Cholesterol bound to hemoglobin in normal human erythrocytes: A new form of cholesterol in circulation?

Clinical Biochemistry

Volumn 37, Issue 1, 2004, Pages 22-26

  Nikolić, Milan ^a   Stanić, Dragana ^b   Antonijević, Nadežda ^c   Niketić, Vesna ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b IHTM   (Yugoslavia)

^c Health Center New Belgrade   (Yugoslavia)

Author keywords

Cholesterol; HDL cholesterol; Hemoglobin; Hemoglobin lipid; Red blood cells; Seasonal variation

Indexed keywords

HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPID; TRIACYLGLYCEROL;

ADULT; ARTICLE; CELL LEVEL; CHOLESTEROL BLOOD LEVEL; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; HEMOLYSATE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; SEASONAL VARIATION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0348111560     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2003.10.002     Document Type: Article

References (25)

1. Dodge J.T., Mitchell C., Hanahan D.J. The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. Arch. Biochem. Biophys. 100:1963;119-130.
2. Reed C.F., Swisher S.N., Marinetti G.V., Eden E.G. Studies of the lipids of the erythrocyte: I. Quantitative analysis of the lipids of normal human red blood cells. J. Lab. Clin. Med. 56:1960;281-289.
3. Cooper R.A., Arner E.C., Wiley J.S., Shattil S.J. Modification of red cell membrane structure by cholesterol-rich lipid dispersions. A model for the primary spur cell defect. J. Clin. Invest. 55:1975;115-126.
4. Bagdade J.D., Ways P.O. Erythrocyte membrane lipid composition in exogenous and endogenous hypertriglyceridemia. J. Lab. Clin. Med. 75:1970;53-60.
5. Lange Y., Molinaro A.L., Chauncey T.R., Steck T.L. On the mechanism of transfer of cholesterol between human erythrocytes and plasma. J. Biol. Chem. 258:1983;6920-6926.
6. Prisco D., Rogasi P.G., Paniccia R., Abbate R., Gensini G.F. Age-related changes in red blood cell lipids. Angiology. 42:1991;316-322.
7. Rose H.G., Oklander M. Improved procedures for the extraction of lipids from human erythrocytes. J. Lipid Res. 6:1965;428-431.
8. Niketić V., Marić S., Diklić A., Nešković S., Tomašević N. Modified hemoglobin in hypoglycemia caused by hyperinsulinism. Clin. Chim. Acta. 197:1991;47-58.
9. Niketić V., Tomašević N., Nikolić M. Covalent glycoinositolphospholipid binding to hemoglobin: a new post-translational modification of Hb occurring in hyperinsulinism with concomitant hypoglycemia. Biochem. Biophys. Res. Commun. 239:1997;435-438.
10. Tomašević N., Nikolić M., Klappe K., Hoekstra D., Niketić V. Insulin-induced lipid binding to hemoglobin. J. Serb. Chem. Soc. 68(1):2003;25-33.
11. Dawson R.M.C., Hemington N., Lindsay D.B. The phospholipids of the erythrocyte "ghosts" of various species. Biochem. J. 77:1960;226-230.
12. 2+ precipitation procedure for quantitation of high-density lipoprotein cholesterol. Clin. Chem. 28:1982;1379-1388.
13. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18:1972;499-502.
14. Bottcher C.J.F., Van Gent C.M., Pries C. Micromethod for lipid phosphorus determination. Anal. Chim. Acta. 24:1961;203-204.
15. Markwell M.A., Haas S.M., Bieber L.L., Tolbert N.E. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87:1978;206-210.
16. Tentori L., Salvati A.M. Hemoglobinometry in human blood. Antonini E., Rossi-Bernardi L., Chiancone E. Methods in Enzymology. 76:1981;712-713 Academic Press, New York.
17. Bluher M., Hentschel B., Rassoul F., Richter V. Influence of dietary intake and physical activity on annual rhythm of human blood cholesterol concentrations. Chronobiol. Int. 18:2001;541-557.
18. Shahar D.R., Froom P., Harari G., Yerushalmi N., Lubin F., Kristal-Boneh E. Changes in dietary intake account for seasonal changes in cardiovascular disease risk factors. Eur. J. Clin. Nutr. 53:1999;395-400.
19. Mustad V., Derr J., Reddy C., Pearson T.A., Kris-Etherton P.M. Seasonal variation in parameters related to coronary heart disease risk in young men. Atherosclerosis. 126:1996;117-129.
20. Folch J., Lees M., Stanley G.H.S. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:1957;497-502.
21. Dougherty R.M., Galli C., Ferro-Luzzi A., Iacono J.M. Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USA. Am. J. Clin. Nutr. 45:1987;443-455.
22. Blanco-Molina A., Castro G., Martin-Escalante D., Bravo D., Lopez-Miranda J., Castro P.et al. Effects of different dietary cholesterol concentrations on lipoprotein plasma concentrations and on cholesterol efflux from Fu5AH cells. Am. J. Clin. Nutr. 68:1998;1028-1033.
23. Anderson K.M., Castelli W.P., Levy D. Cholesterol and mortality: 30 years of follow-up from the Framingham study. JAMA. 257:1987;176-280.
24. Price M.J., Shah P.K. New strategies in managing and preventing atherosclerosis: focus on HDL. Rev. Cardiovasc. Med. 3:2002;129-137.
25. Summary of the second report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel II). JAMA. 269:1993;3015-3023.