Metal Chelation Therapy for Alzheimer Disease

Archives of Neurology

Volumn 60, Issue 12, 2003, Pages 1678-1679

  Rosenberg, Roger N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CLIOQUINOL; COPPER; CYANOCOBALAMIN; FOLIC ACID; ZINC;

ALZHEIMER DISEASE; CHELATION THERAPY; CLINICAL TRIAL; COGNITIVE DEFECT; COPPER BLOOD LEVEL; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; EDITORIAL; HUMAN; MENINGOENCEPHALITIS; NEUROTOXICITY; PATIENT MONITORING; PRIORITY JOURNAL; PROTEIN DETERMINATION; SCORING SYSTEM; SUBACUTE MYELOOPTIC NEUROPATHY; TREATMENT OUTCOME; VACCINATION; ZINC BLOOD LEVEL;

ALZHEIMER DISEASE; CHELATING AGENTS; CHELATION THERAPY; CLIOQUINOL; HUMANS; ZINC;

EID: 0348015824     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.60.12.1678     Document Type: Editorial

References (7)

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3. Ritchie CW, Bush AI, Mackinnon A, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Aβ amyloid depostion and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 2003;60:1685-1691.
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5. Bush AI. The metallobiology of Alzheimer's disease. Trends Neurosci. 2003;26:207-214.
6. Cherny RA, Legg JT, McLean CA, et al. Aqueous dissolution of Alzheimers disease Aβ amyloid deposits by biometal depletion. J Biol Chem. 1999;274:23223-23228.
7. Cherny RA, Atwood CS, Xilinas ME. Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 2001;30:665-676.