A new peptide ligand that targets particles and heterologous proteins to hepatocytes in vivo [1]

Molecular Therapy

Volumn 8, Issue 6, 2003, Pages 867-872

  Sokoloff, Alex V ^a   Wong, So C ^b   Ludtke, James J ^a   Sebestyen, Madolna G ^b   Subbotin, Vladimir M ^b   Zhang, Guofeng ^a   Budker, Tatyana ^a   Bachhuber, Marcus ^a   Sumita, Yoshihiro ^c   Wolff, Jon A ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b Mirus Bio Corporation   (United States)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; ASIALOGLYCOPROTEIN RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN M; INTERLEUKIN 1; LIGAND; PEPTIDE DERIVATIVE; PROTEIN DERIVATIVE; PROTEIN P10; PROTEIN P17; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL TISSUE; BACTERIOPHAGE T7; CELL TRANSPORT; CONTROLLED STUDY; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LETTER; LIVER CELL; MACROPHAGE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TISSUE DISTRIBUTION; TWO DIMENSIONAL ELECTROPHORESIS;

ANIMALIA;

EID: 0347917178     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2003.09.009     Document Type: Letter

References (21)

1. Wu, J., Nantz, M. H., and Zern, M. A. (2002). Targeting hepatocytes for drug and gene delivery: emerging novel approaches and applications. Front. Biosci. 7: d717-725.
2. Groman, E. V., Enriquez, P. M., and Josephson, L. (1994). Arabinogalactan for hepatic drug delivery. Bioconj. Chem. 5: 547-556.
3. Lee, Y. C., et al. (1983). Binding of synthetic oligosaccharides to the hepatic gal/GalNAc lectin. J. Biol. Chem. 258: 199-202.
4. Rogers, J. C., and Kornfeld, S. (1971). Hepatic uptake of proteins coupled to fetuin glycoprotein. Biochem. Biophys. Res. Commun. 45: 622-629.
5. Fiume, L., et al. (1988). Inhibition of hepatitis viral replication by vidarabine monophosphate conjugated with lactasaminated serum albumin. Lancet 2: 13-15.
6. Rensen, P. C., et al. (2001). Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo. J. Biol. Chem. 276: 37577-37584.
7. Schlepper-Schafer, J., et al. (1986). Endocytosis via galactose receptors in vivo: ligand size directs uptake by hepatocytes and/or liver macrophages. Exp. Cell Res. 165: 494-506.
8. Furumoto, K., et al. (2001 ). Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver. Biochim. Biophys. Acta 1526: 221-226.
9. Sokoloff, A. V., Bock, I., Zhang, G., Sebestyen, M. G., and Wolff, J. A. (2000). The interactions of peptides with the innate immune system studied with use of T7 phage peptide display. Mol. Ther. 2: 131-139.
10. Sokoloff, A. V., et al. (2001). Specific recognition of protein carboxy-terminal sequences by natural IgM antibodies in normal serum. Mol. Ther. 3: 821-830.
11. Ahearn, J. M., and Rosengard, A. M. (1998). Complement receptors). The Human Complement System in Health and Disease (in J. E. Volanakis, and M. M. Frank, Eds.), pp. 167-202. Dekker, New York.
12. Severin, E., Willers, R., and Bettecken, T. (1984). Flow cytometric analysis of mouse hepatocyte ploidy. II. The development of polyploidy pattern in four mice strains with different life spans. Cell Tissue Res. 238: 649-652.
13. Benkoel, L., et al. (2001). Effect of ischemia-reperfusion on bile canalicular F-actin microfilaments in hepatocytes of human liver allograft: image analysis by confocal laser scanning microscopy. Dig. Dis. Sci. 46: 1663-1667.
14. Weglarz, T. C., Degen, J. L., and Sandgren, E. P. (2000). Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes. Am. J. Pathol. 157: 1963-1974.
15. Alpini, G. P., ??, J. O., Larusso, N. F. (1994). The biology of biliary epithelia. In The Liver: Biology and Pathobiology (I. M. Arias, Ed.), 3rd ed., pp. 623-664. Raven Press, New York.
16. Schneider, G. S., et al. (2003). Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors. Mol. Ther. 7: 35-43.
17. Steven, A. C., et al. (1988). Molecular substructure of a viral receptor-recognition protein: the gp17 tail-fiber of bacteriophage T7. J. Mol. Biol. 200: 351-365.
18. Okuno, K., Nakamura, K., Tanaka, A., Yachi, K., and Yasutomi, M. (1998). Hepatic immunopotentiation by galactose-entrapped liposomal IL-2 compound in the treatment of liver metastases. Surg. Today 28: 64-69.
19. Tomlinson, E. (1987). Theory and practice of site-specific drug delivery. Adv. Drug Delivery Rev. 1: 87-198.
20. Fiume, L., et al. (1992). The pathogenesis of vacuoles produced in rat and mouse liver cells by a conjugate of adenine arabinoside monophosphate with lactosaminated albumin. J. Hepatol. 15: 314-322.
21. Novagen (1999). T7Select System Manual.