Valproic acid-induced hearing loss and tinnitus

Internal Medicine

Volumn 42, Issue 11, 2003, Pages 1153-1154

  Hori, Ariyuki ^a   Kataoka, Satoshi ^a   Sakai, Koichiro ^a   Hirose, Genjiro ^a   Iwasaki, Noriko ^a   Horiguchi, Akiko ^a   Takashima, Masayuki ^a   Tomoda, Koichi ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Auditory dysfunction; Hearing loss; Ototoxicity; Valproic acid

Indexed keywords

VALPROIC ACID;

ADULT; ARTICLE; AUDIOGRAPHY; BONE CONDUCTION; CASE REPORT; DRUG BLOOD LEVEL; ELECTROENCEPHALOGRAPHY; FEMALE; GRAND MAL SEIZURE; HEARING IMPAIRMENT; HEARING LOSS; HUMAN; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OTOSCOPY; OTOTOXICITY; PERCEPTION DEAFNESS; PHYSICAL EXAMINATION; SCHOOL CHILD; SEIZURE; TINNITUS; TONIC CLONIC SEIZURE;

EID: 0347513383     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.42.1153     Document Type: Article

References (3)

1. Armon C, Brown E, Carwile S, Miller P, Shin C. Sensorineuronal hearing loss: a reversible effect of valproic acid. Neurology 40: 1896-1898, 1990.
2. McLean MJ, Macdonald RL. Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther 237: 1001-1011, 1986.
3. Franceschetti S, Hamon B, Heinemann U. The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on evoked changes in [Ca2+]o and [K+]o in the hippocampal slice. Brain Res 386: 1-11, 1986.