Dopaminergic neurons associate with blood vessels in neural transplants

Experimental Neurology

Volumn 184, Issue 2, 2003, Pages 785-793

  Casper, Diana ^a,c   Finkelstein, Eric ^a   Goldstein, Ira M ^a   Palencia, David ^a   Yunger, Yaacov ^b   Pidel, Ann ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b YESHIVA UNIVERSITY   (United States)

^c MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Dopaminergic neurons; Neurodegeneration; Parkinson's disease; Transplantation; Vascularization

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; BRAIN TISSUE; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DENSITY GRADIENT CENTRIFUGATION; DOPAMINERGIC NERVE CELL; EMBRYO; FEMALE; HOST; MALE; MESENCEPHALON; NEIGHBOR JOINING METHOD; NERVE FUNCTION; NERVE GRAFT; NERVE TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL AUTOCORRELATION ANALYSIS; TOPOGRAPHY; VASCULARIZATION;

EID: 0442310711     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4886(03)00336-4     Document Type: Article

References (46)

1. Abrous N., Guy J., Vigny A., Calas A., Le Moal M., Herman J.F. Development of intracerebral dopaminergic grafts: a combined immunohistochemical and autoradiographic study of its time course and environmental influences. J. Comp. Neurol. 273:1988;26-41.
2. Akalan N., Grady M.S. Angiogenesis and the blood-brain barrier in intracerebral solid cell suspension grafts. Surg. Neurol. 42:1994;517-522.
3. Apostolides C., Sandord E., Hong M., Mendez I. Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells. Neuroscience. 83:1998;363-372.
4. Baker-Cairns B.J., Sloan D.J., Broadwell R.D., Puklavel M., Charlton H.M. Contributions of donor and host blood vessels in CNS allografts. Exp. Neurol. 142:1996;36-46.
5. Bär T. The vascular system of the cerebral cortex. Adv. Anat. Embryol. Cell Biol. 59:1980;1-62.
6. Barker R.A., Dunnett S.B., Faissner A., Fawcett J.W. The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum. Exp. Neurol. 141:1996;79-93.
7. Baumgartner I., Pieczek A., Manor O., Blair R., Kearney M., Walsh K., Isner J.M. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation. 97:1998;1114-1123.
8. Blum M., Casper D., Shannon C. Growth factors involved in the development, maturation and neuroplasticity of midbrain dopamine neurons. Fuxe K., Agnati L.F., Ottoson D. Trophic Regulation of the Basal Ganglia. Focus on Dopamine Neurons. 1994;203-216 Pergamon, New York.
9. Broadwell R.D., Charlton H.M., Balin B.J., Salcman M. Angioarchitecture of the CNS, pituitary gland, and intracerebral grafts revealed with peroxidase cytochemistry. J. Comp. Neurol. 260:1987;47-64.
10. Brundin P., Barbin G., Strecker R.E., Isacson O., Prochiantz A., Björklund A. Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro. Dev. Brain Res. 39:1988;233-243.
11. Casper D., Engstrom S.J., Mirchandani G.R., Pidel A., Palencia D., Cho P.H., Brownlee M., Edelstein D., Federoff H.J., Sonstein W.J. Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer. Cell Transplant. 11:2002;331-349.
12. Choi H.K., Won L., Heller A. Dopaminergic neurons grown in three-dimensional reaggregate culture for periods of up to one year. J. Neurosci. Methods. 46:1993;233-244.
13. Emgård M., Karlsson J., Hansson O., Brundin P. Patterns of cell death and dopaminergic neuron survival in intrastriatal nigral grafts. Exp. Neurol. 160:1999;279-288.
14. Fawcett J.W., Barker R.A., Dunnett S.B. Dopaminergic neuronal survival and the effects of bFGF in explant, three dimensional and monolayer cultures of embryonic rat ventral mesencephalon. Exp. Brain Res. 106:1995;275-282.
15. Geny C., Naimi-Sadaoui S., Jeny R., Belkadi A.M., Juliano S.L., Peshanski M. Long-term delayed vascularization of human neural transplants to the rat brain. J. Neurosci. 14:1994;7553-7562.
16. Heller A., Kontur P., Hoffmann P., Heller B. Quantitation of neurochemically identified neurons in reaggregate tissue cultures. J. Neurosci. Methods. 25:1988;83-90.
17. Isner J.M., Walsh K., Symes J., Pieczek A., Takeshita S., Lowry J., Rossow S., Rosenfield K., Weir L., Brogi E., Schainfeld R. Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease. Circulation. 91:1995;2687-2692.
18. Krum J.M., Rosenstein J.M. Patterns of angiogenesis in neural transplant models: II. Fetal neocortical transplants. J. Comp. Neurol. 271:1988;331-345.
19. Krum J.M., Rosenstein J.M. The fine structure of vascular-astroglial relations in transplanted fetal neocortex. Exp. Neurol. 103:1989;203-212.
20. Lawrence J.M., Huang S.K., Raisman G. Vascular and astrocytic reactions during establishment of hippocampal transplants in adult host brain. Neuroscience. 12:1984;745-760.
