Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum

BMC Molecular Biology

Volumn 3, Issue , 2002, Pages

  Agaphonov, Michael O ^a   Romanova, Nina V ^a   Trushkina, Polina M ^a   Smirnov, Vladimir N ^a   Ter Avanesyan, Michael D ^a  

^a INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT PLASMINOGEN ACTIVATOR; UROKINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE DELETION; GENETIC ANALYSIS; GOLGI COMPLEX; HANSENULA POLYMORPHA; HUMAN; MOLECULAR WEIGHT; PLASMINOGEN ACTIVATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN SECRETION;

PICHIA; PICHIA ANGUSTA;

EID: 0442310898     PISSN: 14712199     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2199-3-15     Document Type: Article

References (27)

1. Finger A, Knop M, Wolf DH: Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast. Eur J Biochem 1993, 218:565-574
2. Kang HA, Lee KN, Yu MH: Folding and stability of the Z and S(iiyama) genetic variants of human alpha1-antitrypsin. J Biol Chem 1997, 272:510-516
3. Hiller MM, Finger A, Schweiger M, Wolf DH: ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway. Science 1996, 273:1725-1728
4. Werner ED, Brodsky JL, McCracken AA: Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate. Proc Natl Acad Sci U S A 1996, 93:13797-13801
5. Hong E, Davidson AR, Kaiser CA: A pathway for targeting soluble misfolded proteins to the yeast vacuole. J Cell Biol 1996, 135:623-633
6. Holkeri H, Makarow M: Different degradation pathways for heterologous glycoproteins in yeast. FEBS Lett 1998, 429:162-166
7. Parodi AJ: Reglucosylation of glycoproteins and quality control of glycoprotein folding in the endoplasmic reticulum of yeast cells. Biochim Biophys Acta 1999, 1426:287-295
8. 2+ ATPase family. Cell 1989, 58:133-145
9. Packeiser AN, Urakov VN, Polyakova YA, Shimanova NI, Shcherbukhin VD, Smirnov VN, Ter-Avanesyan MD: A novel vacuolar protein encoded by SSU21/MCD4 is involved in cell wall integrity in yeast. Yeast 1999, 15:1485-1501
10. Agaphonov MO, Packeiser AN, Chechenova MB, Choi ES, Ter-Avanesyan MD: Mutation of the homologue of GDP-mannose pyrophosphorylase alters cell wall structure, protein glycosylation and secretion in Hansenula polymorpha. Yeast 2001, 18:391-402
11. 2+ required for glycosylation, sorting, and endoplasmic reticulum-associated protein degradation. Mol Biol Cell 1998, 9:1149-1162
12. Lijnen HR, Collen D: Strategies for the improvement of thrombolytic agents. Thromb Haemost 1991, 66:88-110
13. Melnick LM, Turner BG, Puma P, Price-Tillotson B, Salvato KA, Dumais DR, Moir DT, Broeze RJ, Avgerinos GC: Characterization of a nonglycosylated single chain urinary plasminogen activator secreted from yeast. J Biol Chem 1990, 265:801-807
14. Wang P, Zhang J, Sun Z, Chen Y, Gurewich V, Liu JN: Catalytic and fibrinolytic properties of recombinant urokinase plasminogen activator from E. coli, mammalian, and yeast cell. Thromb Res 2000, 100:461-467
15. Knop M, Hauser N, Wolf DH: N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast. Yeast 1996, 12:1229-1238
16. Agaphonov MO, Poznyakovski AI, Bogdanova AI, Ter-Avanesyan MD: Isolation and characterization of the LEU2 gene of Hansenula polymorpha. Yeast 1994, 10:509-513
17. Sohn JS, Choi ES, Kim CH, Agaphonov MO, Ter-Avanesyan MD, Rhee JS, Rhee SK: A novel autonomously replicating sequence (ARS) for multiple integration in the yeast Hansenula polymorpha DL-1. J Bacteriol 1996, 178:4420-4428
18. Agaphonov MO, Beburov MY, Ter-Avanesyan MD, Smirnov VN: A disruption-replacement approach for the targeted integration of foreign genes in Hansenula polymorpha. Yeast 1995, 11:1241-1247
19. Agaphonov MO, Trushkina PM, Sohn J-H, Choi E-S, Rhee S-K, Ter-Avanesyan MD: Vectors for rapid selection of integrants with different plasmid copy numbers in the yeast Hansenula polymorpha DL1. Yeast 1999, 15:541-551
20. Yoshida S, Ohya Y, Hirose R, Nakano A, Anraku Y: STT10, a novel class-D VPS yeast gene required for osmotic integrity related to the PKC1/STT1 protein kinase pathway. Gene 1995, 160:117-122
21. Cesareni G, Murray AH: Plasmid vectors carrying the replication origin of filamentous single-stranded phages. In: Genetic Engineering: Principles and Methods (Edited by: Setlow JK) New York, Plenum Press 1987, 135-154
22. Astrup T, Muellerts S: Fibrin plate method for estimating fibrinolytic activity. Arch Biochem Biophys 1952, 40:346-351
23. Kratasyuk GA, Jakubov LZ, Sinitsyn VV, Domogatsky SP, Rohklin OV, Koltsova SV, Bynyaeva NA, Fedorova ZD, Samsonov GV: Monoclonal antibodies for single-step isolation of high purity urokinase. Biopolim Kletka 1989, 5:95-101In Russian
24. Herbert D, Phipps PJ, Strange RE: Chemical analysis of microbial cells. Methods Microbiol 1971, 5:244-249
25. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254
26. Bogdanova AI, Agaphonov MO, Ter-Avanesyan MD: Plasmid reorganization during integrative transformation in Hansenula polymorpha. Yeast 1995, 11:343-353
27. Inoue H, Nojima H, Okayama H: High efficiency transformation of Escherichia coli with plasmids. Gene 1990, 96:23-28