Evaluation of serum concentrations of biochemical markers of bone metabolism and insulin-like growth factor I associated with treadmill exercise in young horses

American Journal of Veterinary Research

Volumn 64, Issue 12, 2003, Pages 1549-1556

  Jackson, Brendnan F ^a   Goodship, Allen E ^a   Eastell, Richard ^b   Price, Joanna S ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; BIOCHEMICAL MARKER; COLLAGEN TYPE 1; OSTEOCALCIN; PEPTIDE DERIVATIVE; PROCOLLAGEN; SOMATOMEDIN C;

ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BONE CELL; BONE DENSITY; BONE METABOLISM; BONE MINERAL; BONE STRENGTH; BONE TURNOVER; CELL ACTIVITY; CONTROLLED STUDY; CORRELATION FUNCTION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HORSE; NONHUMAN; OSTEOLYSIS; PHALANX; TRAINING; TREADMILL EXERCISE; WALKING;

ALKALINE PHOSPHATASE; AMINO ACIDS; ANIMALS; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DENSITOMETRY, X-RAY; FEMALE; HORSES; INSULIN-LIKE GROWTH FACTOR I; OSTEOCALCIN; PEPTIDE FRAGMENTS; PHYSICAL CONDITIONING, ANIMAL; PROCOLLAGEN;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 0347531493     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2003.64.1549     Document Type: Article

References (56)

