupe K.W., Eberli F.R., Ingwall J.S., Apstein C.S. Metabolic support as an adjunct to inotropic support in the hypoperfused heart. J Mol Cell Cardiol. 33:2001;261-269.
7. Cave A.C., Ingwall J.S., Friedrich J., et al. ATP synthesis during low-flow ischemia influence of increased glycolytic substrate . Circulation. 101:2000;2090-2096.
8. Robinson L.A., Braimbridge M.V., Hearse D.J. Creatine phosphate an additive myocardial protective and antiarrhythmic agent in cardioplegia . J Thorac Cardiovasc Surg. 87:1984;190-200.
9. Puskas J.D., Vinten-Johansen J., Muraki S., Guyton R.A. Myocardial protection for off-pump coronary artery bypass surgery. Semin Thorac Cardiovasc Surg. 13:2001;82-88.
10. Selye H., Bajusz E., Grassos S., Mendell P. Simple techniques for the surgical occlusion of coronary vessels in the rat. Angiology. 11:1960;398-407.
11. Ikai I., Okuda M., Doliba N., Chance B. Visibility of ATP and ADP in freeze-trapped tissue from perfused rat liver during normoxia and ischemia using 31P-cryo-NMR. Biochim Biophys Acta. 1074:1991;289-293.
12. Ingwall J.S., Atkinson D.E., Clarke K., Fetters J.K. Energetic correlates of cardiac failure changes in the creatine kinase system in the failing myocardium . Eur Heart J. 11:(Suppl B):1990;108-115.
13. Hassinen I., Ito K., Nioka S., Chance B. Mechanism of fatty acid effect on myocardial oxygen consumption. A phosphorus NMR study. Biochim Biophys Acta. 1019:1990;73-80.
14. 31P-NMR spectroscopy. Mol Cell Biochem. 200:1999;93-102.
15. Yang W.C., Geiger P.J., Besman S.P. Formation of creatine phosphate from creatine and 32P-labelled ATP by isolated rabbit heart mitochondria. Biochem Biophys Res Commun. 76:1977;882-887.
16. Sharov V.G., Afonskaya N.I., Ruda M.Y., et al. Protection of ischemic myocardium by exogenous phosphocreatine (neoton) pharmacokinetics of phosphocreatine, reduction of infarct size, stabilization of sarcolemma of ischemic cardiomyocytes, and antithrombotic action . Biochem Med Metab Biol. 35:1986;101-114.
17. Kryzhanovskii S.A., Kandelaki I.N., Sharov V.G., et al. Effect of exogenous phosphocreatine on the size of experimental myocardial infarction. Kardiologiia. 28:1988;88-91.
18. Saks V.A., Dzhaliashvili I.V., Konorev E.A., Strumia E. Molecular and cellular aspects of the cardioprotective mechanism of phosphocreatine. Biokhimiia. 57:1992;1763-1784.
19. Kapelko V.I., Kupriyanov V.V., Novikova N.A., et al. The cardiac contractile failure induced by chronic creatine and phosphocreatine deficiency. J Mol Cell Cardiol. 20:1988;465-479.
20. Semenovsky M.L., Shumakov V.I., Sharov V.G., et al. Protection of ischemic myocardium by exogenous phosphocreatine. II. Clinical, ultrastructural, and biochemical evaluations. J Thorac Cardiovasc Surg. 94:1987;762-769.
21. Conway M.A., Clark J.F. Creatine and creatine phosphate: Scientific and clinical perspectives. 1996;Academic Press, Harcourt Brace & Company, San Diego, CA.
22. Clark J.F. Creatine and phosphocreatine A review of their use in exercise and sport . J Athletic Training. 32:1997;45-51.