Antitumoral properties of two new vanadyl(IV) complexes in osteoblasts in culture: Role of apoptosis and oxidative stress

Cancer Chemotherapy and Pharmacology

Volumn 53, Issue 2, 2004, Pages 163-172

  Molinuevo, María S ^a   Barrio, Daniel A ^a   Cortizo, Ana M ^a   Etcheverry, Susana B ^a  

^a FACULTAD DE CIENCIAS EXACTAS   (Argentina)

Author keywords

Anticancer activity; Apoptosis; Osteoblasts; Oxidative stress; Vanadium complexes

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CRYSTAL VIOLET; GLUCOSE; LIGAND; LIPID; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; NAPROXEN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; VANADYL DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ASSAY; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CELL TRANSFORMATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ACTIVITY; EVALUATION; INHIBITION KINETICS; LIPID PEROXIDATION; MEASUREMENT; MICROSCOPY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOSARCOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRUCTURE ANALYSIS; TUMOR CELL; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; GLUCOSE; LIPID PEROXIDATION; MICE; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; MITOTIC INDEX; NAPROXEN; OSTEOBLASTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; VANADIUM COMPOUNDS;

EID: 0442282174     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-003-0708-7     Document Type: Article

References (42)

1. Aubrecht J, Narla RK, Ghosh P, Stanek J, Uckun FM (1999) Molecular genotoxicity profiles of apoptosis-inducing vanadocene complexes. Toxicol Appl Pharmacol 154:228
2. Barrio DA, Braziunas MD, Etcheverry SB, Cortizo AM (1997) Maltol complexes of vanadium (IV) and (V) regulate in vitro alkaline phosphatase activity and osteoblast-like cell growth. J Trace Elem Med Biol 11:110
3. Bishayee A, Roy S, Chatterjee M (1999) Characterization of selective induction and alteration of xenobiotic biotransforming enzymes by vanadium during diethylnitrosamine-induced chemical rat liver carcinogenesis. Oncol Res 11:41
4. Blázquez C, Galve-Roperh I, Guzmán M (2000) De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase. FASEB J 14:2315
5. Bradford M (1976) Rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248
6. Cortizo AM, Etcheverry SB (1995) Vanadium derivatives act as growth factor mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells. Mol Cell Biochem 145:97
7. Cortizo AM, Bruzzone L, Molinuevo S, Etcheverry SB (2000) A possible role of oxidative stress in the vanadium-induced cytotoxicity in the MC3T3E1 osteoblast and UMR106 osteosarcoma cell lines. Toxicology 147:89
8. Cortizo MS, Alessandrini JL, Etcheverry SB, Cortizo AM (2001) A vanadium/aspirin complex controlled release using a poly(beta-propiolactone) film. Effects on osteosarcoma cells. J Biomater Sci Polym Ed 12:945
9. Djordjevic C (1995) Antitumor activity of vanadium compounds. In: Sigel H, Sigel A (eds) Metal ions in biological systems, vol 31. Marcel Dekker, New York, p 595
10. D'Onofrio F, Le MQ, Chiasson JL, Srivastava AK (1994) Activation of mitogen activated protein (MAP) kinases by vanadate is independent of insulin receptor autophosphorylation. FEBS Lett 340:269
11. El-Naggar MM, El-Waseef AM, El-Halafawy KM, El-Sayed IH (1998) Antitumor activities of vanadium(IV), manganese(IV), iron(III), cobalt(II) and copper(II) complexes of 2-methylaminopyridine. Cancer Lett 133:71
12. Etcheverry SB, Cortizo AM (1998) Bioactivity of vanadium compounds in cells in culture. In: Nriagu JO (ed) Vanadium in the environment, part one. John Wiley and Sons, New York, p 359
13. Etcheverry SB, Crans DC, Keramidas AD, Cortizo AM (1997) Insulin-mimetic action of vanadium compounds on osteoblast-like cells in culture. Arch Biochem Biophys 338:7
14. Etcheverry SB, Williams PAM, Baran EJ (1997) Synthesis and characterization of vanadyl (IV) complexes with saccharides. Carbohydr Res 302:131
15. 2+/aspirin complex. J Inorg Biochem 80:169
16. Etcheverry SB, Barrio DA, Cortizo AM, Williams PAM (2002) Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (ibuprofen, naproxen and tolmetin). Bioactivity on osteoblast-like cells in culture. J Inorg Biochem 88:94
17. Etcheverry SB, Williams PAM, Sálice VC, Barrio DA, Ferrer EG, Cortizo AM (2002) Biochemical properties and mechanism of action of a vanadyl(IV)-aspirin complex on bone cell lines in culture. Biometals 15:37
18. Etcheverry SB, Barrio DA, Molinuevo MS, Cortizo AM (2002) Two new vanadyl(IV) complexes with potential antineoplastic effect on osteoblasts in culture. In: Khassanova L, Collery Ph, Maymard I, Khassanova Z, Ètienne JC (eds) Metal ions in biology and medicine, vol 7. John Libbey Eurotext, Paris, p 629