21. Leigh K., Elisevich K., Rogers K.A. Vascularization and microvascular permeability in solid versus cell-suspension embryonic neural grafts. J. Neurosurg. 81:1994;272-283.
22. Ling Z.D., Collier T.J., Sortwell C.E., Lipton J.W., Vu T.Q., Robie H.C., Carvey P.M. Striatal trophic activity is reduced in the aged rat brain. Brain Res. 856:2000;301-309.
23. Mahalik T., Clayton G. Specific outgrowth from neurons of ventral mesencephalic grafts to the catecholamine-depleted striatum of adult hosts. Exp. Neurol. 113:1991;18-27.
24. Mavelli I., Rigo A., Federico R., Ciriolo M.R., Rotilio G. Superoxide dismutase glutathione peroxidase and catalase in developing rat brain. Biochem. J. 204:1982;535-540.
25. Mayer E., Fawcett J.W., Dunnett S.B. Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons - II. Effects on nigral transplants in vivo. Neuroscience. 56:1993;389-398.
26. Nikkhah G., Cunningham M.G., Jödicke A., Knappe U., Björklund A. Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model. Brain Res. 633:1994;133-143.
27. Plate K.H. Mechanisms of angiogenesis in the brain. J. Neuropathol. Exp. Neurol. 58:1999;313-320.
28. Proescholdt M.A., Heiss J.D., Walbridge S., Mulhauser J., Capogrossi M.C., Oldfield E.H., Merrill M.J. Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain. J. Neuropathol. Exp. Neurol. 58:1999;613-627.
29. Robertson P.L., Du Bois M., Bowman P.D., Goldstein G.W. Angiogenesis in the developing rat brain: an in vivo and in vitro study. Dev. Brain Res. 23:1985;219-223.
30. Rosenblad C., Martinez-Serrano A., Björklund A. Glial cell line-derived neurotrophic factor increases survival, growth, and function of intrastriatal fetal nigral dopaminergic grafts. Neuroscience. 75:1996;979-985.
31. Rosenstein J.M., Brightman M.W. Alterations of the blood-brain barrier after transplantation of autonomic ganglia into the mammalian central nervous system. J. Comp. Neurol. 250:1986;339-351.
32. Sauer H., Fischer W., Nikkhah G., Wiegand S.J., Brundin P., Lindsay R.M., Björklund A. Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts. Brain Res. 626:1993;37-44.
33. Schweiki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 359:1992;843-845.
34. Scott D.E. Fetal hypothalamic transplants: neuronal and neurovascular interrelationships. Neurosci. Lett. 51:1984;93-98.
35. Sinclair S.R., Svendsen C.N., Torres E.M., Martin D., Fawcett J.W., Dunnett S.B. GDNF enhances dopaminergic cell survival and fibre outgrowth in embryonic nigral grafts. NeuroReport. 7:1996;2547-2552.
36. Sortwell C.E., Pitzer M.R., Collier T.J. Time course of apoptotic cell death within mesencephalic cell suspension grafts: implications for improving grafted dopamine neuron survival. Exp. Neurol. 165:2000;268-277.
37. Steinbusch H.W.M., Vermuelen R.J., Tonnaer A.D.M. Basic fibroblast growth factor enhances the survival and sprouting of fetal dopaminergic cells implanted in the denervated rat caudate-putamen: preliminary observations. Prog. Brain Res. 82:1990;81-86.
38. Stenevi U., Björklund A., Svendgaard N.-Å. Transplantation of central and peripheral monoamine neurons to the adult rat brain: techniques and conditions for survival. Brain Res. 114:1976;1-20.
39. Takayama J., Ray J., Raymon H.K., Baird A., Hogg J., Fisher L.J., Gage F.H. Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nat. Med. 1:1995;53-58.
40. Tennyson V.M., Mytilineou C., Barrett R.E. Fluorescence and electron microscopic studies of the early development of the substantia nigra and area ventralis tegmenti in the fetal rabbit. J. Comp. Neurol. 149:1973;233-258.
41. Yurek D.M. Glial cell-line derived neurotrophic factor improves the survival of dopaminergic neurons in transplants of fetal ventral mesencephalic tissue. Exp. Neurol. 153:1998;195-202.
42. Yurek D.M., Fletcher-Turner A. GDNF partially protects grafted fetal dopaminergic neurons against 6-hydroxydopamine neurotoxicity. Brain Res. 845:1999;21-27.
43. Yurek D.M., Kipkens S.B., Wiegand S.J., Altar C.A. Optimal effectiveness of BDNF for fetal nigral transplants coincides with the ontogenic appearance of BDNF in the striatum. J. Neurosci. 18:1998;6040-6047.
44. Zagzag D. Angiogenic growth factors in neural embryogenesis and neoplasia. Am. J. Pathol. 146:1995;293-309.
45. Zawada W.M., Zastrow D.J., Clarkson E.D., Adams F.S., Bell K.P., Freed C.R. Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Res. 786:1998;96-103.
46. Zhou C.-F., Lindsay R.M., Lawrence J.M., Raisman G. Extent of survival and vascularization of adult superior cervical sympathetic or nodose ganglia transplanted into the septal nuclei or choroid fissure of adult rats. Neuroscience. 17:1986;803-813.