-
1
-
-
0000577984
-
The 'one-bead-one-compound' combinatorial library method
-
For recent reviews see: a. Lam, K.S., Lebl, M. and Krchnak, V., The 'one-bead-one-compound' combinatorial library method, Chem. Rev., 97 (1997) 411-448.
-
(1997)
Chem. Rev.
, vol.97
, pp. 411-448
-
-
Lam, K.S.1
Lebl, M.2
Krchnak, V.3
-
2
-
-
0028243847
-
Application of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries
-
b. Gallop, M.A., Barrett, R.W., Dower, W.J., Fodor, S.P.A. and Gordon, E.M., Application of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries, J. Med. Chem., 37 (1994) 1233-1251.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1233-1251
-
-
Gallop, M.A.1
Barrett, R.W.2
Dower, W.J.3
Fodor, S.P.A.4
Gordon, E.M.5
-
3
-
-
7044263277
-
Synthesis and application of small molecule libraries
-
c. Thompson, L.A. and Ellman, J.A., Synthesis and application of small molecule libraries, Chem. Rev., 96 (1996) 555-600.
-
(1996)
Chem. Rev.
, vol.96
, pp. 555-600
-
-
Thompson, L.A.1
Ellman, J.A.2
-
4
-
-
0028076247
-
Recent advances in the generation of chemical diversity libraries
-
d. Desai, M.C., Zuckermann, R.N. and Moos, W.H., Recent advances in the generation of chemical diversity libraries, Drug Dev. Res., 33 (1994) 174-188.
-
(1994)
Drug Dev. Res.
, vol.33
, pp. 174-188
-
-
Desai, M.C.1
Zuckermann, R.N.2
Moos, W.H.3
-
5
-
-
0028555379
-
Simultaneous solid-phase synthesis of β-turn mimetics incorporating side-chain functionality
-
Virgilio, A.A. and Ellman, J.A., Simultaneous solid-phase synthesis of β-turn mimetics incorporating side-chain functionality, J. Am. Chem. Soc., 116 (1994) 11580-11581.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 11580-11581
-
-
Virgilio, A.A.1
Ellman, J.A.2
-
6
-
-
0030064961
-
Solid-supported combinatorial synthesis of structurally diverse β-lactams
-
Ruhland, B., Bhandari, A., Gordon, E.M. and Gallop, M.A., Solid-supported combinatorial synthesis of structurally diverse β-lactams, J. Am. Chem. Soc., 118 (1996) 253-254.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 253-254
-
-
Ruhland, B.1
Bhandari, A.2
Gordon, E.M.3
Gallop, M.A.4
-
7
-
-
0028928237
-
Solid-phase synthesis of structurally diverse 1,4-benzodiazepine derivatives using the Stille coupling reaction
-
a. Plunkett, M.J. and Ellman, J.A., Solid-phase synthesis of structurally diverse 1,4-benzodiazepine derivatives using the Stille coupling reaction, J. Am. Chem. Soc., 117 (1995) 3306-3307.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 3306-3307
-
-
Plunkett, M.J.1
Ellman, J.A.2
-
8
-
-
0030932342
-
Solid-phase synthesis of 1,4-benzodiazepine-2,5-diones. Library preparation and demonstration of synthesis generality
-
b. Boojamra, C.G., Burow, K.M., Thompson, L.A. and Ellman, J.A., Solid-phase synthesis of 1,4-benzodiazepine-2,5-diones. Library preparation and demonstration of synthesis generality, J. Org. Chem., 62 (1997) 1240-1256.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 1240-1256
-
-
Boojamra, C.G.1
Burow, K.M.2
Thompson, L.A.3
Ellman, J.A.4
-
9
-
-
0029883219
-
Palladium-mediated three-component coupling strategy for the solid-phase synthesis of tropane derivatives
-
Koh, J.S. and Ellman, J.A., Palladium-mediated three-component coupling strategy for the solid-phase synthesis of tropane derivatives, J. Org. Chem., 61 (1996) 4494-4495.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 4494-4495
-
-
Koh, J.S.1
Ellman, J.A.2
-
10
-
-
0030600160
-
Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones
-
a. Buckman, B.O. and Mohan, R., Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones, Tetrahedron Lett., 37 (1996) 4439-4442.
