Effects of intrathecal NMDA and AMPA receptors agonists or antagonists on antinociception of propofol

Acta Pharmacologica Sinica

Volumn 25, Issue 1, 2004, Pages 9-14

  Xu, Ai Jun ^a   Duan, Shi Ming ^a   Zeng, Yin Ming ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

AMPA receptors; Antinociception; N methyl D aspartate receptors; Propofol; Spinal injections

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ACETIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR AGONIST; AMPA RECEPTOR ANTAGONIST; ANTISENSE OLIGODEOXYNUCLEOTIDE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; PROPOFOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; DRUG EFFECT; FEMALE; HOT PLATE TEST; MALE; MOUSE; NONHUMAN; PAIN THRESHOLD; WRITHING TEST;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANALGESICS; ANIMALS; DIZOCILPINE MALEATE; FEMALE; INJECTIONS, SPINAL; MALE; MICE; N-METHYLASPARTATE; NOCICEPTORS; PAIN THRESHOLD; PROPOFOL; QUINOXALINES; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0347655012     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Aanonsen LM, Lei S, Wilcox GL. Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord. Pain 1990; 41: 309-21.
2. Aanonsen LM, Wilcox GL. Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists. J Pharmacol Exp Ther 1987; 243: 9-19.
3. Mjellem JN, Lund A, Berge OG, Hole K. Potentiation of a behavioral response in mice by spinal coadministration of substance P and excitatory amino acid agonists. Neurosci Lett 1991; 133: 121-4.
4. Haley JE, Sullivan AF, Dickenson AH. Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res 1990; 518: 218-26.
5. Nasstrom J, Karlsson U, Post C. Antinociception actions of different classes of excitatory amino acid receptor antagonists in mice. Eur J Pharmacol 1992; 212: 21-9.
6. Bertlik M, Orser BA, Wang LY, Macdonald JF. Propofol selectively inhibits the NMDA subtype of glutamate receptor. Can J Anesth 1994; 41: A6.
7. Orser BA, Bertlik M, Wang LY, Macdonald JF. Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurons. Br J Pharmacol 1995; 116: 1761-8.
8. Bryson HM, Fulton BR, Faulds D. Propofol: an update of use in anesthesia and conscious sedation. Drugs 1995; 50: 513-59.
9. Brian A, Jewett BA, Lisa M, Gibbs BM, Tarasiuk A, Kendig JJ. Propofol and barbiturate depression of spinal nociceptive neurotransmission. Anesthesiology 1992; 77: 1148-54.
10. Wilder-Smith O, Borgeat A. Analgesia with subhypnotic doses of thiopentone and propofol. Br J Anaesth 1991; 67: 226-7.
11. Uchida H, Kishikawa K, Collins JG. Effects of propofol on spinal dorsal horn neurons: comparison with lack of ketamine effects. Anesthesiology 1995; 83: 1312-22.
12. Bansinath M, Shukla VK, Turndorf H. Popofol modulates the effects of chemoconvulsants acting at GABAergic, glycinergic, and glutamate receptor subtypes. Anesthesiology 1995; 83: 809-15.
13. Xu SY, Bian RL, Chen X. Methodology of pharmacological experiments. 3rd ed. Beijing: People's Medical Publishing House; 2002. p 882-7.
14. Song BW, Zhou LL, Wang J, Chen ZW, Ma CG. Intrathecal administration in conscious mice: a simple technique for studying spinally mediated action of analgesics. Chin Pharmacol Bull 1996; 12: 375-6.
15. Rydh-Rinder M, Berge OG, Hokfelt T. Antinociceptive effects after intrathecal administration of phosphodiester-, 2′-O-allyl-, and C-5-propyne-modified antisense oligodeoxynucleotides targeting the NMDAR1 subunit in mouse. Mol Brain Res 2001; 86: 23-33.
16. Anwar MM, Abdel-Rahman MS. Effect of propofol on perception of pain in mice: mechanism of action. Comp Biochem Physiol A Mol Integr Physiol 1998; 120: 249-53.
17. Lutfy K, Weber E. Attenuation of nociceptive responses by ACEA-1021, a competitive NMDA receptor/glycine site antagonist, in the mice. Brain Res 1996; 743: 17-23.
18. Lutfy K, Cai SX, Woodward RM, Weber E. Antinociceptive effects of NMDA and non-NMDA receptor antagonists in the tail flick test in mice. Pain 1997; 70: 31-40.