Development of a perillyl alcohol topical cream formulation

International Journal of Pharmaceutics

Volumn 269, Issue 2, 2004, Pages 373-383

  Gupta, Abhishek ^a   Myrdal, Paul B ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Perillyl alcohol; Reverse phase HPLC assay; Stability; Topical cream formulation

Indexed keywords

ANTINEOPLASTIC AGENT; PERILLYL ALCOHOL; PLACEBO; TERPENE DERIVATIVE;

ARTICLE; CREAM; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IONIC STRENGTH; PH; PHYSICAL CHEMISTRY; PREFORMULATION; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; TOPICAL TREATMENT;

EID: 0347990424     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.09.026     Document Type: Article

References (18)

1. Barthelman M., Chen W., Gensler H.L., Huang C., Dong Z., Bowden G.T. Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation. Cancer Res. 58:1998;711-716.
2. Boyd A.A., Villenave E., Lesclaux R. Self- and cross-reactions of β-hydroxyperoxy radicals of relevance to tropospheric monoterpene oxidation: structure-activity relationships for rate coefficients. Atmos. Environ. 37:2003;2751-2760.
3. Carstensen, J.T., 1995. Drug stability: principle and practices second edition, revised and expanded. In: Swarbrick, J. (Ed.), Drug and the Pharmaceutical Sciences: A Series of Textbooks and Monographs, vol. 68. Mercel Dekker, New York.
4. Connors, K.A., Amidon, G.L., Stella, V.J., 1986. Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists, 2nd ed. John Wiley and Sons, New York.
5. Crowell P.L., Gould M.N. Chemoprevention and therapy of cancer by D-limonene. Crit. Rev. Oncog. 5:1994;1-22.
6. Elson C.E., Maltzman C.A., Boston J.E., Tanner M.N., Gould M.N. Anti-carcinogenic activity of D-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis. Carcinogenesis. 9:1988;331-332.
7. Ferreira A.C.S., Pinho P.G.D., Rodrigues P., Hogg T. Kinetics of oxidative degradation of white wines and how they are affected by selected technological parameters. J. Agric. Food Chem. 50:2002;5919-5924.
8. Haag J.D., Lindstrom M.J., Gould M.N. Limonene-induced regression of mammary carcinomas. Cancer Res. 52:1992;4021-4026.
9. Lempers H.E.B., Sheldon R.A. Allylic oxidation of olefins to the corresponding α, β-unsaturated ketones catalyzed by chromium aluminophosphate-5. Appl. Catal. A. 143:1996;137-143.
10. Martin, A., 1993. Physical Pharmacy, 4th ed. Lea & Febiger, Philadelphia.
11. Mills J.J., Chari R.S., Boyer I.J., Gould M.N., Jirtle R.L. Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res. 55:1995;979-983.
12. Prevatt M.L., Morreale J., Gregus J., Alberts D.S., Kaper F., Giaccia A., Powell M.B. Effects of perillyl alcohol on melanoma in the Tpras mouse model. Cancer Epidem. Biomar. 11:2002;573-579.
13. Sakaguchi S., Nishiyama Y., Ishii Y. Selective oxidation of monoterpenes with hydrogen peroxide catalyzed by peroxotungstophosphate. J. Org. Chem. 61:1996;5307-5311.
14. Santos I.C.M.S., Simoes M.M.Q., Pereira M.M.M.S., Martins R.R.L., Neves M.G.P.M.S., Cavaleiro J.A.S., Cavaleiro A.M.V. Oxidation of monoterpenes with hydrogen peroxide catalyzed by Keggin-type tungstoborates. J. Mol. Catal. A: Chem. 195:2003;253-262.
15. Schoflied L.J., Kerton O.J., McMorn P., Bethell D., Ellwood S., Hutchings G.J. Oxidation of α-hydroxy containing monoterpenes using titanium silicate catalysts: comments on regioselectivity and the role of acidity. J. Chem. Soc. Perkin Trans. 2:2002;1475-1481.
16. Silva M.J.D., Dutenhefner P.R., Menini L., Gusevskaya E.V. Cobalt catalyzed autoxidation of monoterpenes in acetic acid and acetonitrile solutions. J. Mol. Catal. A: Chem. 201:2003;71-77.
17. Wattenberg L.W. Inhibition of neoplasia by minor dietry constituents. Cancer Res. 43:1983;2448s-2453s.
18. Ziegler M., Brandauer H., Ziegler E., Ziegler G. A different aging model for orange oil: deterioration products. J. Ess. Oil Res. 3:1991;209-220.