Adhesion molecule expression by bone marrow CD34-positive cells in aplastic anemia before and after immunosuppressive therapy

Clinical and Laboratory Haematology

Volumn 25, Issue 6, 2003, Pages 393-396

  Kaito, K ^a,b   Otsubo, H ^b   Ogasawara, Y ^b   Shimada, T ^b   Usui, N ^b   Kobayashi, M ^b  

^a JIKEI UNIVERSITY HOSPITAL   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adhesion molecule; Aplastic anemia; Immunosuppressive therapy; Stem cell; Stromal cell

Indexed keywords

ALPHA4 INTEGRIN; CD34 ANTIGEN; CELL ADHESION MOLECULE; CYCLOSPORIN A; GAMMA INTERFERON; STEM CELL FACTOR RECEPTOR; THYMOCYTE ANTIBODY;

ADULT; AGED; APLASTIC ANEMIA; ARTICLE; BONE MARROW CELL; CELL ADHESION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MALE; PATHOGENESIS; PRIORITY JOURNAL; STEM CELL; STROMA CELL; TREATMENT OUTCOME;

ADULT; AGED; ANEMIA, APLASTIC; ANTIGENS, CD34; ANTIGENS, CD95; APOPTOSIS; BONE MARROW; CELL ADHESION; CELL ADHESION MOLECULES; FEMALE; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTEGRIN ALPHA4; INTEGRIN ALPHA5; INTERFERON TYPE II; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-KIT; REMISSION INDUCTION;

EID: 0347504900     PISSN: 01419854     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0141-9854.2003.00552.x     Document Type: Article

References (12)

1. Gordon M.Y., Riley G.P., Watt S.M. & Greaves M.F. (1987) Compartmentalization of a haemopoietic growth factor (GM-CSF) by glycosaminglycans in the bone marrow microenvironment. Nature 326, 403-405.
2. International agranulocytosis and aplastic anemia study (1987) Incidence of aplastic anemia: The relevance of diagnostic criteria. Blood 70, 1718-1721.
3. Kerst J.M., Sanders J.B., Slaper-Cortenbach I.C.M., Doorakkers M.C., Hooibrink B., van Oers R.H.J., von dem Borne A.E.G.K. & van der Schoot C.E. (1993) α4β1 and α5β1 are differentially expressed during myelopoiesis and mediate the adherence of human CD34+ cells to fibronectin in an activation-dependent way. Blood 81, 344-351.
4. Komada H., Nose M., Niida S., Nishikawa S. & Nishikawa S. (1994) Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells. Experimental Hematology 22, 979-984.
5. Levesque J.P., Leavesley D.I., Niutta S., Vadas M. & Simmonds P.J. (1995) Cytokines increase human hematopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins. Journal of Experimental Medicine 181, 1805-1815.
6. Nakao S. (1997) Immune mechanism of aplastic anemia. International Journal of Hematology 66, 127-134.
7. Sealand S., Duvert V., Caux C., Pandrau D., Favre C., Valle A., Durand I., Charbord P., de Vries J. & Banchereau J (1992) Distribution of surface-membrane molecules on bone marrow and cord blood CD34+ hematopoietic cells. Experimental Hematology 20, 24-33.
8. Selleri C., Maciejewski J.P., Sato T. & Young N.S. (1996) Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition. Blood 87, 4149-4157.
9. Sugahara H., Kanakura Y., Furitsu T., Ishihara K., Oritani K. & Ikeda H. (1994) Induction of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5. Journal of Experimental Medicine 179, 1757-1766.
10. Teixido J., Hemler M.E., Greenberg J.S. & Anklesaria P. (1992) Role of β1 and β2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma. Journal of Clinical Investigation 90, 358-367.
11. Turner M.L., McIlwaine K., Anthony R.S. & Parker A.C. (1995) Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood. Stem Cells 13, 311-316.
12. Williams D.A., Rios M., Stephens C. & Patel V.P. (1991) Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature 352, 438-441.