Fluorescence diagnosis with 5-ALA thermogel of cervical intraepithelial neoplasia;Fluoreszenzdiagnostik mit 5-ALA-thermogel bei zervikaler intraepithelialer neoplasie

Gynakologisch-geburtshilfliche Rundschau

Volumn 44, Issue 1, 2004, Pages 31-37

  Andikyan, Vaagn ^a,d   Kronschnabl, Manuela ^a   Hillemanns, Marija ^c   Wang, Xiuli ^a   Stepp, Herbert ^b   Hillemanns, Peter ^a,b  

^a Klin Poliklin F F   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Russische Akad der Wissenschaften ^*  (Russian Federation)

Author keywords

5 Aminolevulinic acid thermogel; Cervical intraepithelial neoplasia; Fluorescence spectrometry; Photodynamic diagnosis; Photodynamic therapy

Indexed keywords

AMINOLEVULINIC ACID; PORPHYRIN;

ARTICLE; BODY TEMPERATURE; CANCER DIAGNOSIS; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM; FEMALE; FLUORESCENCE; FLUORESCENCE MICROSCOPY; GEL; HISTOLOGY; HUMAN; INTERMETHOD COMPARISON; LIQUID; ROOM TEMPERATURE; SPECTROMETRY; STATISTICAL SIGNIFICANCE; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CONIZATION; UTERINE CERVIX DYSPLASIA;

ADULT; AMINOLEVULINIC ACID; BIOPSY; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; CONIZATION; DATA INTERPRETATION, STATISTICAL; FEMALE; GELS; HUMANS; MIDDLE AGED; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLOXAMER; PORPHYRINS; SPECTROMETRY, FLUORESCENCE; TIME FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 0348140701     PISSN: 10188843     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074315     Document Type: Article

References (14)

1. Brenner H, Wiebelt H, Ziegler H: Fortschritte in der Früherkennung des Zervixkarzinoms aus der Sicht des saarländischen Krebsregisters. Gynecol Oncol 1990;42:48-53.
2. Kennedy J, Pottier R: Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. J Photochem Photobiol 1992;14:275-292.
3. Hillemanns P, Korell M, Schmitt-Sody M, Baumgartner R, Beyer W, Kimmig R, Untch M, Hepp H: Photodynamic therapy in women with cervical intraepithelial neoplasia using topically applied 5-aminolevulinic acid. Int J Cancer 1999;81:34-38.
4. Wierrani F, Kubin A, Jindra R, Henry M, Gharehbaghi K, Grin W, Soltz-Szotz J, Alth G, Gruneberger W: 5-Aminolevulinic acid-mediated photodynamic therapy of intraepithelial neoplasia and human papillomavirus of the cervix - A new experimental approach. Cancer Detect Prev 1999;23:351-355.
5. Pahernik S, Botzlar A, Hillemanns P, Dellian M, Kirschstein M, Abels C, Korell M, Mueller-Hoecker J, Untch M, Goetz A: Pharmacokinetics and selectivity of aminolevulinic acid-induced porphyrin synthesis in patients with cervical intra-epithelial neoplasia. Int J Cancer 1998;78:310-314.
6. Hillemanns P, Thaler C, Kimmig R: Epidemiologie und Diagnostik der zervikalen intraepithelialen Neoplasie: Ist das derzeitige Konzept von Screening und Diagnostik noch aktuell? Gynäkol Geburtshilfliche Rundsch 1997;37:179-190.
7. Rossi F, Campbell D, Pottier R, Kennedy J, Gudgin Dickson E: In vitro studies on the potential use of 5-aminolaevulinic acid-mediated photodynamic therapy for gynaecological tumours. Br J Cancer 1996;74:881-887.
8. Weingandt H: In vitro Fluoreszenzuntersuchungen des endogenen Photosensibilisators Protoporphyrin IX; Diplomarbeit, Institut für Pathologie der Universität Regensburg, 1995.
9. Fukuda H, Battle M, Riley P: Kinetics of porphyrin accumulation in cultured epithelial cells exposed to ALA. Int J Biochem 1993;25:1407-1410.
10. He D, Karas E, Sassa S, Lim H: Porphyrin synthesis by murine epidermal cells. Skin Pharmacol 1993;6:20-25.
11. He D, Sassa S, Lim H: Effect of UVA and blue light on porphyrin biosynthesis on epidermal cells. Photochem Photobiol 1993;57:825-829.
12. Iinuma S, Farshi S, Ortel B, Hasan T: A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin. Br J Cancer 1994;70:21-28.
13. Bedwell J, MacRobert A, Phillips D, Bown S: Fluorescence distribution and photodynamic effect of ALA-induced PPIX in the DMH rat colonic tumour model. Br J Cancer 1992;65:818-824.
14. Ash D, Brown S: New drugs and future developments in photodynamic therapy. Eur J Cancer 1993;29A:1781-1783.