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Volumn 12, Issue 2, 2004, Pages 507-521

Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: Bioisosteric urea replacements

Author keywords

[No Author keywords available]

Indexed keywords

BMS 193885; DICARBOXYLIC ACID DERIVATIVE; DIHYDROPYRIDINE DERIVATIVE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; UREA DERIVATIVE;

EID: 0347951125     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.016     Document Type: Article
Times cited : (74)

References (56)
  • 9
    • 0036826537 scopus 로고    scopus 로고
    • 2 receptor might also be involved in the regulation of energy homeostasis and satiety:
    • 2 receptor might also be involved in the regulation of energy homeostasis and satiety: Herzog H. Drug News Perspt. 15:2002;506.
    • (2002) Drug News Perspt. , vol.15 , pp. 506
    • Herzog, H.1
  • 24
    • 85030919167 scopus 로고    scopus 로고
    • note
    • 2. These descriptors were calculated using Windows XP ACD Software (Version 5).
  • 27
    • 85030922517 scopus 로고    scopus 로고
    • US Patent 3,485,847, 1969
    • Bossert, F., Vater, W. US Patent 3,485,847, 1969.
    • Bossert, F.1    Vater, W.2
  • 35
    • 85030933513 scopus 로고    scopus 로고
    • note
    • An alternative explanation to the enhancement of Caco-2 cell permeabilities for the N-methyl urea derivatives 4b and 8, but not N-methyldihydropyridine 12 could possibly be due to favorable conformational effects and solute volume.
  • 45
    • 85030929324 scopus 로고    scopus 로고
    • note
    • Two isomeric products are theoretically possible from these condensation cyclizations. In both instances it was reasoned the unsubstituted nitrogen (for 34), and the N-alkyl substituted nitrogen (for 35), would be more nucleophilic than the N-aryl nitrogen, and would preferentially participate in the condensation to furnish the desired imidazolone products. Thus, as an example in the formation of 35, isomer i would be preferentially favored over isomer ii. Heteronuclear multiple bond correlation (HMBC) analysis confirmed the structural assignments for both 34 and 35 were correct.
  • 48
    • 85030918006 scopus 로고    scopus 로고
    • note
    • 27a,36.
  • 53
    • 85030921707 scopus 로고    scopus 로고
    • note
    • 6, not all of the 29 carbon resonances could be differentiated with confidence from the solvent baseline and hence only 11 are reported.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.