Nonsyndromic Genetic Predisposition to Aortic Dissection: A Newly Recognized, Diagnosable, and Preventable Occurrence in Families

Annals of Emergency Medicine

Volumn 43, Issue 1, 2004, Pages 79-82

  Hasham, Sumera N ^a   Lewin, Matthew R ^c   Tran, Van T ^a   Pannu, Hariyadarshi ^a   Muilenburg, Ann ^b   Willing, Marcia ^b   Milewicz, Dianna M ^a,d  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MSB 1614 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AORTA DISSECTION; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CASE REPORT; CLINICAL FEATURE; EMERGENCY WARD; FAMILIAL DISEASE; FAMILY HISTORY; GENETIC PREDISPOSITION; HUMAN; MALE; MARFAN SYNDROME; NONSYNDROMIC FAMILIAL AORTA DISSECTION; NONSYNDROMIC FAMILIAL THORACIC AORTA ANEURYSM; NONSYNDROMIC FAMILIAL THORACIC AORTA DISSECTION; PEDIGREE; PRIORITY JOURNAL; SUDDEN DEATH; THORACIC AORTA ANEURYSM; THORAX PAIN;

EID: 0347989583     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-0644(03)00818-7     Document Type: Article

References (15)

1. McKusick VA. The Marfan Syndrome. In: Beighton P, ed. Heritable Disorders of Connective Tissue. St. Louis, MO: Mosby; 1993;51-135
2. Biddinger A, Rocklin M, Coselli J, et al. Familial thoracic aortic dilatations and dissections: a case control study J Vasc Surg. 1997;25:506-511.
3. Coady MA, Davies RR, Roberts M, et al. Familial patterns of thoracic aortic aneurysms. Arch Surg. 1999;134:361-367.
4. Milewicz DM, Chen H, Park ES, et al. Reduced penetrance and variable expressivity of familial thoracic aortic aneurysms/dissections. Am J Cardiol. 1998;82:474-479.
5. Hasham S, Willing M, Guo D, et al. Mapping a locus for familial thoracic aortic aneurysms and dissections (TAAD2) to 3p24-25. Circulation. 2003;107:3184-3190.
6. Lilienfeld DE, Gunderson PD, Sprafka JM, et al. Epidemiology of aortic aneurysms, I: mortality trends in the United States, 1951 to 1981. Arteriosclerosis. 1987;7:637-643.
7. Klompas M. Does this patient have an acute thoracic aortic dissection? JAMA. 2002;287:2262-2272.
8. Hirata K, Kyushima M, Asato H. Electrocardiographic abnormalities in patients with acute aortic dissection. Am J Cardiol. 1995;76:1207-1212.
9. Guo D, Hasham S, Kuang SQ, et al. Familial thoracic aortic aneurysms and dissections: genetic heterogeneity with a major locus mapping to 5q13-14. Circulation. 2001;103:2461-2468.
10. Vaughan CJ, Casey M, He J, et al. Identification of a chromosome 11q23.2-q24 locus for familial aortic aneurysm disease, a genetically heterogeneous disorder. Circulation. 2001;103:2469-2475.
11. Pyeritz RE, McKusick VA. The Marfan syndrome: diagnosis and management. N Engl J Med. 1979;300:772-777.
12. Milewicz DM, Seidman CE. Genetics of cardiovascular disease 4. Circulation. 2000;102:IV103-IV111.
13. Hasham SN, Guo DO, Milewicz DM. Genetic basis of thoracic aortic aneurysms and dissections. Curr Opin Cardiol. 2002;17:677-683.
14. Kouchoukos NT, Dougenis D. Surgery of the thoracic aorta. N Engl J Med. 1997;336:1876-1888.
15. Hagan PG, Nienaber CA, Isselbacher EM, et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA. 2000;283:897-903.