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Volumn 2, Issue 3, 2003, Pages 242-247

Molecular analysis of glioblastoma: Pathway profiling and its implications for patient therapy

Author keywords

Gene expressionprofiling; Glioblastoma; Microarray; Molecular analysis; Phosphatidylinositol 3 kinase (PI3K); PTEN; Signal transduction

Indexed keywords

ANIMAL; BRAIN TUMOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GLIOBLASTOMA; HUMAN; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

EID: 0642306004     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.2.3.369     Document Type: Review
Times cited : (57)

References (41)
  • 1
    • 0035041023 scopus 로고    scopus 로고
    • Brain and other central nervous system tumors: Rates, trends, and epidemiology
    • DOI 10.1097/00001622-200105000-00005
    • Gurney JG, Kadan-Lottick N. Brain and other central nervous system tumors: rates, trends, and epidemiology. Curr Opin Oncol 2001; 13:160-6 (Pubitemid 32433971)
    • (2001) Current Opinion in Oncology , vol.13 , Issue.3 , pp. 160-166
    • Gurney, J.G.1    Kadan-Lottick, N.2
  • 2
    • 0037245929 scopus 로고    scopus 로고
    • Targeted molecular therapy of glioblastoma
    • Mischel PS, Cloughesy, T.F. Targeted molecular therapy of glioblastoma. Brain Pathology 2003; 13:52-61.
    • (2003) Brain Pathology , vol.13 , pp. 52-61
    • Mischel, P.S.1    Cloughesy, T.F.2
  • 3
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: Genetic alterations and mouse models
    • Holland EC. Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2001; 2(:120-9.
    • (2001) Nat Rev Genet , vol.2 , pp. 120-129
    • Holland, E.C.1
  • 4
    • 0032601166 scopus 로고    scopus 로고
    • Primary and secondary glioblastomas: From concept to clinical diagnosis
    • Kleihues P, Ohgaki H. Primary and secondary glioblastomas: from concept to clinical diagnosis. Neuro-oncol 1999; 1:44-51.
    • (1999) Neuro-oncol , vol.1 , pp. 44-51
    • Kleihues, P.1    Ohgaki, H.2
  • 7
    • 0037439688 scopus 로고    scopus 로고
    • Selection pressures of TP53 mutation and microenvironmental location influence epidermal growth factor receptor gene amplification in human glioblastomas
    • Okada Y, Hurwitz EE, Esposito JM, Brower MA, Nutt CL, Louis DN. Selection pressures of TP53 mutation and microenvironmental location influence epidermal growth factor receptor gene amplification in human glioblastomas. Cancer Res 2003; 63:413-6. (Pubitemid 36152501)
    • (2003) Cancer Research , vol.63 , Issue.2 , pp. 413-416
    • Okada, Y.1    Hurwitz, E.E.2    Esposito, J.M.3    Brower, M.A.4    Nutt, C.L.5    Louis, D.N.6
  • 8
    • 0036467568 scopus 로고    scopus 로고
    • Rational therapeutic intervention in cancer: Kinases as drug targets
    • DOI 10.1016/S0959-437X(01)00273-8
    • Sawyers CL. Rational therapeutic intervention in cancer: kinases as drug targets. Curr Opin Genet Dev 2002; 12:111-5. (Pubitemid 34094999)
    • (2002) Current Opinion in Genetics and Development , vol.12 , Issue.1 , pp. 111-115
    • Sawyers, C.L.1
  • 10
    • 0036984461 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor as a targeted therapy for GIST tumors
    • Joensuu H. [Tyrosine kinase inhibitor as a targeted therapy for GIST tumors]. Duodecim 2002; 118:2305-12.
    • (2002) Duodecim , vol.118 , pp. 2305-2312
    • Joensuu, H.1
  • 11
    • 0036463948 scopus 로고    scopus 로고
    • Perspectives on the development of a molecularly targeted agent
    • DOI 10.1016/S1535-6108(02)00025-9
    • Druker BJ. Perspectives on the development of a molecularly targeted agent. Cancer Cell 2002; 1:31-6. (Pubitemid 41039173)
    • (2002) Cancer Cell , vol.1 , Issue.1 , pp. 31-36
    • Druker, B.J.1
  • 12
    • 0036731703 scopus 로고    scopus 로고
    • Imatinib GIST keeps finding new indications: Successful treatment of dermatofibrosarcoma protuberans by targeted inhibition of the platelet-derived growth factor receptor
    • Sawyers CL. Imatinib GIST keeps finding new indications: successful treatment of dermatofibrosarcoma protuberans by targeted inhibition of the platelet- derived growth factor receptor. J Clin Oncol 2002; 20:3568-9. (Pubitemid 34983211)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.17 , pp. 3568-3569
    • Sawyers, C.L.1
  • 13
    • 0037093249 scopus 로고    scopus 로고
    • Influence of unrecognized molecular heterogeneity on randomized clinical trials
    • DOI 10.1200/JCO.2002.06.140
    • Betensky RA, Louis DN, Cairncross JG. Influence of unrecognized molecular heterogeneity on randomized clinical trials. J Clin Oncol 2002; 20:2495-9. (Pubitemid 34525735)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.10 , pp. 2495-2499
    • Betensky, R.A.1    Louis, D.N.2    Cairncross, J.G.3
  • 14
    • 0037407908 scopus 로고    scopus 로고
    • Molecular diagnosis of the hematologic cancers
    • DOI 10.1056/NEJMra020067
    • Staudt LM. Molecular diagnosis of the hematologic cancers. N Engl J Med 2003; 348:1777-85. (Pubitemid 36514709)
    • (2003) New England Journal of Medicine , vol.348 , Issue.18 , pp. 1777-1785
    • Staudt, L.M.1
  • 17
    • 0036132668 scopus 로고    scopus 로고
    • Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets
