Structure-activity and structure-metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 1, 2004, Pages 281-293

  Mimoto, Tsutomu ^a   Terashima, Keisuke ^a   Nojima, Satoshi ^a   Takaku, Haruo ^a   Nakayama, Mitsunobu ^a   Shintani, Makoto ^a   Yamaoka, Takashi ^a   Hayashi, Hideya ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; INDINAVIR; JE 2147; KNI 764; LOPINAVIR; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (3 CHLOROPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (3 FLUOROPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (3 METHOXYPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (3 METHYLPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (3,4 METHYLENEDIOXYPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (4 CHLOROPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (4 ETHOXYPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (4 FLUOROPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (4 ISOPROPOXYPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (4 METHOXYPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (4 METHYLPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2 METHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (4 N PROPOXYPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2,6 DIMETHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (3 METHOXYPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2,6 DIMETHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (3,4 METHYLENEDIOXYPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N (2,6 DIMETHYLBENZYL) 3 [2 HYDROXY 3 (3 HYDROXY 2 METHYLBENZOYL)AMINO 4 (4 METHOXYPHENYL)BUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SM 319777; SM 322377; STATINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; WILD TYPE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0347931880     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.037     Document Type: Article

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