The transcription factor Snf1p is involved in a Tup1p-independent manner in the glucose regulation of the major methanol metabolism genes of Hansenula polymorpha

Genetics and Molecular Biology

Volumn 26, Issue 4, 2003, Pages 521-528

  Oliveira, Marcos A ^a   Genu, Victor ^a   Salmazo, Anita P T ^a   Carraro, Dirce M ^b   Pereira, Gonçalo A G ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Brazil)

Author keywords

Glucose repression; Hansenula polymorpha; MOX; SNF1; TUP1

Indexed keywords

DIHYDROXYACETONE; GLUCOSE; METHANOL; OXIDOREDUCTASE; SYNTHETASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SNF1P; TRANSCRIPTION FACTOR TUP1P; UNCLASSIFIED DRUG;

ARTICLE; BIOTECHNOLOGY; CONTROLLED STUDY; CULTURE MEDIUM; FUNGAL GENE; GENE ACTIVATION; GENE DISRUPTION; HANSENULA POLYMORPHA; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION; YEAST;

HANSENULA POLYMORPHA; PICHIA; PICHIA ANGUSTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0347989248     PISSN: 14154757     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1415-47572003000400017     Document Type: Article

References (43)

1. Abrams E, Neigeborn L and Carlson M (1986) Molecular analysis of SNF2 and SNF5, genes required for expression of glucose-repressible genes in Saccharomyces cerevisiae. Mol Cell Biol 6:3643-3651.
2. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith AJ and Struhl K (1998) Current Protocols in Molecular Biology, John Wiley & Son, New York, USA.
3. Braun BR and Johnson AD (1997) Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 277:105-109.
4. Bu Y and Schmidt MC (1998) Identification of cis-acting elements in the SUC2 promoter of Saccharomyces cerevisiae required for activation of transcription. Nucleic Acids Res 26:1002-1009.
5. Carlson M, Osmond BC and Botstein D (1981) Mutants of yeast defective in sucrose utilization. Genetics 98:25-40.
6. Cassart JP, Ostling J, Ronne H and Vandenhaute J (1997) Comparative analysis in three fungi reveals structurally and functionally conserved regions in the Mig1 repressor. Mol Gen Genet 255:9-18.
7. Cregg JM and Russell KA (1998) Transformation. Methods Mol Biol 103:27-39.
8. Demasi AP, Pereira GA and Netto LE (2001) Cytosolic thioredoxin peroxidase I is essential for the antioxidant defense of yeast with dysfunctional mitochondria. FEBS Lett 509:430-434.
9. Denis CL and Audino DC (1991) The CCR1 (SNF1) and SCH9 protein kinases act independently of cAMP-dependent protein kinase and the transcriptional activator ADR1 in controlling yeast ADH2 expression. Mol Gen Genet 229:395-399.
10. Flick JS and Johnston M (1990) Two systems of glucose repression of the GAL1 promoter in Saccharomyces cerevisiae. Mol Cell Biol 10:4757-4769.
11. Gancedo JM (1998) Yeast carbon catabolite repression. Microbiol Mol Biol Rev 62,334-361.
12. Gellissen, G. (2000). Heterologous protein production in methylotrophic yeasts. Appl Microbiol Biotechnol 54:741-750.
13. Genu V, Godecke S, Hollenberg CP and Pereira GG (2003) The Hansenula polymorpha MOX gene presents two alternative transcription start points differentially utilized and sensitive to respiratory activity. Eur J Biochem 270:2467-2475.
14. Giuseppin ML, van Eijk HM and Bes BCM (1998) Molecular regulation of methanol oxidase in continuous culture of Hansenula polymorpha. Biotechnol Bioeng 194:577-583.
15. Godecke S, Eckart M, Janowicz ZA and Hollenberg CP (1994) Identification of sequences responsible for transcriptional regulation of the strongly expressed methanol oxidase-encoding gene in Hansenula polymorpha. Gene 139:35-42.
16. Hanks SK and Hunter T (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. Faseb J 9:576-596.
17. Janowicz ZA, Eckart MR, Drewke C, Roggenkamp RO, Hollenberg CP, Maat J, Ledeboer AM, Visser C and Verrips CT (1985) Cloning and characterization of the DAS gene encoding the major methanol assimilatory enzyme from the methylotrophic yeast Hansenula polymorpha. Nucleic Acids Res 13:3043-3062.
18. Kanai T, Ogawa K, Ueda M and Tanaka A (1999) Expression of the SNF1 gene from candida tropicalis is required for growth on various carbon sources, including glucose. Arch Microbiol 172:256-263.
19. Lipke PN and Hull-Pillsbury C (1984) Flocculation of Saccharomyces cerevisiae tup1 mutants. J Bacteriol 159:797-799.
