Antihypertensive Effect of Enzyme-Treated Zein in Stroke-Prone Spontaneously Hypertensive Rats

Food Science and Technology Research

Volumn 6, Issue 1, 2000, Pages 62-67

  Xu, Xianwei ^a   Ukawa, Yuuichi ^a   Shibata, Masahiko ^b   Umekawa, Hayato ^a   Takahashi, Takao ^a   Doi, Umeyuki ^b   Funatsu, Gunki ^c   Furuichi, Yukio ^a  

^a MIE UNIVERSITY   (Japan)

^b R and D Department   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

ACE inhibitory activity; Proleather; SHRSP; Systolic blood pressure; Thermolysin; Zein

Indexed keywords

EID: 0347368101     PISSN: 13446606     EISSN: None     Source Type: Journal    
DOI: 10.3136/fstr.6.62     Document Type: Article

References (32)

1. Aso, K., Yamashita, M., Arai, S. and Fujimaki, M. (1974). Tryptophan-, threonine-, and lysine-enriched plasteins from zein. Agric. Biol. Chem., 38, 679-680.
2. Chiue, H., Kusano, T. and Iwami, K. (1997). Antioxidative activity of barley hordein and its loss by deamidation. J. Nutr. Sci. Vitaminol., 43, 145-154.
3. Cushman, D.W. and Cheung, H.S. (1971). Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol., 20, 1637-1648.
4. FitzGerald, R.J. and Meisel, H. (1999). Lactokinins: Whey protein-derived ACE inhibitory peptides. Nahrung, 43, 165-167.
5. Fujita, Y., Murakami, Y. and Hayashi, S. (1985). Mechanism for plasma cholesterol-lowering effect of soy protein isolate. Daizu Tanpakushitsu Eiyo Kenkyuukai Kaishi, 4, 85-88 (in Japanese).
6. Higaki, J. and Ogihara, T. (1991). The measures and problems of the renin-angiotensin. Naika, 68, 819-822 (in Japanese).
7. Inada, Y. and Nishikawa, K. (1989). Antihypertensive action and tissue angiotensin converting enzyme inhibitory action of delapril, enalapril and captopril in spontaneously hypertensive rats. Yakuri to Chiryou, 17, 115-123 (in Japanese).
8. Jenkins, W.L., Tovar, L.R., Schwass, D.E., Liardon, R. and Carpenter, K.J. (1984). Nutritional characteristics of alkali-treated zein. J. Agric. Food Chem., 32, 1035-1041.
9. Kim, Y.S., Kim, Y.W. and Sleisenger, M.H. (1974). Studies on the properties of peptide hydrolases in the brush-border and soluble fractions of small intestinal mucosa of rat and man. Biochim. Biophys. Acta, 370, 283-296.
10. Kinoshita, E., Yamakoshi, J. and Kikuchi, M. (1993). Purification and identification of an angiotensin I-converting enzyme inhibitor from soy sauce. Biosci. Biotech. Biochem., 57, 1107-1110.
11. Kohama, Y., Matsumoto, S., Oka, H., Teramoto, T., Okabe, M. and Mimura, T. (1988). Isolation of angiotensin-converting enzyme inhibitor from tuna muscle. Biochem. Biophys. Res. Commun., 155, 332-337.
12. Kokubu, T., Hashimoto, H. and Hiwada, K. (1980). ACE inhibitor. Shindan to Chiryou, 10, 1905-1909 (in Japanese).
13. Maruyama, S. and Suzuki, H. (1982). A peptide inhibitor of angiotensin I converting enzyme in the tryptic hydrolysate of casein. Agric. Biol. Chem., 46, 1393-1394.
14. Maruyama, S., Nakagomi, K., Tomizuka, N. and Suzuki, H. (1985). Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. II. Isolation and bradykinin-potentiating activity on the uterus and the ileum of rats. Agric. Biol. Chem., 49, 1405-1409.
15. Maruyama, S., Miyoshi, S., Kaneko, T. and Tanaka, H. (1989). Angiotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein. Agric. Biol. Chem., 53, 1077-1081.
