Modulation of the redox state of tubulin by the glutathione/glutaredoxin reductase system

Biochemical and Biophysical Research Communications

Volumn 314, Issue 2, 2004, Pages 555-560

  Landino, Lisa M ^a   Moynihan, Katherine L ^a   Todd, Jonathan V ^a   Kennett, Kelly L ^a  

^a William and Mary   (United States)

Author keywords

Cysteine oxidation; Disulfides; Glutaredoxin; Glutathione reductase; Glutathionylation; Peroxynitrite; Thiol disulfide exchange; Tubulin

Indexed keywords

5 IODOACETAMIDOFLUORESCEIN; ALPHA TUBULIN; BETA TUBULIN; CYSTEINE; DISULFIDE; FLUORESCEIN DERIVATIVE; GLUTAREDOXIN REDUCTASE; GLUTATHIONE; GLUTATHIONE REDUCTASE; OXIDOREDUCTASE; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CHEMICAL LABELING; CONTROLLED STUDY; DISULFIDE BOND; DOT HYBRIDIZATION; ENZYME ACTIVITY; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN POLYMERIZATION; QUANTITATIVE ANALYSIS; REDUCTION; SWINE; WESTERN BLOTTING;

ESCHERICHIA COLI; SUIDAE;

EID: 0347635415     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.12.126     Document Type: Article

References (22)

1. Brady S., Black M. Axonal transport of microtubule protein: cytotypic variation of tubulin and MAPs in neurons. Ann. NY. Acad. Sci. 466:1986;199-217.
2. Schnapp B.J., Vale R.D., Sheetz M.P., Reese T.S. Single microtubules from squid axoplasm support bidirectional movement of organelles. Cell. 40:1985;455-462.
3. Smith M.A., Richey Harris P.L., Sayre L.M., Beckman J.S., Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci. 17:1997;2653-2657.
4. Aksenov M.Y., Aksenova M.V., Butterfield D.A., Geddes J.W., Markesbery W.R. Protein oxidation in the brain in Alzheimer's disease. Neuroscience. 103:2001;373-383.
5. Landino L.M., Hasan R., McGaw A., Cooley S., Smith A.W., Masselam K., Kim G. Peroxynitrite oxidation of tubulin sulfhydryls inhibits microtubule polymerization. Arch. Biochem. Biophys. 398:2002;213-220.
6. L.M. Landino, J.S. Iwig, K.L. Kennett, K.L. Moynihan, Repair of peroxynitrite damage to tubulin by the thioredoxin reductase system, Free Rad. Biol. Med. 36 (2004) (in press).
7. Luthman M., Holmgren A. Glutaredoxin from calf thymus. J. Biol. Chem. 257:1982;6686-6690.
8. Holmgren A. Thioredoxin and glutaredoxin systems. J. Biol. Chem. 264:1989;13963-13966.
9. Holmgren A., Aslund F. Glutaredoxin. Methods Enzymol. 252:1995;283-292.
10. Williams R.C., Lee J.C. Preparation of tubulin from brain. Methods Enzymol. 85:1982;376-385.
11. Beckman J.S., Chen J., Ischiropoulos H., Crow J.P. Oxidative chemistry of peroxynitrite. Methods Enzymol. 233:1994;229-240.
12. Na G.C., Timasheff S.N. Physical properties of purified calf brain tubulin. Methods Enzymol. 85:1982;393-408.
13. Gilbert H.F. Thiol/disulfide exchange equilibria and disulfide bond stability. Methods Enzymol. 251:1995;8-28.
14. Kirlin W.G., Cai J., Thompson S.A., Diaz D., Kavanagh T.J., Jones D.P. Glutathione redox potential in response to differentiation and enzyme inducers. Free Rad. Biol. Med. 27:1999;1208-1218.
15. Anderson P.J. The structure and amount of tubulin in cells and tissues. J. Biol. Chem. 254:1979;2168-2171.
16. Radi R., Beckman J.S., Bush K.M., Freeman B.A. Peroxynitrite oxidation of sulfhydryls. J. Biol. Chem. 266:1991;4244-4250.
17. Hogg P.J. Disulfide bonds as switches for protein function. Trends Biochem. Sci. 28:2003;210-214.
18. Hess D.T., Matsumoto A., Nudelman R., Stamler J.S. S-nitrosylation: spectrum and specificity. Nat. Cell. Biol. 3:2001;E1-E3.
19. Lipton S.A., Choi Y.-B., Takahashi H., Zhang D., Li W., Godzik A., Bankston L.A. Cysteine regulation of protein function as exemplified by NMDA-receptor modulation. Trends Neurosci. 25:2002;474-480.
20. Dalle-Donne I., Rossi R., Giustarini D., Colombo R., Milzani A. Actin S-glutathionylation: evidence against a thiol-disulphide exchange mechanism. Free Rad. Biol. Med. 35:2003;1185-1193.
21. Lind C., Gerdes R., Hamnell Y., Shuppe-Koistinen, Brockenhuus von Lowenhielm H., Holmgren A., Cotgreave I.A. Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis. Arch. Biochem. Biophys. 406:2002;229-240.
22. Starke D.W., Chock P.B., Mieyal J.J. Glutathione-thiol radical scavenging and transferase properties of human glutaredoxin (thioltransferase). J. Biol. Chem. 278:2003;14607-14613.