Hyperkalemic hyperchloremic metabolic acidosis: Pathophysiologic insights

Kidney International

Volumn 51, Issue 2, 1997, Pages 591-602

  DuBose Jr , Thomas D ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; AMMONIA; BICARBONATE; CYCLOSPORIN A; MINERALOCORTICOID; PENTAMIDINE; POLYSTYRENESULFONATE SODIUM; SPIRONOLACTONE; TRIAMTERENE; TRIMETHOPRIM;

ACID BASE BALANCE; ADULT; ARTICLE; CASE REPORT; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERCHLOREMIC ACIDOSIS; HYPERKALEMIA; METABOLIC ACIDOSIS; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; SYMPTOMATOLOGY;

EID: 0347082456     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.85     Document Type: Article

References (76)

1. WRIGHT FS, GIEBISCH G: Regulation of potassium excretion, in The Kidney, Physiology and Pathophysiology, edited by SELDIN DW, GIEBISCH G, New York, Raven Press, 1992, p 2209
2. WEST ML, MARSDEN PA, RICHARDSON MA, ZETTLE RM, HALPERIN ML: New clinical approach to evaluate disorders of potassium excretion. Miner Electrol Metab 12:234-238, 1986
3. WEST ML, BENDZ O, CHEN CB, SINGER GG, RICHARDSON RMA, SONNENBERG H, HALPERIN ML: Development of a test to evaluate the transtubular potassium concentration gradient in the cortical collecting duct in vivo. Miner Electrol Metab 12:226-233, 1986
4. KAMEL KS, ETHIER JH, QUAGGIN S, LEVIN A, ALBERT S, CARLISLE EJF, HALPERIN M: Studies to determine the basis for hyperkalemia in recipients of a renal transplant who are treated with cyclosporine. J Am Soc Nephrol 2:1279-1284, 1991
5. SAJO IM, GOLDSTEIN MB, SONNENBERG H, SAJO IM, GOLDSTEIN MB, SONNENBERG H, STEINBAUGH BJ, WILSON DR, HALPERIN ML: Sites of ammonia production to tubular fluid in rats with chronic metabolic acidosis. Kidney Int 20:353-358, 1981
6. GOOD DW, BURG MB: Ammonia production by individual segments of the rat nephron. J Clin Invest 63:602-610, 1984
7. GOOD DW, DUBOSE TD JR: Ammonia transport by early and late proximal convoluted tubule of the rat. J Clin Invest 79:689-691, 1987
8. HWANG J-J, CURTHOYS NP: Effect of acute alterations in acid-base balance on rat renal glutaminase and phosphoenolpyruvate carboxykinase gene expression. J Biol Chem 266:9392-9396, 1991
9. KAISER S, CURTHOYS NP: Effect of pH and bicarbonate on phosphoenolpyruvate carboxykinase and glutaminase on mRNA levels in cultured renal epithelial cells. J Biol Chem 266:9397-9407, 1991
10. + exchanger. Am J Physiol 241: C220-C226, 1981
11. NAGAMI GT, SONU CM, KUROKAWA K: Ammonia production by isolated mouse proximal tubule perfused in vitro. Effect of metabolic acidosis. J Clin Invest 78:124-129, 1986
12. HAMM LL, TRIGG D, MARTIN D, GILLESPIE C, BUERKERT J: Transport of ammonia in the rabbit collecting tubule. J Clin Invest 75:478-485, 1985
13. + transport by rabbit renal proximal straight tubules. Am J Physiol 21:F232-F239, 1987
14. 3 proximal tubules. Role in ammonia and bicarbonate transport. J Clin Invest 78:989-996, 1986
15. DUBOSE TD JR, LUCCI MS, HOGG RJ, PUCACCO LR, KOKKO JP, CARTER NW: Comparison of acidification parameters in superficial and deep nephrons of the rat. Am J Physiol 244:F497-F503, 1983
16. GOOD DW, KNEPPER MA, BURG MB: Ammonia and bicarbonate transport by thick ascending limb of rat kidney. Am J Physiol 247:F35-F44, 1984
17. GOOD DW: Ammonium transport by the thick ascending limb of Henle's loop. Ann Rev Physiol 56:623-647, 1994
18. + transport. J Gen Physiol 103:917-936, 1994
19. + channel II. Cloning and distribution of alternative forms. Am J Physiol 268 (Renal Fluid Electrol Physiol 37):F1132-F1140, 1995
20. DUBOSE TD JR, GOOD DW: Role of the thick ascending limb and inner medullary collecting duct in the regulation of urinary acidification. Semin Nephrol 11:120-128, 1991