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 4439-4442
-
-
Buckman, B.O.1
Mohan, R.2
-
11
-
-
0030599228
-
Solid-phase synthesis of chiral 3-substituted quinazoline-2,4-diones
-
b. Gouilleux, L., Fehrentz, J.-A., Winternitz, F. and Martinez, J., Solid-phase synthesis of chiral 3-substituted quinazoline-2,4-diones, Tetrahedron Lett., 37 (1996) 7031-7034.
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 7031-7034
-
-
Gouilleux, L.1
Fehrentz, J.-A.2
Winternitz, F.3
Martinez, J.4
-
12
-
-
0028873745
-
Design of novel, nonpeptidic thrombin inhibitors and structure of a thrombin-inhibitor complex
-
a. Obst, U., Gramlich, V., Diederich, F., Weber, L. and Banner, D.W., Design of novel, nonpeptidic thrombin inhibitors and structure of a thrombin-inhibitor complex, Angew. Chem. Int. Ed. Engl., 34 (1995) 1739-1742.
-
(1995)
Angew. Chem. Int. Ed. Engl.
, vol.34
, pp. 1739-1742
-
-
Obst, U.1
Gramlich, V.2
Diederich, F.3
Weber, L.4
Banner, D.W.5
-
13
-
-
0029952180
-
Derivatives of 5-amidine indole as inhibitors of thrombin catalytic activity
-
b. Iwanowicz, E.J., Lau, W.F., Lin, J., Roberts, D.G.M. and Seiler, S.M., Derivatives of 5-amidine indole as inhibitors of thrombin catalytic activity, Bioorg. Med. Chem. Lett., 6 (1996) 1339-1344.
-
(1996)
Bioorg. Med. Chem. Lett.
, vol.6
, pp. 1339-1344
-
-
Iwanowicz, E.J.1
Lau, W.F.2
Lin, J.3
Roberts, D.G.M.4
Seiler, S.M.5
-
14
-
-
0029945361
-
Discovery of an orally active non-peptide fibrinogen receptor antagonist
-
Stilz, H.U., Jablonka, B., Just, M., Knolle, J., Paulus, E.F. and Zoller G., Discovery of an orally active non-peptide fibrinogen receptor antagonist, J. Med. Chem., 39 (1996) 2118-2122.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2118-2122
-
-
Stilz, H.U.1
Jablonka, B.2
Just, M.3
Knolle, J.4
Paulus, E.F.5
Zoller, G.6
-
15
-
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0030976794
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Solid-phase synthesis of hydantoin library using a novel cyclization and traceless cleavage step
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Kim, S.W., Ahn, S.Y., Koh, J.S., Lee, J.H., Ro, S. and Cho, H.Y., Solid-phase synthesis of hydantoin library using a novel cyclization and traceless cleavage step, Tetrahedron Lett., 38 (1997) 4603-4606.
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 4603-4606
-
-
Kim, S.W.1
Ahn, S.Y.2
Koh, J.S.3
Lee, J.H.4
Ro, S.5
Cho, H.Y.6
-
16
-
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2342600384
-
-
WO Patent 94/18185
-
Sturzebecher, J., Vieweg, H., Wikstroem, P. and Alder, C., Piperazides of substituted phenylalanine derivates as thrombin inhibitors, WO Patent 94/18185.
-
Piperazides of Substituted Phenylalanine Derivates as Thrombin Inhibitors
-
-
Sturzebecher, J.1
Vieweg, H.2
Wikstroem, P.3
Alder, C.4
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17
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0015931593
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p-Alkoxybenzyl alcohol resin and p-alkoxybenzyl-oxycarbonylhydrazide resin for solid phase synthesis of protected peptide fragments
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a. Wang, S.S., p-Alkoxybenzyl alcohol resin and p-alkoxybenzyl-oxycarbonylhydrazide resin for solid phase synthesis of protected peptide fragments, J. Am. Chem. Soc., 95 (1973) 1328-1333.
-
(1973)
J. Am. Chem. Soc.
, vol.95
, pp. 1328-1333
-
-
Wang, S.S.1
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18
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2342490446
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Wang resin (0.85 mmol/g) was purchased from Advanced ChemTech
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b. Wang resin (0.85 mmol/g) was purchased from Advanced ChemTech.
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19
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2342600821
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Each compound showed a single spot and peak by TLC and HPLC, respectively
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Each compound showed a single spot and peak by TLC and HPLC, respectively.
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