Gene therapy for human immunodeficiency virus infection in the humanized SCID mouse model

Israel Medical Association Journal

Volumn 5, Issue 12, 2003, Pages 863-867

  Touraine, Jean Louis ^a   Sanhadji, Kamel ^a   Sembeil, Rachel ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

CD4 immunoadhesin; Gene therapy; Human immunodeficiency virus; Interferon; SCID hu mice; Tat and Rev mutants

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD4 IMMUNOGLOBULIN; GAMMA INTERFERON; INTERFERON; MONOCLONAL ANTIBODY 2F5; REV PROTEIN; RNA DIRECTED DNA POLYMERASE; TRANSACTIVATOR PROTEIN; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CELL LEVEL; CELL LINE; CELL STRAIN 3T3; CELL STRAIN U937; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG SOLUBILITY; ENZYME INHIBITION; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMA; SCID MOUSE; VIRUS INHIBITION; VIRUS LOAD;

ANIMALS; CD4 IMMUNOADHESINS; DISEASE MODELS, ANIMAL; GENE THERAPY; GENES, REV; GENES, TAT; HIV INFECTIONS; HUMANS; INTERFERONS; MICE; MICE, SCID; RNA-DIRECTED DNA POLYMERASE; TRANSFORMATION, GENETIC;

EID: 0347288598     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Sanhadji K, Leissner P, Firouzi R, et al. Experimental gene therapy: The transfer of Tat-inducible interferon genes protects human cells against HIV-1 challenge in vitro and in vivo in severe combined immunodeficient mice. AIDS 1997;11:977-86.
2. Sanhadji K, Grave L, Touraine JL, et al. Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice. AIDS 2000;14:2813-22.
3. Sorg T, Leissner P, Calenda V, et al. Therapie genique des maladies infectieuses: Le modele du SIDA. Med Sci 1996;12:13-24.
4. Poluri A, Maanem MW, Sutton RE. Genetic therapy for HIV/AIDS. Expert Opin Biol 2003;3:951-63.
5. Deeks SG, Wagner B, Anton PA, et al. A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Mol Ther 2002;5:788-97.
6. Schwartz O, Henin Y, Marechal V, Montagnier L. A rapid and simple colorimetric test for the study of anti-HIV agents. AIDS Res Hum Retroviruses 1998;3:441-8.
7. Sambrook J, Fritsch EF, Maniatis T. In: Nolan C, ed. Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory, 1989.
8. Coccia EM, Krust B, Hovanessian AG. Specific inhibition of viral protein synthesis in HIV infected cells in response to interferon treatment. J Biol Chem 1994;269:23087-94.
9. Hansen BD, Nara PL, Maheshwari RK. Loss of infectivity by progeny virus from alpha interferon-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gp 120. J Virol 1992;66:7543-8.
10. Ho D, Avidon UN, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-6.
11. Muster T, Guinea R, Trkola A, et al. Cross-neutralization activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS. J Virol 1994;68:4031-4.
12. Valere T, Bohl D, Klatzmann D, Danos O, Sonigo P, Heard JM. Continuous secretion of human soluble CD4 in mice transplanted with genetically modified cells. Gene Ther 1995;2:197-202.
13. Kahn JO, Alla JD, Hodges TL, Kaplan LD, Arri CJ, Fitch HF. The safety and pharmacokinetics of recombinant soluble CD4 (rCD4) in subjects with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase 1 study (comments). Ann Intern Med 1990;112:254-61.
14. Shinya E, Dervillez X, Edwards-Levy F, et al. In vivo delivery of therapeutic proteins by genetically modified cells: Comparison or organoids and human serum albumin alginate-coated beads. Biomed Pharmacother 1999;53:471-83.
15. Ranga U, Woffendin C, Verma S, et al. Enhancement of T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals. Proc Natl Acad Sci USA 1998;95:1201-6.