    • Fuller GN, Hess KR, Rhee CH, Yung WK, Sawaya RA, Bruner JM, et al. Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets. Brain Pathol 2002; 12:108-16. (Pubitemid 33131367)
    • (2002) Brain Pathology , vol.12 , Issue.1 , pp. 108-116
    • Fuller, G.N.1    Hess, K.R.2    Rhee, C.H.3    Yung, W.K.A.4    Sawaya, R.A.5    Bruner, J.M.6    Zhang, W.7
  • 20
    • 0345240919 scopus 로고    scopus 로고
    • Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: A revelation by parallel gene expression profiling
    • Fuller GN, Rhee CH, Hess KR, Caskey LS, Wang R, Bruner JM, et al. Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling. Cancer Res 1999; 59:4228-32. (Pubitemid 29418733)
    • (1999) Cancer Research , vol.59 , Issue.17 , pp. 4228-4232
    • Fuller, G.N.1    Rhee, C.H.2    Hess, K.R.3    Caskey, L.S.4    Wang, R.5    Bruner, J.M.6    Yung, W.K.A.7    Zhang, W.8
  • 21
    • 0034812859 scopus 로고    scopus 로고
    • Towards a novel classification of human malignancies based on gene expression patterns
    • DOI 10.1002/path.889
    • Alizadeh AA, Ross DT, Perou CM, van de Rijn M. Towards a novel classification of human malignancies based on gene expression patterns. J Pathol 2001;195:41-52. (Pubitemid 32899044)
    • (2001) Journal of Pathology , vol.195 , Issue.1 , pp. 41-52
    • Alizadeh, A.A.1    Ross, D.T.2    Perou, C.M.3    Van De, R.M.4
  • 22
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999; 286:531-7.
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3    Huard, C.4    Gaasenbeek, M.5    Mesirov, J.P.6
  • 28
    • 0030017885 scopus 로고    scopus 로고
    • Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
    • discussion 23-4
    • Watanabe K, Tachibana O, Sata K, Yonekawa Y, Kleihues P, Ohgaki H. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996; 6:217-23; discussion 23-4.
    • (1996) Brain Pathol , vol.6 , pp. 217-223
    • Watanabe, K.1    Tachibana, O.2    Sata, K.3    Yonekawa, Y.4    Kleihues, P.5    Ohgaki, H.6
  • 31
    • 0034764605 scopus 로고    scopus 로고
    • PI 3-kinase, mTOR, protein synthesis and cancer
    • DOI 10.1016/S1471-4914(01)02161-X, PII S147149140102161X
    • Vogt PK. PI 3-kinase, mTOR, protein synthesis and cancer. Trends Mol Med 2001; 7:482-4. (Pubitemid 33021671)
    • (2001) Trends in Molecular Medicine , vol.7 , Issue.11 , pp. 482-484
    • Vogt, P.K.1
  • 32
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489-501. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 33
    • 0030771026 scopus 로고    scopus 로고
    • Signal transduction pathways and their relevance in human astrocytomas
    • DOI 10.1023/A:1005800114912
    • Feldkamp MM, Lau, N., Guha, A. Signal transduction pathways and their relevance in human astrocytomas. Journal of Neurooncology 1997; 35:223-248. (Pubitemid 27511128)
    • (1997) Journal of Neuro-Oncology , vol.35 , Issue.3 , pp. 223-248
    • Feldkamp, M.M.1    Lau, N.2    Guha, A.3
  • 34
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    • DOI 10.1038/75596
    • Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 2000; 25:55-7. (Pubitemid 30257036)
    • (2000) Nature Genetics , vol.25 , Issue.1 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5    Fuller, G.N.6
  • 35
    • 0036791177 scopus 로고    scopus 로고
    • Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt
    • Uhrbom L, Dai C, Celestino JC, Rosenblum MK, Fuller GN, Holland EC. Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. Cancer Res 2002; 62:5551-8.
    • (2002) Cancer Res , vol.62 , pp. 5551-5558
    • Uhrbom, L.1    Dai, C.2    Celestino, J.C.3    Rosenblum, M.K.4    Fuller, G.N.5    Holland, E.C.6
  • 36
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002; 298:1911-2.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 38
    • 0034163550 scopus 로고    scopus 로고
    • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
    • Frederick L, Wang XY, Eley G, James CD. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res 2000; 60:1383-7. (Pubitemid 30152011)
    • (2000) Cancer Research , vol.60 , Issue.5 , pp. 1383-1387
    • Frederick, L.1    Wang, X.-Y.2    Eley, G.3    James, C.D.4
  • 39
    • 3142737393 scopus 로고    scopus 로고
    • Genetic and signaling pathway alterations in glioblastoma: Relevance to novel targeted therapies
    • Rao RD, Uhm JH, Krishnan S, James CD. Genetic and signaling pathway alterations in glioblastoma: relevance to novel targeted therapies. Front Biosci 2003; 8:E270-80.
    • (2003) Front Biosci , vol.8
    • Rao, R.D.1    Uhm, J.H.2    Krishnan, S.3    James, C.D.4
  • 40
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signaling
    • Blume-Jensen P, Hunter, T. Oncogenic kinase signaling. Nature 2001;411(6835):355-365.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 41
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the Phosphatidyl 3'-Kinase Signaling Pathway in Glioblastoma Patients in Vivo
    • In Press
    • Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, et al. Analysis of the Phosphatidyl 3'-Kinase Signaling Pathway in Glioblastoma Patients in Vivo. Cancer Research 2003; 63:In Press.
    • (2003) Cancer Research , vol.63
    • Choe, G.1    Horvath, S.2    Cloughesy, T.F.3    Crosby, K.4    Seligson, D.5    Palotie, A.6


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