Pharmacokinetic evaluation of an azithromycin controlled release dosage form in healthy human volunteers: A single dose study

International Journal of Pharmaceutics

Volumn 270, Issue 1-2, 2004, Pages 1-8

  Gandhi, Rajesh ^a   Kaul, Chaman Lal ^a   Panchagnula, Ramesh ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Azithromycin; Controlled release; Pharmacokinetics

Indexed keywords

'VICON'; AZITHROMYCIN;

ABDOMINAL CRAMP; ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIZZINESS; DRUG BLOOD LEVEL; DRUG DOSAGE FORM; HEADACHE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; NAUSEA; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STEADY STATE; VOMITING;

EID: 0347652962     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.09.046     Document Type: Article

References (11)

1. Christopher J.D., Barradel L.B. Azithromycin: a review of its pharmacological properties and use as 3-day therapy in respiratory tract infection. Drugs. 51:1996;483-505.
2. Foulds G., Shepard R.M., Johnson R.B. The pharmacokinetics of azithromycin in human serum and tissues. J. Antimicrob. Chemother. 25:1990;73-82.
3. Gandhi R., Kaul C.L., Panchagnula R. Validated HPLC method for in vitro analysis of azithromycin by using electrochemical detection. J. Pharm. Biomed. Anal. 23:2000;1073-1079.
4. Gibaldi, M., Perrier, D., 1982. Pharmacokinetics. 2nd ed. Marcel Dekker, New York, pp. 182-190.
5. Hardman, J.G., Limbird, L.E., 1996. Antimicrobial agents. In: Gilman, A.G., Rall, T.R., Nies, A.S., Taylore, P. (Eds.), The Pharmacological Basis of Therapeutics. 9th ed. McGraw-Hill, New York, pp. 1135-1140.
6. Kees F., Spanglar S., Wellenhofer M. Determination of macrolides in biological matrices by high performance liquid chromatography with electrochemical detection. J. Chromatogr. 812:1998;287-293.
7. Ritschel W.A. Biopharmaceutics and pharmacokinetic aspects in the design of controlled release peroral drug delivery systems. Drug Dev. Ind. Pharm. 15:1989;1073-1107.
8. Ritschel, W.A., Kearns, G.L., 1999. Pharmacokinetic parameters of important drugs. In Handbook of Basic Pharmacokinetics. American Pharmaceutical Association, Washington, pp. 479-503.
9. Ritschel W.A., Sathyan G. Development and pharmacokinetics evaluation of controlled release dosage form of lithium carbonate in beagle dogs. Lithium. 1:1990;209-214.
10. Swartz M.E., Krull I.S. Validation of chromatographic methods. Pharm. Tech. 22:1998;104-119.
11. USP24/NF19, 2000. US Pharmacopoeial Convention Inc., Rockville, MD, pp. 185-187.