1. Nilsson BE, Westlin NE. Bone density in athletes. Clin Orthop 1971;77:179-182.
2. Jones H, Priest J, Hayes W, et al. Humeral hypertrophy in response to exercise. J Bone Joint Surg Am 1977;59A:204-207.
3. Jeffcott LB, Rossdale PD, Frank CJ, et al. An assessment of wastage in Thoroughbred racing from conception to 4 years of age. Equine Vet J 1982;14:185-198.
4. Rossdale PD, Hopes R, Wingfield-Digby NJ, et al. Epidemiological study of wastage among racehorses 1982 and 1983. Vet Rec 1985;116:66-69.
5. Estberg L, Stover SM, Gardner IA, et al. High-speed exercise history and catastrophic racing fracture in Thoroughbreds. Am J Vet Res 1996;57:1549-1555.
6. Cohen ND, Berry SM, Peloso JG, et al. Association of high-speed exercise with racing injury in thoroughbreds. J Am Vet Med Assoc 2000;216:1273-1278.
7. Williams RB, Harkin LS, Hammond CJ, et al. Racehorse injuries, clinical problems and fatalities recorded on British race-courses from flat racing and national hunt racing during 1996, 1997 and 1998. Equine Vet J 2001;33:478-486.
8. Leuken SA, Arnaud SB, Taylor AK, et al. Changes in markers of bone formation and resorption in a bed rest model of weightlessness. J Bone Miner Res 1993;8:1433-1438.
9. Brahm H, Ström H, Piehl-Aulin K, et al. Bone metabolism in endurance trained athletes: a comparison to population-based controls on DXA, SXA, quantitative ultrasound and biochemical markers. Calcif Tissue Int 1997;61:448-454.
10. Etherington J, Keeling J, Bramley R, et al. The effects of 10 weeks military training on heel ultrasound and bone turnover. Calcif Tissue Int 1999;64:389-393.
11. Price JS. Biochemical markers of bone metabolism in horses: potentials and limitations? Vet J 1999;156:163-165.
12. Price JS, Jackson B, Eastell R, et al. The response of the equine skeleton to physical training: a biochemical study in horses. Bone 1995;17:221-229.
13. Bravenboer N, Englebert MJ, Visser NA, et al. The effects of exercise on systemic and bone concentrations of growth factors in rats. J Orthop Res 2001;19:945-949.
14. Yeh JK, Aloia JF, Chen M, et al. Effect of growth hormone administration and treadmill exercise on serum and skeletal IGF-I in rats. Am J Physiol 1994;266:E129-E135.
15. Lean JM, Jagger CJ, Chambers TJ, et al. Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. Am J Physiol 1995;268:E318-E327.
16. Murray RC, Vedi S, Birch HL, et al. Subchondral bone thickness, hardness and remodeling are influenced by short term exercise in a site specific manner. J Orthop Res 2001;19:1035-1042.
17. Murray RC, Birch HL, Lakhani, et al. Biochemical composition of equine carpal articular cartilage is influenced by exercise in a site specific manner. Osteoarthritis Cartilage 2001;9:625-632.
18. Firth EC, Goodship AE, Delahunt J, et al. Osteoinductive response in the dorsal aspect of the carpus of young thoroughbreds in training occurs within months. Equine Vet J Suppl 1999;30:552-554.
19. Murray RC, Whitton RC, Vedi S, et al. The effect of training on the calcified zone of the equine middle carpal articular cartilage. Equine Vet J 1999;suppl 30:274-278.
20. Whitton RC, Murray RC, Buckley C, et al. An MRI study of the effect of treadmill training on bone morphology of the central and third tarsal bones of young thoroughbred horses. Equine Vet J Suppl 1999;30:258-261.
21. Birch HL, McLaughlin L, Smith RK, et al. Treadmill exercise induced tendon hypertrophy: assessment of tendons with different mechanical functions. Equine Vet J 1999;suppl 30:222-226.
22. Murray RC, Zhu CF, Goodship AE, et al. Exercise affects the mechanical properties and histological appearance of equine articular cartilage. J Orthop Res 1999;17:725-31.
23. Reilly GC, Currey JD, Goodship AE. Exercise of young thoroughbreds increases impact strength of the third metacarpal bone. J Orthop Res 1997;15:862-868.
24. Price JS, Jackson B, Eastell R, et al. Age related changes in biochemical markers of bone metabolism. Equine Vet J 1995;27:201-207.
25. Jackson B, Eastell R, Lanyon LE, et al. The measurement of bone specific alkaline phosphatase in the horse: a comparison of two techniques. Res Vet Sci 1996;61:160-164.
26. Colwell A, Eastell R. The renal clearance of free and conjugated pyridinium crosslinks of collagen. J Bone Miner Res 1996; 11:1976-1980.
27. Rubin CT, Bain SD, McLeod KJ. Suppression of the osteogenic response in the aging skeleton. Calcif Tissue Int 1992; 50:306-313.
28. Bass S, Pearce G, Bradney M, et al. Exercise before puberty may confer residual benefits in bone density in adulthood: studies in active prepubertal and retired female gymnasts. J Bone Miner Res 1998;13:500-507.
