Direct gastrointestinal toxicity of flutamide: Comparison of irradiated and nonirradiated cases

Journal of Urology

Volumn 171, Issue 2 I, 2004, Pages 684-686

  Langenstroer, Peter ^a   Porter, H J ^b   McLeod, David G ^c   Thrasher, J Brantley ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c WALTER REED ARMY MEDICAL CENTER   (United States)

Author keywords

Androgen antagonists; Flutamide; Prostatic neoplasms; Radiation

Indexed keywords

FLUTAMIDE;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; AGED; ANOREXIA; ARTICLE; BEAM THERAPY; CHI SQUARE DISTRIBUTION; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DYSPEPSIA; GASTROINTESTINAL TOXICITY; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION BEAM; VOMITING;

EID: 0347759859     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000106835.60202.81     Document Type: Article

References (7)

1. Eisenberger, M. A., Blumenstein, B. A., Crawford, E. D., Miller, G., McLeod, D. G., Loehrer, P. J. et al: Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl J Med, 339: 1036, 1998
2. Rosenthal, S. A., Linstadt, D. E., Leibenhaut, M. H., Andras, E. J., Brooks, C. P., Stickney, D. R. et al: Flutamide-associated liver toxicity during treatment with total androgen suppression and radiation therapy for prostate cancer. Radiology, 199: 451, 1996
3. Thrasher, J. B., Deeths, J., Bennett, C., Iyer, P., Dineen, M. K., Zhai, S. et al: Comparative study of the clinical efficacy of two dosing regimens of flutamide. Mol Urol, 4: 259, 2002
4. Sogani, P. C., Vagaiwala, M. R. and Whitmore, W. F., Jr.: Experience with flutamide in patients with advanced prostatic cancer without prior endocrine therapy. Cancer, 54: 744, 1984
5. Belanger, A., Giasson, M., Couture, J., Dupont, A., Cusan, L. and Labrie, F.: Plasma levels of hydroxy-flutamide in patients with prostatic cancer receiving the combined hormonal therapy: an LHRH agonist and flutamide. Prostate, 12: 79, 1988
6. Yagoda, A.: Flutamide-induced diarrhea secondary to lactose intolerance. J Natl Cancer Inst, 81: 1839, 1989
7. Soloway, M. S., Schellhammer, P., Sharifi, R., Venner, P., Patterson, A. L., Sarosdy, M. et al: A controlled trial of Casodex (bicalutamide) vs. flutamide, each in combination with luteinising hormone-releasing hormone analogue therapy in patients with advanced prostate cancer. Casodex Combination Study Group. Eur Urol, 29: 105, 1996