Genetic changes during immortalization of human cells

Radiation Oncology Investigations

Volumn 3, Issue 6, 1995, Pages 299-306

  Reddel, Roger R ^a   Bryan, Tracy M ^a   Rogan, Eileen M ^a   Noble, Jane R ^a   Maclean, Kenneth ^a   Whitaker, Noel J ^a   Chang, Andy C ‐M ^a  

^a CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

immortalization; p16INK4 CDKN2; p53; stanniocalcin; telomerase

Indexed keywords

EID: 0347458424     PISSN: 10657541     EISSN: 15206823     Source Type: Journal    
DOI: 10.1002/roi.2970030610     Document Type: Article

References (28)

1. The serial cultivation of human diploid cell strains
2. SV40‐induced immortalization of human cells
3. SV40‐induced transformation of human diploid cells: Crisis and recovery
4. The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T‐antigen
5. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
6. Telomeres shorten during aging of human fibroblasts
7. The telomere hypothesis of cellular aging
8. Specific association of human telomerase activity with immortal cells and cancer
9. INK4 expression and telomere length during spontaneous immortalization of Li‐Fraumeni syndrome fibroblasts
10. Similar simian virus 40‐induced immortalization frequency of fibroblasts and epithelial cells from human large airways
11. Immortalization of human bronchial epithelial cells
12. Immortalization of human mesothelial cells
13. In vitro transformation of Li‐Fraumeni syndrome fibroblasts by SV40 large T antigen mutants
14. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
15. A novel human cDNA highly homologous to the fish hormone stanniocalcin
16. Germ‐line splicing mutation of the p53 gene in a cancer‐prone family
17. A new regulatory motif in cell‐cycle control causing specific inhibition of cyclin D/CDK4
18. Human papillomavirus type 16 E6 and E7 genes, like simian virus 40 early region genes, are insufficient for immortalization of human mesothelial and bronchial epithelial cells
19. INK4, and telomerase in immortalisation of human cells
20. INK4 in human cancer
21. INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB
22. Ink4 and retinoblastoma tumor‐suppressor genes occur in distinct sub‐sets of human cancer cell lines
23. INK4 expression in primary lung cancers and cell lines
24. Rb alterations in human urothelial cells
25. INK4/MTS1 tumor suppressor gene product
26. Differential display and cloning of messenger RNAs from human breast cancer vs. mammary epithelial cells
27. Telomere elongation in immortal human cells without detectable telomerase activity
28. Genetic analysis of indefinite division in human cells: Identification of four complementation groups