Mammary tumours in female rats developed after 1-methyl-1-nitrosourea treatment

Biologia - Section Cellular and Molecular Biology

Volumn 55, Issue SUPPL. 8, 2000, Pages 63-67

  Líška, Ján ^a   Galbavý, Štefan ^a   Zlatoš, Jozef ^a   Macejová, Danica ^b   Mičincová, Mária ^a   Brtko, Július ^b  

^a Physics and Informatics   (Slovakia)

^b INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

1 methyl 1 nitrosourea; Histopathology; Mammary carcinoma; Sprague Dawley rat

Indexed keywords

EID: 0347646634     PISSN: 13356399     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. GULLINO, P. M., PETTIGREW, H. M. & GRANTHAM, F. H. 1975. N-Nitrosomethylurea as mammary gland carcinogen in rats. J. Natl. Cancer Inst. 54: 401-409.
2. LÍŠKA, J., GALBAVÝ, Š., MACEJOVÁ, D., ZLATOŠ, J. & BRTKO, J. 2000. Histopathology of mammary tumours in female rats treated with 1-methyl-1-nitrosourea. Endocr. Regul. 34: 91-96.
3. MCCORMICK D. L., ADAMOWSKI, C. B., FIKS, A. & MOON, R. C. 1981. Lifetime dose response relationships for mammmary tumor induction by a single administration of N-methyl-N-nitrosourea. Cancer Res. 41: 1690-1694.
4. POHLODEK, K., JANEK, L'., REGENDOVÁ, M., FERIANEC, V., GALBAVÝ, S., BLAŠKO, P., KRIŽKO, M., HOLOMÁN, K. & ZAVIAČIČ, M. 2000. Impact of ultrasound-guided large-core needle biopsy with frozen-section on surgical management of breast cancer, (in Slovak) Slov. Gynek. Pôrod. 7: 62-70.
5. ROSE, D. P., PRUITT, B., STAUBER, P., ERTURK, E. & BRYAN, G. T. 1980. Influence of dosage schedule on the biological characteristics of N-nitrosomethylurea-induced rat mammary tumors. Cancer Res. 40: 235-239.
6. RUSSO, J., RUSSO, I. H., ROGERS, A. E., VAN ZWIETEN, M.J. & GUSTERSON, B. 1990. Tumors of mammary gland, pp 47-78. In: TURUSOV, V. & MOHR, U. (eds) Pathology of Tumours in Laboratory Animals. Vol. 1, Tumours of the Rat, IARC Scientific Publications, Lyon.
7. RUSSO, J., TAY, L. K. & RUSSO, I. H. 1982. Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res. Treatment 2: 5-73.
8. RUSSO, J., WILGUS, G. & Russo, I. H. 1979. Susceptibility of the mammary gland to carcinogenesis. Differentiation of the mammary gland as determinant of tumor incidence and the type of lesion. Am. J. Pathol. 96: 721-734.
9. THOMPSON, H. J. & ADLAKHA, H. 1991. Dose-responsive induction of mammary gland carcinomas by the intraperitoneal injection of of 1-methyl-1-nitrosourea. Cancer Res. 51: 3411-3415.
10. THOMPSON, H. J., MCGINLEY J. N., ROTHHAMMER, K. &: SINGH, M. 1995. Rapid induction of mammary intraductal proliferation, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrosourea. Carcinogenesis 16: 2407-2411.
11. THOMPSON, H. J., MCGINLEY J. N., ROTHHAMMER, K. & SINGH, M. 1998. Ovarian hormone dependence of pre-malignant and malignant mammary gland lesions induced in pre-pubertal rats by 1-methyl-1-nitrosourea. Carcinogenesis. 19: 2407-2411.
12. WELSCH, C. W. 1985. Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins. Cancer Res. 45: 3415-3443.