Antipsychotics regulate cyclic AMP-dependent protein kinase and phosphorylated cyclic AMP response element-binding protein in striatal and cortical brain regions in mice

Neuroscience Letters

Volumn 357, Issue 1, 2004, Pages 53-57

  Turalba, Angela V ^a   Leite Morris, Kimberly A ^b,c   Kaplan, Gary B ^b,c  

^a BROWN UNIVERSITY   (United States)

^b PROVIDENCE VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

Antipsychotic agents; Cyclic AMP; Mouse; Phosphorylation; Prefrontal cortex; Striatum; Transcription

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; ENZYME REGULATION; MALE; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0442323511     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2003.11.059     Document Type: Article

References (18)

1. Adams M.R., Brandon E.P., Chartoff E.H., Idzerda R.L., Dorsa D.M., McKnight G.S. Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice. Proc. Natl. Acad. Sci. USA. 94:1997;12157-12161.
2. Adams A.C., Keefe K.A. Examination of the involvement of protein kinase A in D2 dopamine receptor antagonist-induced immediate early gene expression. J. Neurochem. 77:2001;326-335.
3. Bymaster F.P., Calligaro D.O., Falcone J.F., Marsh R.D., Moore N.A., Tye N.C., Seeman P., Wong D.T. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 14:1996;87-96.
4. Creese I., Burt D.R., Snyder S.H. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science. 192:1976;481-483.
5. 3H]cyclic AMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. J. Pharmacol. Exp. Ther. 301:2002;197-209.
6. Egan C.T., Herrick-Davis K., Teitler M. Creation of a constitutively activated state of the 5-hydroxytryptamine 2A receptor by site-directed mutagenesis: inverse agonist activity of antipsychotic drugs. J. Pharmacol. Exp. Ther. 286:1998;85-90.
7. Franklin K.B.J., Paxinos G. The Mouse Brain in Stereotaxic Coordinates. 1997;Academic Press, San Diego.
8. Hirst W.D., Price G.W., Rattray M., Wilkin G.P. Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. Br. J. Pharmacol. 120:1997;509-515.
9. Kaneko M., Sato K., Horikoshi R., Yaginuma M., Yaginuma N., Shiragata M., Kumashiro H. Effect of haloperidol on cyclic AMP and inositol triphosphate in rat striatum in vivo. Prostaglandins Leukot. Essent. Fatty Acids. 46:1992;53-57.
10. Kaplan G.B., Leite-Morris K.A., Joshi M., Shoeb M., Carey R. Baclofen inhibits opiate-induced conditioned place preference and associated induction of Fos in cortical and limbic regions. Brain Res. 987:2003;122-125.
11. Kaplan G.B., Leite-Morris K.A., Keith D.J. Differential effects of chronic treatment with typical and atypical antipsychotic drugs on G proteins and adenylyl cyclase. Neurosci. Lett. 273:1999;147-150.
12. Konradi C., Kobierski L.A., Nguyen T.V., Heckers S., Hyman S.E. The cyclic AMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum, Proc. Natl. Acad. Sci. USA. 90:1993;7005-7009.
13. Leite-Morris K.A., Kaplan G.B., Smith J.G., Sears M.T. Regulation of G proteins and adenylyl cyclase in brain regions of caffeine-tolerant and -dependent mice. Brain Res. 804:1998;52-62.
14. Moore H., Todd C.L., Grace A.A. Striatal extracellular dopamine levels in rats with haloperidol-induced depolarization block of substantia nigra dopamine neurons. J. Neurosci. 18:1998;5068-5077.
15. Wadenberg M.L., Soliman A., VanderSpeck S.C., Kapur S. Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effect. Neuropsychopharmacology. 25:2001;633-641.
16. Wilson J., Lin H., Fu D., Javitch J.A., Strange P.G. Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation. J. Neurochem. 77:2001;493-504.
17. Yan Z., Feng J., Fienberg A.A., Greengard P. D(2) dopamine receptors induce mitogen-activated protein kinase and cyclic AMP response element-binding protein phosphorylation in neurons. Proc. Natl. Acad. Sci. USA. 96:1999;11607-11612.
18. Zhang W., Bymaster F.P. The in vivo effects of olanzapine and other antipsychotic agents on receptor occupancy and antagonism of dopamine D1, D2, D3, 5HT2A and muscarinic receptors. Psychopharmacology (Berlin). 141:1999;267-278.