Binding of ATP as well as tetrahydrofolate induces conformational changes in Lactobacillus casei folylpolyglutamate synthetase in solution

Biochemistry

Volumn 42, Issue 6, 2003, Pages 1537-1543

  Sheng, Yi ^a   Ip, Hermia ^a   Liu, Jun ^a   Davidson, Alan ^a   Bognar, Andrew L ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BINDING ENERGY; BIOCHEMISTRY; CATALYST ACTIVITY; CHEMICAL ACTIVATION; CONFORMATIONS; CRYSTAL STRUCTURE; MUTAGENESIS; PARAMAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

MUTANTS;

ENZYME KINETICS;

ADENOSINE TRIPHOSPHATE; CYSTEINE; FOLIC ACID; FOLYLPOLYGLUTAMATE SYNTHASE; GLUTAMIC ACID; METHYLENETETRAHYDROFOLIC ACID; MUTANT PROTEIN; PTEROPTIN; SULFONIC ACID DERIVATIVE; TETRAHYDROFOLIC ACID;

ACCELERATION; ADDITION REACTION; AMINO TERMINAL SEQUENCE; ARTICLE; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CIRCULAR DICHROISM; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; ENZYME ACTIVATION; ENZYME BINDING; LACTOBACILLUS CASEI; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; SPECTRUM; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ASPARTIC ACID; CIRCULAR DICHROISM; CYCLIC N-OXIDES; CYSTEINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; LACTOBACILLUS CASEI; LYSINE; MESYLATES; MUTAGENESIS, SITE-DIRECTED; PEPTIDE SYNTHASES; PROTEIN BINDING; PROTEIN CONFORMATION; SOLUTIONS; SPIN LABELS; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATES;

EUKARYOTA; LACTOBACILLUS; LACTOBACILLUS CASEI; POSIBACTERIA;

EID: 0347297576     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi027024y     Document Type: Article

References (21)

1. McGuire, J. J., and Coward, J. K. (1984) in Folates and Pterins (Blakeley, R. L., and Benkovic, S. J., Eds.) pp 135-190, Wiley, New York.
2. Shane, B. (1989) Vitam. Horm. (San Diego) 45, 263-335.
3. Jackman, A. L. Newell, D. R., Jodrell, D. I., Taylor, G. A., Bishop, J. A. M., Hughes, L. R., and Calvert, A. H. (1990) in Chemistry and Biology of Pteridines (Curtius, H. C., Ghisla, S., and Blau, N., Eds.) pp 1023-1026, de Gruyter, Berlin.
4. Sikora, E., Jackman, A. L., Newell, D. R., and Calvert, A. H. (1988) Biochem. Pharmacol. 37, 4074.
5. Kim, J.-S., and Shane, B. (1994) J. Biol. Chem. 269, 9714-9720.
6. Kovacs, J. A., Allegra, C. J., Beaver, C. J., Boarman, D., Lewis, M., Parillo, J., Chabner, B. A., and Mansur, H. (1989) J. Infect. Disease 160, 312-320.
7. Sun, X., Bognar, A. L., Baker, E. N., and Smith, C. A. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 6647-6652.
8. Sun, X., Cross, J. A., Bognar, A. L., Baker, E. N., and Smith, C. A. (2001) J. Mol. Biol. 310, 107-1078.
9. Sheng, Y, Cross, J. A., Smith C. A., and Bognar, A. L. (2002) Arch. Biochem. Biophys. 402, 94-103.
10. Hubbell, W. L., Gross, A., Langen, R., and Lietzow, M. A. (1998) Curr. Opin. Struct. Biol. 8, 649-656.
11. Pace, C. N., Vajdos, F., Fee, L., Grimley, and Gray, T. (1995) Protein Sci. 4, 2411-2423.
12. Shane, B. (1980) J. Biol. Chem. 255, 5655-5662.
13. Fiori, W. R., Miick, S. M., and Millhauser, G.L. (1993) Biochemistry 32, 11957-11962.
14. Farahbakhsh, Z., Huang, Q.-L., Ding L-L., Altenbach, C., Stenhoff, H. J., Horwitz, J., and Hubbell, W. L. (1995) Biochemistry 34, 509-516.
15. Mchaourab, H. S., Oh, K. J., Fang, C. J., and Hubbel, W. L. (1997) Biochemistry 36, 307-316.
16. Shane, B. (1980) J. Biol. Chem. 255, 5663-5667.
17. Bognar, A. L., and Shane, B. (1983) J. Biol. Chem. 258, 12574-12581.
18. Bognar, A. L., Osborne, C., Shane, B., Singer, S., and Ferone, R. (1985) J. Biol. Chem. 260, 5625-5630.
19. Bognar, A. L., and Shane, B. (1986) Methods Enzymol. 122, 349-359.
20. Cichowicz, D. J., and Shane, B. (1987) Biochemistry 26, 513-521.
21. Andreassi, J. L., and Moran, R. G. (2002) Biochemistry 41, 226-235.