Toward a library synthesis of the natural dipeptide antibiotic TAN 1057 A,B

Molecules

Volumn 7, Issue 6, 2002, Pages 469-474

  Aguilar, Nuria ^a   Krüger, Jochen ^a  

^a BAYER AG   (Germany)

Author keywords

Combinatorial chemistry; Dipeptide antibiotics; TAN 1057 A, B

Indexed keywords

ANTIBIOTIC AGENT; DIPEPTIDE; TAN 1057 A B; UNCLASSIFIED DRUG;

ARTICLE; COMBINATORIAL CHEMISTRY; CRYSTALLIZATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID; SOLID;

EID: 0347684576     PISSN: 14203049     EISSN: None     Source Type: Journal    
DOI: 10.3390/70600469     Document Type: Article

References (8)

1. Funabashi, Y.; Tsubotani, S.; Koyama K.; Katayama, N.; Harada, S. Tetrahedron 1993, 49, 13-28.
2. (a) Williams, R. M.; Yuan, C. J. Am Chem. Soc. 1997, 119, 11777-11784
3. (b) Sokolov, V. V.; Kozhushkov, S. I.; Nikolskaya, S.; Belov, V. N.; Es-Sayed, M.; de Meijere, A. Eur. J. Org. Chem. 1998, 777-783
4. (c) For a recent synthesis of the heterocyclic core see: Ganesan, A.; Lin, P. Synthesis 2000, 2127-2130.
5. (a) Katayama, N.; Fukusumi, S.; Funabashi, Y.; Iwahi, T.; Ono, H. J. Antibiotics 1993, 46, 606-613.
6. (b) Williams, R. M.; Yuan, C.; Lee, V. J.; Chamberland, S. J. Antibiotics 1998, 51, 189-201.
7. For analytical purposes we analyzed the natural product and derivatives thereof by ion-pair chromatography, however, effective conditions for preparative RP-HPLC were not found.
8. Dodd, D. S.; Wallace, O. B. Tetrahedron Lett. 1998, 39, 5701-5704.