New Nucleoside Conjugates with Phospholipids: Synthesis and Anti-HIV Activity of rac-1-Hexadecyl-2-acyl-sn-glycero-3-phosphonucleosides

Bioorganicheskaya Khimiya

Volumn 23, Issue 8, 1997, Pages 653-654

  Malekin, S I ^a   Kruglyak, Yu L ^a   Khromova, N Yu ^a   Aksenova, M Yu ^a   Sokolov, V P ^a   Kisin, A V ^a   Novozhilova, T I ^a   Popova, S G ^a   Kurochkin, V K ^a   Miller, G G ^b   Pokidysheva, L N ^b  

^a STATE RESEARCH INSTITUTE OF ORGANIC CHEMISTRY AND TECHNOLOGY   (Russian Federation)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

1 alkyl 2 acylglycerol; Anti HIV activity; Glycerophosphate; Hemolysis; Nucleoside; Phospholipid

Indexed keywords

2',3' O ISOPROPYLIDENE URIDINE; 2',3'-O-ISOPROPYLIDENE URIDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DRUG DERIVATIVE; NUCLEOSIDE; PHOSPHOLIPID; STAVUDINE; THYMINE; URIDINE;

ARTICLE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENZYME IMMUNOASSAY; ERYTHROCYTE; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; HYDROLYSIS; METABOLISM; SYNTHESIS; VIRUS REPLICATION;

ANTI-HIV AGENTS; ERYTHROCYTES; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; HYDROLYSIS; IMMUNOENZYME TECHNIQUES; NUCLEOSIDES; PHOSPHOLIPIDS; STAVUDINE; THYMINE; URIDINE; VIRUS REPLICATION;

EID: 0347173690     PISSN: 01323423     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Hosteller K.Y., Stuhmiller L.M., Lenting H.B.M., van den Bosch H., Richman D.D. // J. Biol. Chem. 1990. V. 265. P. 6112-6117.
2. Steim I.M., Neto C.C., Sarin P.S., Sun D.K., Sehgal R.K., Turcoffe J.G. // Biochem. Biophys. Res. Commun. 1990. V. 171. P. 451-457.
3. Piantadosi C., Marasco C.J., Morris-Nataschke S.L., Meyer K.L., Gumus F., Surles J.R., Ishaq K.S., Kucera L.S., Iyer N., Wallen C.A., Piantadosi S., Modest E.I. // J. Med. Chem. 1991. V. 34. P. 1408-1414.
4. Brockerhoff H., Ayengar N.K.N. // Lipids. 1979. V. 14. P. 88-89.
5. Surles J.R., Marx M.H., Piantadosi C. // J. Org. Chem. 1988. V. 53. P. 899-901.
6. Hong C.I., An S.H., Buchheit D.J., Nechaev A., Kirisits A.I., West C.R., Berdel W.E. // J. Med. Chem. 1986. V. 29. P. 2038-2044
7. Lindh I., Stawinski I. // J. Org. Chem. 1989. V. 54. P. 1338-1342.
8. Kessel D. // J. Biol. Chem. 1968. V. 243. P. 4739.
9. Kerr S.G., Kaiman T.J. // J. Med. Chem. 1992. V. 35. P. 1996-2001.
10. Matsuzaki K., Handa T., Miyajima K., Mikura Y., Shimizu H., Toguchi H. // Chem. Pharm. Bull. 1988. V. 36. P. 4253-4260.
11. Mar A., Michl H. // Toxicon. 1976. V. 14. P. 191-195.
12. McConnell R.L., Coower H.W. // J. Org. Chem. 1959. V. 24. P. 630-635.
13. Mansuri M.M., Starrett J.E., Ghazzouli I., Hitchcock M.J.M., Sterzycki R.Z., Brankovan V., Lin T.-S., August E.M., Prusoff W.H., Sommadossi I.-P., Martin J.C. // J. Med. Chem. 1989. V. 32. P. 461-466.
14. Vaskovsky V.E., Svetashev V.I. // J. Chromatogr. 1972. V. 65. P. 451.
15. Miyoschi I., Kabamoto L., Tokana I. // Nature. 1981. V. 294. P. 770-771.
16. Miller G.G., Bykovsky A.Ph., Pokidysheva L.N., Titova I.V. // VIII Int. Conf. AIDS, V. 3. Amsterdam, 1992. P. 29.