Notch1 Competes with the Amyloid Precursor Protein for γ-Secretase and Down-regulates Presenilin-1 Gene Expression

Journal of Biological Chemistry

Volumn 278, Issue 48, 2003, Pages 47370-47375

  Lleó, Alberto ^a   Berezovska, Oksana ^a   Ramdya, Pavan ^a   Fukumoto, Hiroaki ^a   Raju, Susan ^a   Shah, Tejal ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GENES; PROTEINS; REDUCTION;

NOTCH SIGNALING PATHWAYS;

BIOCHEMISTRY;

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PRESENILIN 1;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BETA-GALACTOSIDASE; BINDING, COMPETITIVE; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; DOWN-REGULATION; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEEDBACK, BIOCHEMICAL; HUMANS; LUCIFERASES; MEMBRANE PROTEINS; MICE; PLASMIDS; PRESENILIN-1; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0348111479     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308480200     Document Type: Article

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