High sensitivity detection of molecular recognition using magnetically labelled biomolecules and magnetoresistive sensors

Biosensors and Bioelectronics

Volumn 18, Issue 4, 2003, Pages 483-488

  Graham, D L ^a   Ferreira, H A ^a,b   Freitas, P P ^a,b   Cabral, J M S ^b  

^a INESC   (Portugal)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

Author keywords

Biochips; Biosensors; Magnetoresistive sensors; Molecular recognition

Indexed keywords

ELECTRIC CURRENTS; MAGNETORESISTANCE; MOLECULAR DYNAMICS; SIGNAL PROCESSING; SURFACES; VITAMINS;

BIOCHIPS; BIOTINYLATED SENSORS; MAGNETIC MICROSPHERES; MAGNETORESISTIVE SENSORS; MOLECULAR RECOGNITION; SPIN VALVE SENSORS;

BIOSENSORS;

BIOTIN; MICROSPHERE; STREPTAVIDIN;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; BIOSENSOR; BIOTINYLATION; MAGNETIC FIELD; MAGNETISM; MOLECULAR RECOGNITION; NANOTECHNOLOGY; SIGNAL NOISE RATIO; SPIN LABELING; STAINING; TEMPERATURE; TRANSDUCER; CHEMISTRY; EQUIPMENT DESIGN; EVALUATION; GENETIC PROCEDURES; INSTRUMENTATION; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

ANTIGEN-ANTIBODY COMPLEX; BIOSENSING TECHNIQUES; BIOTIN; EQUIPMENT DESIGN; MAGNETICS; MICROCHEMISTRY; MICROSPHERES; NANOTECHNOLOGY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPIN LABELS; STAINING AND LABELING; STREPTAVIDIN; TRANSDUCERS;

EID: 0642279487     PISSN: 09565663     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0956-5663(02)00205-1     Document Type: Article

References (16)

1. Allen, S., Davies, M.C., Roberts, C.J., Tendler, S.J.B., Williams, P.M., 1997. Atomic force microscopy in analytical biotechnology. Tibtechnology 15, 101-105.
2. Baibich, M.N., Broto, J.M., Pert, A., Van Dau, F.N., Petroff, F., 1988. Giant magnetoresistance of (001)Fe/(001)Cr magnetic superlattices. Phys. Rev. Lett. 61, 2472-2475.
3. Baselt, D.R., Lee, G.U., Natesan, M., Metzger, S.W., Sheehan, P.E., Colton, R.J., 1998. A biosensor based on magnetoresistance technology. Biosens. Bioelectron. 13, 731-739.
4. Edelstein, R.L., Tamanaha, C.R., Sheehan, P.E., Miller, M.M., Baselt, D.R., Whitman, L.J., Colton, R.J., 2000. The BARC biosensor applied to the detection of biological warfare agents. Biosens. Bioelectron. 14, 805-813.
5. Freitas, P.P., Silva, F., Oliveira, N.J., Melo, L.V., Costa, L., Almeida, N., 2000. Spin valve sensors. Sens. Actual. A 81, 2-8.
6. Graham, D.L., Ferreira, H.A., Bernardo, J., Freitas, P.P., Cabral, J.M.S., 2002. Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: biotechnological applications. J. Appl. Phys. 91 (10), 7786-7788.
7. Lu, H.P., Xie, S., 1997. Single molecule spectral fluctuations at room temperature. Nature 385, 143-146.
8. Lu, H.P., Xun, L., Xie, X.S., 1998. Single molecule enzymatic dynamics. Science 282, 1877-1882.
9. Michaelis, J., Hettich, C., Mlynek, J., Sandoghar, V.V., 2000. Optical microscopy using single molecule light source. Nature 405, 325-328.
10. Miller, M.M., Sheehan, P.E., Edelstein, R.L., Tamanaha, C.R., Zhong, L., Bounnak, L.J., Whitman, L.J., Colton, R.J., 2001. A DNA array sensor utilizing magnetic microbeads and magnetoelectronic detection. J. Magn. Mag. Mater. 225, 138-144.
11. Nie, S., Chiu, D.T., Zare, R.N., 1994. Probing individual molecules with confocal fluorescence microscopy. Science 266, 1018-1021.
12. Osbourne, M.A., Scott Furey, W., Klenerman, D., Balasubramanian, S., 2000. Single molecule analysis of DNA immobilised on microspheres. Anal. Chem. 72, 3678-3681.
13. Pérez-Luna, V.H., O'Brien, M.J., Opperman, K.A., Hampton, P.D., López, G.P., Klumb, L.A., Stayton, P.S., 1999. Molecular recognition between genetically engineered streptavidin and surface-bound biotin. J. Am. Chem. Soc. 121, 6469-6478.
14. Radmacher, M., Fritz, M., Hansma, H.G., Hansma, P.K., 1994. Direct observation of enzyme activity with the atomic force microscope. Science 265, 1577-1579.
15. Tondra, M., Porter, M., Lipert, R.L., 2000. Model for the detection of immobilised Superparamagnetic nanosphere assay labels using giant magnetoresistive sensors. J. Vac. Sci. A 18 (4), 1125-1129.
16. Van Craenenbroeck, E., Engelborghs, Y., 2000. Fluorescence correlation spectroscopy: molecular recognition at the single molecule level. J. Mol. Recognit. 13 (2), 93-100.