Parathyroid hormone-related protein (PTHRP) is responsible for production of bone metastasis, but not visceral metastasis, by human small cell lung cancer SBC-5 cells in natural killer cell-depleted scid mice

International Journal of Cancer

Volumn 108, Issue 4, 2004, Pages 511-515

  Miki, Toyokazu ^a   Yano, Seiji ^a   Hanibuchi, Masaki ^a   Kanematsu, Takanori ^a   Muguruma, Hiroaki ^a   Sone, Saburo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Bone metastasis; PTHrP; Small cell lung cancer

Indexed keywords

CALCIUM; CYTOKINE; NEUTRALIZING ANTIBODY; PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE METASTASIS; CALCIUM BLOOD LEVEL; CANCER CELL CULTURE; CARCINOGENESIS; CELL PROLIFERATION; COMBINED IMMUNODEFICIENCY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EVALUATION; FOLLOW UP; HUMAN; HUMAN CELL; IN VITRO STUDY; INJECTION; KIDNEY METASTASIS; LIVER METASTASIS; LUNG METASTASIS; LUNG SMALL CELL CANCER; LYMPH NODE METASTASIS; MALE; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; VISCERAL METASTASIS;

ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BONE NEOPLASMS; CALCIUM; CARCINOMA, SMALL CELL; CELL DIVISION; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KIDNEY NEOPLASMS; KILLER CELLS, NATURAL; LIVER NEOPLASMS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, INBRED ICR; MICE, SCID; PARATHYROID HORMONE-RELATED PROTEIN; TUMOR CELLS, CULTURED;

EID: 0348048481     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11586     Document Type: Article

References (29)

1. Quint LE, Francis IR, Wahl RL, Gross BH. Imaging of lung cancer: lung cancer, principles and practice. Philadelphia: Lippincott-Raven, 1996. 437-70.
2. Travis WD, Linder J, Mackay B. Classification, histology, cytology, and electron microscopy: lung cancer, principles and practice. Philadelphia: Lippincott-Raven, 1996. 361-95.
3. Sullivan FJ. Palliative radiotherapy for lung cancer: lung cancer, principles and practice. Philadelphia: Lippincott-Raven, 1996. 775-89.
4. Smith Jr JA. Palliation of painful bone metastases from prostate cancer using sodium etidronate: results of a randomized, prospective, double-blind, placebo-controlled study. J Urol 1989;141:85-7.
5. Stearns ME, Wang M. Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice. Invasion Metastasis 1996;16:116-31.
6. Yoneda T, Sasaki A, Dunstan C, Williams PJ, Bauss F, De Clerck YA, Mundy GR. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2. J Clin Invest 1997;99:2509-17.
7. Theriault RL, Lipton A, Hortobagyi GN, Leff R, Gluck S, Stewart JF, Costello S, Kennedy I, Simeone J, Seaman JJ, Knight RD, Mellars K, et al. Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer Study Group. J Clin Oncol 1999;17:846-54.
8. Roodman GD. Biology of osteoclast activation in cancer. J Clin Oncol 2001:19:3562-71.
9. Iguchi H, Tanaka S, Ozawa Y, Kashiwakuma T, Kimura T, Hiraga T, Ozawa T, Kono T. An experimental model of bone metastasis by human lung cancer cells: the role of parathyroid hormone-related protein in bone metastasis. Cancer Res 1996;56:4040-3.
10. Miki T, Yano S, Hanibuchi M, Sone S. Bone metastasis model with multiorgan dissemination of human small cell lung cancer (SBC-5) cells in natural killer cell-depleted SCID mice. Oncol Res 2000;12:209-17.
11. Tanaka T, Kitamura F, Nagasaka Y, Kuida K, Suwa H, Miyasaka M. Selective long-term elimination of natural killer cells in vivo by an anti interleukin 2 receptor β chain monoclonal antibody in mice. J Exp Med 1993;178:1103-7.
12. Iguchi H, Onuma E, Sato K, Sato K, Ogata E. Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen. Int J Cancer 2001;94:24-7.
13. Green LM, Reade JL, Ware CF. Rapid colorimetric assay for cell viability: application to quantitation of cytotoxic and growth-inhibitory lymphokines. J Immunol Methods 1984;70:257-68.
14. Yano S, Nishioka Y, Izumi K, Tsuruo T, Tanaka T, Miyasaka M, Sone S. Novel metastasis model of human lung cancer in SCID mice depleted of NK cells. Int J Cancer 1996;67:211-7.
15. Iwamura M, Abrahamsson PA, Foss KA, Wu G, Cockett AT, Deftos LJ. Parathyroid hormone-related protein: a potential autocrine growth regulator in human prostate cancer cell lines. Urology 1994;43:675-9.
16. Tovar Sepulveda VA, Falzon M. Parathyroid hormone-related protein enhances PC-3 prostate cancer cell growth via both autocrine/paracrine and intracrine pathways. Regul Pept 2002;105:109-20.
17. Gujral A, Burton DW, Terkeltaub R, Deftos LJ. Parathyroid hormone-related protein induces interleukin 8 production by prostate cancer cells via a novel intracrine mechanism not mediated by its classical nuclear localization sequence. Cancer Res 2001;61:2282-8.
18. Dougherty KM, Blomme EA, Koh AJ, Henderson JE, Pienta KJ, Rosol TJ, McCauley LK. Parathyroid hormone-related protein as a growth regulator of prostate carcinoma. Cancer Res 1999;59:6015-22.
19. Mukaida N, Okamoto SI, Ishikawa Y, Matsushima K. Molecular mechanism of interleukin-8 gene expression. J Leukoc Biol 1994;56:554-8.
20. Orr FW, Lee J, Duivenvoorden WC, Singh G. Pathophysiologic interactions in skeletal metastasis. Cancer 2000;88:2912-8.
21. Fidler IJ, Ellis LM. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 1994;79:185-8.
22. Yoneda T, Michigami T, Yi B, Williams PJ, Niewolna M, Hiraga T. Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma. Cancer 2000;88:2979-88.
23. Suva LJ, Winslow GA, Wettenhall RE, Hammonds RG, Moseley JM, Diefenbach-Jagger H, Rodda CP, Kemp BE, Rodriguez H, Chen EY, Hudson PJ, Martin TJ, et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science 1987;237:893-6.
24. Mundy, G.R. Mechanism of osteolytic bone destruction. Bone 1991;12:S1-6.
25. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 1992;257:88-91.
26. Roodman GD. Role of cytokines in the regulation of bone resorption. Calcif Tissue Int 1993;53:S94-8.
27. Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Yamada Y, Koishihara Y, Ohsugi Y, Kumaki K, Taga T, Kishimoto T, Suda T. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6. Proc Natl Acad Sci USA 1993;90:11924-8.
28. Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol 1990;144:4226-30.
29. Yano S, Nishioka Y, Nokihara H, Sone S. Macrophage colony-stimulating factor gene transduction into human lung cancer cells differentially regulates metastasis formations in various organ microenvironments of natural killer cell-depleted SCID mice. Cancer Res 1997;57:784-90.