19. Evangelou A, Karkabounas S, Kalpouzos G, Malamas M, Liasko R, Stefanou D, Vlahos AT, Kabanos TA (1997) Comparison of the therapeutic effects of two vanadium complexes administered at low dose on benzo[a]pyrene-induced malignant tumors in rats. Cancer Lett 119:221
20. Granchi D, Cenni E, Ciapetti G, Savarino L, Stea S, Gamberini S, Gori A, Pizzoferrato A (1998) Cell death induced by metal ions: necrosis or apoptosis?. J Mater Sci 9:31
21. Gresser MJ, Tracey AS (1990) Vanadate as phosphate analogs in biochemistry. In: Chasteen ND (ed) Vanadium in biological systems. Kluwer Academic, Dordrecht, p 63
22. Huang C, Zhang Z, Ding M, Li J, Ye J, Leonard SS, Shen HM, Butterworth L, Lu Y, Costa M, Rojanasakul Y, Castranova V, Vallyathan V, Shi X (2000) Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis. J Biol Chem 275:32516
23. Jackson JK, Min W, Cruz TF, Cindric S, Arsenault L, Von Hoff DD, Degan D, Hunter WL, Burt HM (1997) A polymer-based drug delivery system for the antineoplastic agent bis(maltolato)oxovanadium in mice. Br J Cancer 75:1014
24. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84:1415
25. Krejsa CM, Nadler SG, Kavanagh TJ, Ledbetter JA, Schieven GL (1997) Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. J Biol Chem 272:11541
26. Liasko R, Kabanos TA, Karkabounas S, Malamas M, Tasiopoulos AJ, Stefanou D, Collery P, Evangelou A (1998) Beneficial effects of a vanadium complex with cysteine, administered at low doses on benzo(alpha)pyrene-induced leiomyosarcomas in Wistar rats. Anticancer Res 18:3609
27. McCarthy AD, Etcheverry SB, Cortizo AM (1999) Advanced glycation endproduct-specific receptors in rat and mouse osteoblast-like cells: regulation with stages of differentiation. Acta Diabetol 36:45
28. Narla RK, Dong Y, Klis D, Uckun FM (2001) Bis(4,7-dimethyl-1,10- phenanthroline) sulfatooxovanadium(IV) as a novel antileukemic agent with matrix metalloproteinase inhibitory activity. Clin Cancer Res 7:1094
29. Nriagu JO (1998) History, occurrence and uses of vanadium. In: Nriagu JO (ed) Vanadium in the environment. John Wiley and Sons, New York, p 1
30. Ohkawa H, Ohishi N, Yagi K, Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351
31. Okajima T, Nakamura K, Zhang H, Ling N, Tanabe T, Yasuda T, Rosenfeld RG (1992) Sensitive colorimetric bioassays for insulin-like growth factor (IGF) stimulation of cell proliferation and glucose consumption: use in studies of IGF analogs. Endocrinology 130:2201
32. Pandey SK, Théberge JF, Bernier M, Srivastava AK (1999) Phosphatidylinositol 3-kinase requirement in activation of the ras/C-raf-1/MEK/ERK and p70(s6 k) signaling cascade by the insulinomimetic agent vanadyl sulfate. Biochemistry 38:14667
33. Salice VC, Cortizo AM, Gomez Dumm CL, Etcheverry SB (1999) Tyrosine phosphorylation and morphological transformation induced by four vanadium compounds on MC3T3E1 cells. Mol Cell Biochem 198:119
34. Shisheva A, Shechter Y (1992) A cytosolic protein tyrosine kinase in rat adipocytes. FEBS Let 300:93
35. Stein Gs, Lian JB (1993) Molecular mechanism mediating proliferation/differentiation interrelationship during progressive development of the osteoblast phenotype. Endocr Rev 14:424
36. van Engeland M, Kuijpers HJH, Ramaekers FCS, Reutelingsperger ChPM, Schutte B (1997) Plasma membrane alterations and cytoskeletal changes in apoptosis. Exp Cell Res 235:421
37. Varga F, Luegmayr E, Fratzl-Zelman N, Glantschnig H, Ellinger A, Prinz D, Rumpler M, Klaushofer K (1999) Tri-iodothyronine inhibits multilayer formation of the osteoblastic cell line, MC3T3-E1, by promoting apoptosis. J Endocrinol 160:57
38. Wang YZ, Bonner JC (2000) Mechanism of extracellular signal-regulated kinase ERK-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibroblasts. Am J Respir Cell Mol Biol 22:590
39. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331
40. Ye J, Ding M, Leonard SS, Robinson VA, Millecchia L, Zhang X, Castranova V, Vallyathan V, Shi X (1999) Vanadate induces apoptosis in epidermal JB6 P+ cells via hydrogen peroxide-mediated reactions. Mol Cell Biochem 202:9
41. Zamai L, Canonico B, Luchetti F, Ferri P, Melloni E, Guidotti L, Cappellini A, Cutroneo G, Vitale M, Papa S (2001) Supravital exposure to propidium iodide identifies apoptosis on adherent cells. Cytometry 44:57
42. Zhang Z, Huang C, Li J, Leonard SS, Lanciotti R, Butterworth L, Shi X (2001) Vanadate-induced cell growth regulation and the role of reactive oxygen species. Arch Biochem Biophys 392:311-320