29. Skerry TM, Lanyon LE. Interruption of disease by short duration walking exercise does not prevent bone loss in sheep calcaneus. Bone 1995;16:269-274.
30. Porr CA, Kronfeld DS, Lawrence LA, et al. Deconditioning reduces mineral content of the third metacarpal bone in horses. J Anim Sci 1998;76:1875-1879.
31. Price JS, Jackson BF, Gray JA, et al. Biochemical markers of bone metabolism in growing thoroughbreds: a longitudinal study. Res Vet Sci 2001;71:37-44.
32. Woitge HW, Scheidt-Nave C, Kissling C, et al. Seasonal variation of biochemical indexes of bone turnover: results of a population based study. J Clin Endocrinol Res 1998;83:68-74.
33. Storm D, Eslin R, Porter ES, et al. Calcium supplementation prevents the seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial. J Clin Endocrinol Metab 1998;83:3817-3825.
34. Jackson BF, Lonnell C, Verheyen K, et al. Gender differences in bone turnover in two year old thoroughbreds. Equine Vet J 2003; 35:in press.
35. Vervuert I, Coenen M, Wedemeyer U, et al. Biochemical markers of bone activity in young standardbred horses during different types of exercise and training. J Vet Med A Physiol Pathol Clin Med 2002;49:396-402.
36. Nielsen BD, Potter GD, Greene LW, et al. Characterization of changes related to mineral balance and bone metabolism in the young racing quarter horse. J Equine Vet Sci 1998;18:190-200.
37. Hiney KM, Potter GD, Gibbs PG, et al. Response of serum biochemical markers of bone metabolism to training in the juvenile racehorse. J Equine Vet Sci 2000;20:851-857.
38. Blumsohn A, Hannon RA, Wrate R, et al. Biochemical markers of bone turnover in girls during puberty. Clin Endocrinol (Oxf) 1994;40:663-670.
39. Hassager C, Jensen LT, Podenphant J, et al. The carboxy-terminal pyridinoline crosslinked telopeptide of type I collagen in serum as a marker of bone resorption. The effect of nandrolone decanoate and hormone replacement therapy. Calcif Tissue Int 1994;54:30-33.
40. Iwamoto J, Takeda T, Ichimura S. Effects of exercise on bone mineral density in mature osteopenic rats. J Bone Miner Res 1998;13:1308-1317.
41. Nikols-Richardson SM, O'Conner PJ, Shapses SA, et al. Longitudinal bone mineral density changes in female child artistic gymnasts. J Bone Miner Res 1999;14:994-1002.
42. Slemenda CW, Peacock M, Hui S, et al. Reduced rates of skeletal remodelling are associated with increased bone mineral density during the development of peak skeletal mass. J Bone Miner Res 1997;12:676-682.
43. Aloia JF, Vaswani A, Yeh JK, et al. Risk for osteoporosis in black women. Calcif Tissue Int 1996;59:415-423.
44. McCarthy RN, Jeffcott LB. Effects of treadmill exercise on cortical bone in the third metacarpus of young horses. Res Vet Sci 1992;52:28-37.
45. Isaksson OGP, Lindahl A, Nilsson A, et al. Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. Endocr Rev 1987;8:426-438.
46. Bautista CM, Mohans S, Baylink DJ. Insulin-like growth factors I and II are present in the skeletal tissues of ten vertebrates. Metabolism 1990;39:96-100.
47. Rawlinson SC, Mohan S, Baylink DJ, et al. Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. Calcif Tissue Int 1993;53:324-329.
48. Zaman G, Suswillo RF, Cheng MZ, et al. Early responses to dynamic strain change and prostaglandins in bone-derived cells in culture. J Bone Miner Res 1997;12:769-777.
49. Hayden JM, Mohan S, Baylink DJ. The insulin-like growth factor system and the coupling of formation to resorption. Bone 1995;17(suppl 2):93S-98S.
50. Nicklas BJ, Ryan A, Treuth MM, et al. Testosterone, growth hormone, and IGF-I response to acute and chronic resistive exercise in men aged 55-70 years. Int J Sports Med 1995;16:445-450.
51. Daly RM, Rich PA, Klein R, et al. Effects of high impact exercise on ultrasonic and biochemical indices of skeletal status: a prospective study in young male gymnasts. J Bone Miner Res 1999; 14:1222-1230.
52. Borst SE, DeHoyos DV, Gazarella L, et al. Effects of resistance training on insulin-like growth factor I and IGF binding proteins. Med Sci Sports Exerc 2001;33:648-653.
53. Davicco MJ, Faulconnier Y, Coxam V, et al. Systemic bone growth factors in light breed mares and their foals. Arch Int Physiol Biochim Biophys 1994;102:115-119.
54. Noble GK, Sillence MN. The potential of mediator hormones as markers of growth hormone abuse in racehorses, in Proceedings. 13th Inter Conf Racing Analysts and Veterinarians 2000;88-90.
55. Price JS, Jackson B, Noble GK, et al. Growth hormone administration increases bone turnover in horses, in Proceedings. 13th Inter Conf Racing Analysts Veterinarians 2000;91-93.
56. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995; 16:3-34.