16. Matsumura, N., Fujii, M., Takeda, Y., Sugita, K. and Shimizu, T. (1993). Angiotensin I-converting enzyme inhibitory peptides derived from bonito bowels autolysate. Biosci. Biotech. Biochem., 57, 695-697.
17. Miyoshi, S., Ishikawa, H., Kaneko, T., Fukui, F., Tanaka, H. and Maruyama, S. (1991a). Structures and activity of angiotensin-converting enzyme inhibitors in an α-zein hydrolysate. Agric. Biol. Chem., 55, 1313-1318.
18. Miyoshi, S., Kaneko, T., Yoshizawa, Y., Fukui, F., Tanaka, H. and Maruyama, S. (1991b). Hypotensive activity of enzymatic α-zein hydrolysate. Agric. Biol. Chem., 55, 1407-1408.
19. Murakami, T., Tsuji, A., Yamamoto, K. and Okamoto, K. (1992). Effects of a fish meal diet initiated at the hypertensive stage on the development of cerebrovascular lesions in SHRSP-Improvement of blood pressure and cerebral stroke lesions, and prolongation of life-span-. Nippon Eiyo Shokuryo Gakkaishi, 45, 129-137 (in Japanese).
20. Murakami, T., Soga, M., Mitsunaga, T., Yoshizumi, H. and Ito, H. (1994). The vascular tissue angiotensin I-converting enzyme activity and aortic elastin content in stroke-prone spontaneously hypertensive rats fed fish diet. Clin. Exp. Pharmacol. Physiol., 21, 453-461.
21. Peters, T.J. (1973). The hydrolysis of glycine oligopeptides by guinea-pig intestinal mucosa and by isolated brush borders. Clin. Sci. Mol. Med., 45, 803-816.
22. Saito, Y., Wanezaki, K., Kawato, A. and Imayasu, S. (1994). Structure and activity of Angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem., 58, 1767-1771.
23. Seki, E., Osajima, K., Matsufuji, H., Matsui, T. and Osajima, Y. (1995). Val-Tyr, an Angiotensin I converting enzyme inhibitor from sardines that has resistance to gastrointestinal proteases. Nippon Nougeikagaku Kaishi, 69, 1013-1020 (in Japanese).
24. Snedecor, G.W. and Cochran, W.G. (1976). In "Statistical Methods, 6th Ed." Iowa State University Press, Ames, pp. 472-503.
25. Sugiyama, K., Takada, K., Egawa, M., Yamamoto, I., Onzuka, H. and Oba, K. (1991). Hypotensive effect of fish protein hydrolysate. Nippon Nougeikagaku Kaishi, 65, 35-43 (in Japanese).
26. Wilson, C.M. (1983). "Seed Proteins: Biochemistry, Genetics, Nutritive Value," ed. by W. Gottschalk and H. P. Muler, Nijhoff, M., Junk, W. Publishers. The Hague, pp. 271.
27. Wilson, C.M. (1987). "Corn: Chemistry and Technology." ed. by S. A. Watson and P. E. Ramstad. American Association of Cereal Chemists. Inc., St. Paul, pp. 273.
28. Wilson, C.M. (1988). Electrophoretic analyses of various commercial and laboratory- prepared zeins. Cereal Chem., 65, 72-73.
29. Yamamoto, N. and Takano, T. (1999). Antihypertensive peptides derived from milk proteins. Nahrung, 43, 159-164.
30. Yamori, Y., Nagaoka, A. and Okamoto, K. (1974). Importance of genetic factors in hypertensive cerebrovascular lesions: Evidence obtained by successive selective breeding of stroke-prone and resistant SHR. Jpn. Circ. J., 38, 1095-1100.
31. Yamori, Y., Horie, R., Tanase, H., Fujiwara, K., Nara, Y. and Lovenberg, W. (1984). Possible role of nutritional factors in the incidence of cerebral lesions in stroke-prone spontaneously hypertensive rats. Hypertension, 6, 49-53.
32. Yano, S., Suzuki, K. and Funatsu, G. (1996). Isolation from α-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci. Biotech. Biochem., 60, 661-663.