The crystal structure of leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active site

Journal of Biological Chemistry

Volumn 278, Issue 48, 2003, Pages 48219-48227

  Alphey, Magnus S ^a   Williams, Roderick A M ^b   Mottram, Jeremy C ^c   Coombs, Graham H ^b   Hunter, William N ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; CRYSTAL STRUCTURE; DISEASES; HYDROLYSIS; KETONES;

THIOPHILIC ATTACK;

ENZYMES;

3 MERCAPTOPYRUVATE SULFURTRANSFERASE; ARGININE; ASPARTIC ACID; BENZOYLARGININE 4 NITROANILIDE; CARBONYL DERIVATIVE; CYCLOPHILIN; CYSTEINE; HISTIDINE; SERINE; SERINE PROTEINASE; SULFITE; SULFURTRANSFERASE; TACROLIMUS; THIOSULFATE SULFURTRANSFERASE; TOSYLLYSYL CHLOROMETHYL KETONE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CIS TRANS ISOMERISM; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROLYSIS; LEISHMANIA MAJOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CATTLE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROLYSIS; IMMUNOSUPPRESSIVE AGENTS; LEISHMANIA MAJOR; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; SULFURTRANSFERASES; TACROLIMUS; THIOSULFATE SULFURTRANSFERASE;

LEISHMANIA MAJOR; PROTOZOA;

EID: 0347815510     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307187200     Document Type: Article

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