Synthesis and biological activity of novel 5-(ω-aryloxyalkyl)oxazole derivatives as brain-derived neurotrophic factor inducers

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 5, 2003, Pages 565-573

  Maekawa, Tsuyoshi ^a   Sakai, Nozomu ^a   Tawada, Hiroyuki ^a   Murase, Katsuhito ^a   Hazama, Masatoshi ^a   Sugiyama, Yasuo ^a   Momose, Yu ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

5 ( aryloxyalkyl)oxazole; Brain derived neurotrophic factor; Diabetic complication; Diabetic neuropathy; Streptozotocin (STZ) diabetic rat

Indexed keywords

3 [4 CHLOROPHENYL 2 (2 METHYL 1H IMIDAZOL 1 YL) 5 OXAZOLYL] 1 PROPANOL; 4 (4 CHLOROPHENYL) 2 (2 ETHYL 1H IMIDAZOL 1 YL) 5 [3 (2 METHOXYPHENOXY)PROPYL]OXAZOLE; 4 (4 CHLOROPHENYL) 2 (2 METHYL 1H IMIDAZOL 1 YL) 5 [3 (2 METHOXYPHENOXY)PROPYL] 1,3 OXAZOLE; 4 (4 CHLOROPHENYL) 5 [3 (2 HYDROXYPHENOXY)PROPYL] 2 (2 METHYL 1H IMIDAZOL 1 YL)OXAZOLE; 4 (4 CHLOROPHENYL) 5 [3 (2 METHOXYPHENOXY)PROPYL] 2 (2 METHYL 1H IMIDAZOL 1 YL)OXAZOLE; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN PROTEIN; ETHYL 3 [4 (4 CHLOROPHENYL) 2 (2 METHYL 1H IMIDAZOL 1 YL) 5 OXAZOLYL]PROPIONATE; ETHYL 5 [4 (4 CHLOROPHENYL) 2 (2 METHYL 1H IMIDAZOL 1 YL) 5 OXAZOLYL]PENTANOATE; METHYL 3 [4 (4 CHLOROPHENYL) 2 PHENYL 5 OXAZOLYL]PROPIONATE; OXAZOLE DERIVATIVE; STREPTOZOCIN; UNCLASSIFIED DRUG; ALKANE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; MOTOR NERVE CONDUCTION; NEUROBLASTOMA CELL; NONHUMAN; RAT; SCIATIC NERVE; STREPTOZOCIN DIABETES; TAIL FLICK TEST; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; BRAIN LEVEL; BRAIN TUMOR; CELL FRACTIONATION; CHEMISTRY; DIABETIC NEUROPATHY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; METABOLISM; NERVE CONDUCTION; NEUROBLASTOMA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION TIME; SPRAGUE DAWLEY RAT; STIMULATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ALKANES; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; BRAIN CHEMISTRY; BRAIN NEOPLASMS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE, TUMOR; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEURAL CONDUCTION; NEUROBLASTOMA; OXAZOLES; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; STIMULATION, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS;

EID: 0642309875     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.565     Document Type: Article

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