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3142577417
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note
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10(11),12(18) dienone is thermodynamically stable due to its conjuagated cis-diene substructure which is confirmed by its IR.
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27
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3142531074
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note
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(15b) to ensure correct structure determination.
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3142529019
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note
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(a) The 10-acetyl products of compound 6, 8 and 10 are prepared from 10-deacetylbaccatin III, paclitaxel and 7-epi-10-deacetylpaclitaxel respectively by common silylation and acylation. Selective hydrolysis of 10-OAc in these compounds were performed with hydrazine monohydrate in 95% ethanol.
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