Plasminogen activator inhibitor-1 4G/5G gene polymorphism in patients with myocardial or cerebrovascular infarction in Tianjin, China

Chinese Medical Journal

Volumn 116, Issue 11, 2003, Pages 1707-1710

  Zhan, Mei ^a   Zhou, Yuling ^a   Zhongchao, Han ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

Cerebral infarction; Myocardial infarction; Plasminogen activator inhibitor 1; Polymorphism

Indexed keywords

DNA; GLUCOSE; GUANINE; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRIACYLGLYCEROL;

ADULT; AGED; ALLELE; ARTICLE; BRAIN INFARCTION; CHINA; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA POLYMORPHISM; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENE LOCATION; GENETIC RISK; GENETIC TRANSCRIPTION; GENOTYPE; GLUCOSE BLOOD LEVEL; HEART DISEASE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CEREBRAL INFARCTION; CHINA; FEMALE; GENE DELETION; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, GENETIC;

EID: 0348156876     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Ginsbueg D, Zeheb R, Yang AY, et al. CDNA cloning of human plasminogen activator inhibitor from endothelial cells. J Clin Invest 1996;78:1673-1680.
2. Ny T, Sawdey M, Lawrence D, et al. Cloning and sequence of a cDNA coding for the human B-migrating endothelial-cell-type plasminogen activator inhibitor. Proc Natl Acad Sci U S A 1986;83:6776-6780.
3. Pannekoek H, Veerman H, Lambers H, et al. Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family. EMBO J 1986;5:2539-2544.
4. Kruithof EKO, Tran-Thang C, Raansjin A, et al. Demonstration of the fast-acting inhibitor of plasminogen activators in human plasma. Blood 1998;64:907-913.
5. Thorsen S, Philips M, Selmer J, et al. Kinetics of inhibition of tissue-type and urokinase-type plasminogen. Eur J Biochem 1988;175:33-39.
6. Pawse AR, Tarachand U. Clot of plasminogen activator inhibitors in haemostasis and therapy. Indian J Exp Bio 1997; 35:545-552.
7. Wiman B. Plasminogen activator inhibitor-1 in thrombotic disease. Curr opin in hematol 1996;3:372-378.
8. Farb A, Burke AP, Kolodgie FD, et al. Plasminogen activator inhibitor-1 is a determinant of coronary thrombosis in sudden cardiac death. JACC 1996;27:S108.
9. Dawson SJ, Wiman B, Hamsten A, et al. The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem 1993;268:10739-10745.
10. Eriksson P, Kallin B, van't Hooft FM, et al. Allele-specific increases in basal transcription of the plasminogen activator inhibitor-1 gene is associated with myocardial infarction. Proc Natl Acad Sci U S A 1995;92:1851-1855.
11. Contant G, Martinoli JL. Determination of plasminogen activator inhibitor (PAI) activity of human plasma after dilution in a PAI-depleted plasma. Thromb Res 1989;56: 377-386.
12. Junker R, Nabavi DG, Wolff E, et al. Plasminogen activator-1 4G/5G-genotype is associated with cerbral sinus thormbosis in factor V Leiden carriers. Thromb Haemost 1998;80:706-707.
13. Zoller B, Garci de Frutos P, Dahlbak B. A common 4G allele in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene as a risk factor for pulmonary embolism and arterial thrombosis in hereditary protein S deficiency. Thromb Haemost 1998;79:802-807.
14. Segui R, Estelle A, Mira Y, et al. PAI-1 promoter 4G/5G genotype as an additional risk factor for venous thrombosis in subjects with genetic thrombophilic defects. Br J Haematol 2000;111:122-128.
15. Burzotta F, Dicastelnuovo A, Amore A, et al. 4G/5G promoter PAI-1 gene polymorphism is associated with plasmatic PAI-1 activity in Italians: a model of gene-environment interaction. Thromb Haemost 1998;79:354-358.