Elevated plasma endothelin as an additional cardiovascular risk factor in patients with Cushing's syndrome

European Journal of Endocrinology

Volumn 149, Issue 6, 2003, Pages 549-553

  Kirilov, G ^b   Tomova, A ^b   Dakovska, L ^b   Kumanov, Ph ^b   Shinkov, A ^a   Alexandrov, A S ^a  

^a INSTITUTE OF BIOPHYSICS AND BIOMEDICAL ENGINEERING   (Bulgaria)

^b MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ENDOTHELIN; ENDOTHELIN 1; HYDROCORTISONE;

ADRENAL CORTEX ADENOMA; ADRENALECTOMY; ADULT; AGE; ARTICLE; ATHEROSCLEROSIS; BLOOD LEVEL; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CUSHING SYNDROME; DIAGNOSTIC PROCEDURE; DISEASE SEVERITY; FEMALE; GENDER; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE URINE LEVEL; HYPERCORTISOLISM; MALE; PATHOGENESIS; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STATISTICAL SIGNIFICANCE; TRANSSPHENOIDAL SURGERY; TREATMENT OUTCOME; URINARY EXCRETION;

ADENOMA; ADRENAL GLAND NEOPLASMS; ADULT; CARDIOVASCULAR DISEASES; CUSHING SYNDROME; ENDOTHELIN-1; FEMALE; HUMANS; HYDROCORTISONE; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; REFERENCE VALUES; RISK FACTORS;

EID: 0347359024     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1490549     Document Type: Article

References (21)

1. Haak T, Jungmann E, Haak E, Ehrlich S & Usadel KH. Clinical evidence for a neuromodulator action of endothelin in the hypothalamic-pituitary-adrenal axis in man. Experimental and Clinical Endocrinology and Diabetes 1997 105 46-52.
2. Hinojosa-Laborde C & Lange D. Endothelin regulation of adrenal function. Clinical and Experimental Pharmacology and Physiology 1999 26 995-999.
3. Kiefer F, Kellner M, Jahn H & Wiedemann K. Comparison of the effects of endothelin-1 and -3 on secretion of pituitary hormones in healthy male volunteers. Experimental and Clinical Endocrinology and Diabetes 2000 108 378-381.
4. Nussdorfer GG, Rossi GP, Malendovicz LK & Mazzocchi G. Autocrine-paracrine endothelin system in the physiology and pathology of steroid-secreting tissues. Pharmacological Reviews 1999 51 403-438.
5. Vierhapper H, Novotny P & Waldhausl W. Effect of endothelin-1 in man: impact on basal and adrenocorticotropin-stimulated concentrations of aldosterone. Journal of Clinical Endocrinology and Metabolism 1995 80 948-951.
6. Rossi GP, Belloni AS, Nussdorfer GG & Pessina AC. Endothelin-1 and the adrenal gland. Journal of Cardiovascular Pharmacology 2000 35 (Suppl 2) S17-S20.
7. Hinson J, Cameron LA & Kapas S. Regulation of adrenal vascular tone: role of endothelin-1 and nitric oxide. Endocrine Research 1996 22 875-879.
8. Mazzocchi G, Malendowicz LK, Musajo FG, Gottardo G, Markowska A & Nussdorfer GG. Role of endothelins in regulation of vascular tone in the in situ perfused rat adrenals. American Journal of Physiology. Endocrinology and Metabolism 1998 274 E1-E5.
9. Kelly J, Mangos G, Williamson PM & Whitworth JA. Cortisol and hypertension. Clinical and Experimental Pharmacology and Physiology 1998 25 (Suppl) S51-S56.
10. Letizia C, Centanni M, Scuro L, Canettieri G, Cerci S, De Ciocchis A et al. High plasma levels of endothelin-1 in untreated Addison's disease. European Journal of Endocrinology 1996 135 696-699.
11. Oishi S, Sasaki M & Sato T. Elevated immunoreactive endothelin levels in patients with pheochromocytoma. American Journal of Hypertension 1994 7 717-722.
12. Veglio F, Melchio R, Rabbia F & Chiandussi L. Plasma immunoreactive endothelin-1 in primary hyperaldosteronism. American Journal of Hypertension 1994 7 559-561.
13. Colao A, Pivonello R, Spiezia S, Faggiano A, Ferone D, Filippella M et al. Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. Journal of Clinical Endocrinology and Metabolism 1999 84 2664-2672.
14. Haynes WG & Webb DJ. Endothelin as a regulator of cardiovascular function in health and disease. Journal of Hypertension 1998 16 1081-1098.
15. Haak T, Marz W, Jungmann E, Hausser S, Siekmeier R, Gross W et al. Elevated endothelin levels in patients with hyperlipoproteinemia. Clinical Investigator 1994 72 580-584.
16. Egidy G, Baviera E, Ciuffo G, Corvol P & Pinet F. Localization of the endothelin system in aldosterone-producing adenomas. Hypertension 2001 38 1137-1142.
17. Li Q, Grimelius L, Zhang X, Likinius A, Grondal S, Hoog A et al. Ultrastructural localization of endothelin-1 in nonneoplastic, hyperplastic, and neoplastic adrenal gland. Ultrastructural Pathology 1995 19 489-494.
18. Murakami O, Takahashi K, Sone M, Totsune K, Ohneda M, Itoi K et al. An ACTH-secreting bronchial carcinoid: presence of corticotropin-releasing hormone, neuropeptide Y and endothetin-1 in the tumor tissue. Acta Endocrinologica 1993 128 192-196.
19. Lange M, Pagotto U, Hopfner U, Ehrenreich H, Oeckler R, Sinowatz F et al. Endothelin expression in normal human anterior pituitaries and pituitary adenomas. Journal of Clinical Endocrinology and Metabolism 1994 79 1864-1870.
20. Lange M, Pagotto U, Renner U, Arzberger T, Oeckler R & Stalla GK. The role of endothelins in the regulation of pituitary function. Experimental and Clinical Endocrinology and Diabetes 2002 110 103-112.
21. Ruschitzka F & Luescher T. Endothelin: culprit or bystander in Addison's disease? European Journal of Endocrinology 1996 135 645-648.