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85030919167
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note
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2. These descriptors were calculated using Windows XP ACD Software (Version 5).
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26
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85030933513
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note
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An alternative explanation to the enhancement of Caco-2 cell permeabilities for the N-methyl urea derivatives 4b and 8, but not N-methyldihydropyridine 12 could possibly be due to favorable conformational effects and solute volume.
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85030929324
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note
-
Two isomeric products are theoretically possible from these condensation cyclizations. In both instances it was reasoned the unsubstituted nitrogen (for 34), and the N-alkyl substituted nitrogen (for 35), would be more nucleophilic than the N-aryl nitrogen, and would preferentially participate in the condensation to furnish the desired imidazolone products. Thus, as an example in the formation of 35, isomer i would be preferentially favored over isomer ii. Heteronuclear multiple bond correlation (HMBC) analysis confirmed the structural assignments for both 34 and 35 were correct.
-
-
-
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48
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85030918006
-
-
note
-
27a,36.
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85030921707
-
-
note
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6, not all of the 29 carbon resonances could be differentiated with confidence from the solvent baseline and hence only 11 are reported.
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-
-
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