Plasmapheresis in C4d-positive Acute Humoral Rejection Following Kidney Transplantation: A Review of 4 Cases

Therapeutic Apheresis

Volumn 7, Issue 6, 2003, Pages 529-535

  Lennertz, Andrea ^a   Fertmann, Jan ^a   Thomae, Robert ^a   Illner, Wolf Dieter ^a   Hillebrand, Günther F ^a   Feucht, Helmut E ^b   Land, Walter ^a   Samtleben, Walter ^a   Bosch, Thomas ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Fachklinik Bad Heilbrunn   (Germany)

Author keywords

Acute Humoral Rejection; C4d positive; Kidney; Plasmapheresis; Transplantation

Indexed keywords

AZATHIOPRINE; CD4 ANTIGEN; CYCLOSPORIN; LYMPHOCYTE ANTIBODY; MONOCLONAL ANTIBODY CD3; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; AUTOIMMUNE DISEASE; CASE REPORT; CELLULAR IMMUNITY; FEMALE; GRAFT REJECTION; HEMODIALYSIS; HUMAN; HUMORAL IMMUNITY; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; PLASMAPHERESIS; PRIORITY JOURNAL; REVIEW;

ACUTE DISEASE; ADULT; ANTIBODY FORMATION; COMBINED MODALITY THERAPY; COMPLEMENT C4; COMPLEMENT C4B; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PLASMAPHERESIS; REOPERATION; RISK ASSESSMENT; SAMPLING STUDIES; TRANSPLANTATION IMMUNOLOGY; TREATMENT OUTCOME;

EID: 0347624663     PISSN: 10916660     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1526-0968.2003.00101.x     Document Type: Review

References (23)

1. Feucht HE, Opelz G. The humoral response towards HLA class II determinants in renal transplantation. Kidney Int 1996;50:1464-75.
2. Böhmig GA, Exner M, Habicht A et al. Capillary C4d deposition in kidney allografts: A specific marker of alloantibody-dependent graft injury. J Am Soc Nephrol 2002;13:1091-9.
3. Regele H, Exner M, Watschinger B et al. Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant 2001;16:2058-66.
4. Collins AB, Schneeberger EE, Pascual MA et al. Complement activation in acute humoral renal allograft rejection. Diagnostic significance of C4d deposits in peritubular capillaries. J Am Soc Nephrol 1999;10:2208-14.
5. Crespo M, Pascual M, Tolkoff-Rubin N et al. Acute humoral rejection in renal allograft recipients: I. incidence, serology and clinical characteristics. Transplantation 2001;71:652-8.
6. Halloran PF, Wadgymar A, Ritchie S, Falk J, Solez K, Srinivasa NS. The significance of anti-class I antibody response. I. Clinical and pathologic features of anti-class I mediated rejection. Transplantation 1990;49:85-91.
7. Halloran PF, Schlaut J, Solez K, Srinivasa NS. The significance of anti-class I antibody response. II. Clinical and pathologic features of renal transplants with anti-class I-like antibody. Transplantation 1992;53:550-5.
8. Lobo PI, Spencer CE, Stevenson WC, Pruett TL. Evidence demonstrating poor kidney graft survival when acute rejections are associated with IgG donor-specific lymphocytotoxin. Transplantation 1995;59:357-60.
9. Trpkov K, Campbell P, Pazderka F, Cockfield S, Solez K, Halloran PF. Pathologic features of acute renal allograft rejection associated with donor-specific antibody. Transplantation 1996;61:1586-92.
10. Terasaki PI, McClelland JD. Microdroplet assay of human serum cytotoxins. Nature 1964;204:998-1000.
11. Feucht HE, Felber E, Gokel MJ et al. Vascular deposition of complement-split products in kidney allografts with cell-mediated rejection. Clin Exp Immunol 1991;86:464-70.
12. Feucht HE, Schneeberger H, Hillebrand G et al. Capillary deposition of C4d complement fragment and early renal graft loss. Kidney Int 1993;43:1333-8.
13. Lederer SR, Schneeberger H, Albert E et al. Early renal graft dysfunction. The role of preformed antibodies to DR-typed lymphoblastoid cell lines. Transplantation 1996;61:313-19.
14. Lederer SR, Kluth-Pepper B, Schneeberger H, Albert E, Land W, Feucht HE. Impact of humoral alloreactivity early after transplantation on the long-term survival of renal allografts. Kidney Int 2001;59:334-41.
15. Pascual M, Saidmann S, Tolkoff-Rubin N et al. Plasma exchange and tacrolimus-mycophenolate rescue for acute humoral rejection in kidney transplantation. Transplantation 1998;66:1460-4.
16. Montgomery RA, Zachary AA, Racusen LC et al. Plasmapheresis and intravenous immune globuline provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients. Transplantation 2000;70:887-95.
17. Persson NH, Bucin D, Ekberg H et al. Immunoadsorption in acute vascular rejection after renal transplantation. Transplant Proc 1995;27:3466.
18. Pretagostini R, Berloco P, Poli L et al. Immunoadsorption with protein A in humoral rejection of kidney transplants. ASAIO J 1998;42:M645-648.
19. Böhmig GA, Regele H, Säemann MD et al. Role of humorel immune reactions as target for antirejection therapy in recipients of a spousal-donor kidney graft. Am J Kidney Dis 2000;35:667-73.
20. Solez K, Axelsen RA, Benediktsson H et al. International standardization of criteria for the histological diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int 1993;44:411-22.
21. Böhmig GA, Regele H, Exner M et al. C4d-positive acute humoral renal allograft rejection: effective treatment by immunoadsorption. J Am Soc Nephrol 2001;12:2482-9.
22. McKenzie IFC, Whittingham S. Deposits of immunoglobulin and fibrin in human allografted kidneys. Lancet 1968;2:1313-16.
23. Böhmig GA, Exner M, Watschinger B et al. C4d deposits in renal allografts are associated with inferior graft outcome. Transplant Proc 2001;33:1151-2.