20. Lo WS, Duggan L, Tolga Emre NC, Belotserkovskya R, Lane WS, Shiekhattar R and Berger SL (2001) Snf1-a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription. Science 293:1142-1146.
21. Murad AM, d'Enfert C, Gaillardin C, Tournu H, Tekaia F, Talibi D, Marechal D, Marchais V, Cottin J and Brown AJ (2001) Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1. Mol Microbiol 42:981-993.
22. Navarro B and Igual JC (1994) ADR1 and SNF1 mediate different mechanisms in transcriptional regulation of yeast POT1 gene. Biochem Biophys Res Commun 202:960-966.
23. Ostling J, Carlberg M and Ronne H (1996) Functional domains in the Mig1 repressor. Mol Cell Biol 16:753-761.
24. Ostling J and Ronne H (1998) Negative control of the Mig1p repressor by Snf1p-dependent phosphorylation in the absence of glucose. Eur J Biochem 252:162-168.
25. Pereira GG and Hollenberg CP (1996) Conserved regulation of the Hansenula polymorpha MOX promoter in Saccharomyces cerevisiae reveals insights in the transcriptional activation by Adr1p. Eur J Biochem 238:181-191.
26. Petter R, Chang YC and Kwon-Chung KJ (1997) A gene homologous to Saccharomyces cerevisiae SNF1 appears to be essential for the viability of Candida albicans. Infect Immun 65:4909-4917.
27. Petter R and Kwon-Chung KJ (1996) Disruption of the SNF1 gene abolishes trehalose utilization in the pathogenic yeast Candida glabrata. Infect Immun 64:5269-5273.
28. Roggenkamp R, Janowicz Z, Stanikowski B and Hollenberg CP (1984) Biosynthesis and regulation of the peroxisomal methanol oxidase from the methylotrophic yeast Hansenula polymorpha. Mol Gen Genet 194:489-493.
29. Rohde JR, Trinh J and Sadowski I (2000) Multiple signals regulate GAL transcription in yeast. Mol Cell Biol 20:3880-3886.
30. Schuller HJ and Entian KD (1987) Isolation and expression analysis of two yeast regulatory genes involved in the derepression of glucose-repressible enzymes. Mol Gen Genet 209:66-373.
31. Simon M, Adam G, Rapatz W, Spevak W and Ruis H (1991) The Saccharomyces cerevisiae ADR1 gene is a positive regulator of transcription of genes encoding peroxisomal proteins. Mol Cell Biol 11:699-704.
32. Simon M, Binder M, Adam G, Hartig A and Ruis H (1992) Control of peroxisome proliferation in Saccharomyces cerevisiae by ADR1, SNF1 (CAT1, CCR1) and SNF4 (CAT3). Yeast 8:303-309.
33. Smith TF, Gaitatzes C, Saxena K and Neer EJ (1999) The WD repeat: a common architecture for diverse functions. Trends Biochem Sci 24:181-185.
34. Sprague ER, Redd MJ, Johnson AD and Wolberger C (2000) Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast. Embo J 19:3016-3027.
35. van Dijk R, Faber KN, Kiel JA, Veenhuis M and van der Klei I (2000) The methylotrophic yeast Hansenula polymorpha: a versatile cell factory. Enzyme Microb Technol 26:793-800.
36. Veenhuis M, Sulter G, van der Klei I and Harder W (1989) Evidence for functional heterogeneity among microbodies in yeasts. Arch Microbiol 151:105-110.
37. Veenhuis M, Van Dijken JP and Harder W (1983) The significance of peroxisomes in the metabolism of one-carbon compounds in yeasts. Adv Microb Physiol 24:1-82.
38. Verdoucq L, Vignols F, Jacquot JP, Chartier Y and Meyer Y (1999) In vivo characterization of a thioredoxin h target protein defines a new peroxiredoxin family. J Biol Chem 274:19714-19722.
39. Wach A, Brachat A, Pohlmann R and Philippsen P (1994) New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10:1793-1808.
40. Williams FE and Trumbly RJ (1990) Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae. Mol Cell Biol 10:6500-6511.
41. Yamashiro CT, Ebbole DJ, Lee BU, Brown RE, Bourland C Madi L and Yanofsky C (1996) Characterization of rco-1 of Neurospora crassa, a pleiotropic gene affecting growth and development that encodes a homolog of Tup1 of Saccharomyces cerevisiae. Mol Cell Biol 16:6218-6228.
42. Young ET, Kacherovsky N and Van Riper K (2002) Snf1 protein kinase regulates Adr1 binding to chromatin but not transcription activation. J Biol Chem 277:38095-38103.
43. Zaragoza O, Rodriguez C and Gancedo C (2000) Isolation of the MIG1 gene from Candida albicans and effects of its disruption on catabolite repression. J Bacteriol 182:320-326.