21. GOOD DW, CAFLISCH DR, DUBOSE TD JR: Transepithelial ammonia concentration gradients in inner medulla of the rat. Am J Physiol 252:F491-F500, 1987
22. + augments net acid secretion by a ouabain-sensitive mechanism in isolated perfused inner medullary collecting ducts. Am J Physiol 270 (Renal Fluid Electrol Physiol) 39:F432-F439, 1996
23. DUBOSE TD JR, GOOD DW, HAMM LL, WALL SM: Ammonium transport in the kidney: New physiologic concepts and their clinical implications. J Am Soc Nephrol 1:1193-1203, 1991
24. GOLDSTEIN MB, BEAR R, RICHARDSON RMA, MARSDEN PA, HALPERIN ML: The urine anion gap: A clinically useful index of ammonium excretion. Am J Med Sci 292:198-202, 1986
25. CARLISLE EJF, DONNELLY SM, HALPERIN ML: Renal tubular acidosis (RTA): Recognize the ammonium defect and pHorget the urine pH. Pediatr Nephrol 5:242-246, 1991
26. DUBOSE TD JR, GOOD DW: Effects of chronic hyperkalemia on renal production and proximal tubule transport of ammonium in the rat. Am J Physiol 260:F680-F687, 1991
27. DUBOSE TD JR, GOOD DW: Chronic hyperkalemia impairs ammonium transport and accumulation in the inner medulla of the rat. J Clin Invest 90:1443-1449, 1992
28. DUBOSE TD JR, GOOD DW: Effects of chronic chloride depletion metabolic alkalosis on proximal tubule transport and renal production of ammonium. Am J Physiol 269 (Renal Fluid Electrol Physiol 38):F508-F514, 1995
29. + by rat medullary thick ascending limb. Am J Physiol 255 (Renal Fluid Electrol Physiol 38):F78-F87, 1988
30. 2 gradient as an index of distal nephron acidification in experimental models of distal renal tubular acidosis. J Clin Invest 75:1116-1123, 1985
31. DUBOSE TD JR, CAFLSCH CR: Effect of selective aldosterone deficiency on acidification in nephron segments of the rat inner medulla. J Clin Invest 82:1624-1632, 1988
32. HUSTED RF, STEINMETZ PR: The effects of amiloride and ouabain on urinary acidification by turtle bladder. J Pharmacol Exp Ther 210:264-268, 1979
33. DUBOSE TD JR: Experimental models of distal renal tubular acidosis. Semin Nephrol 10:174-179, 1990
34. LASKI ME, KURTZMAN NA: Characterization of acidification in the cortical and medullary collecting tubule of the rabbit. J Clin Invest 72:2050-2059, 1983
35. SABATINI S, KURTZMAN NA: Enzyme activity in obstructive uropathy: The biochemical basis for salt wastage and the acidification defect. Kidney Int 37:79-84, 1990
36. + ATPase following acute unilateral ureteral obstruction in rats. Am J Physiol 261:F365-F376, 1991
37. 3 production in mineralocorticoid-deficient glucocorticoid-replete dogs. Am J Physiol 326:F136-F146, 1979
38. + transport by aldosterone in turtle urinary bladder. J Clin Invest 58:351-358, 1976
39. SEBASTIAN A, SUTTON JM, HULTER HN, SCHAMBELAN M, POLER SM: Effect of mineralocorticoid replacement therapy on renal acid-base homeostasis in adrenalectomized patients. Kidney Int 18:762-769, 1980
40. SZYLMAN P, BETTER OS, CHAIMOWITZ C, ROSLER A: Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism. N Engl J Med 294:361-365, 1975
41. SEBASTIAN A, SCHAMBELAN M, LINDENFELD S, MORRIS RC JR: Amelioration of metabolic acidosis with fludrocortisone therapy in hyporeninemic hypoaldosteronism. N Engl J Med 297:576-582, 1977
42. SCHAMBELAN M, SEBASTIAN A, BIGLIERI EG: Prevalence, pathogenesis, and functional significance of aldosterone deficiency in hyperkalemic patients with chronic renal insufficiency. Kidney Int 17:89-94, 1980
43. DEFRONZO RA: Nephrology Forum: Hyperkalemia and hyporeninemic hypoaldosteronism. Kidney Int 17:118-134, 1980
44. DUBOSE TD JR, COGAN MG, RECTOR FC JR: Acid-base disorders, in The Kidney (5th ed), edited by BRENNER BM, RECTOR FC JR, Philadelphia, Saunders, 1995, p 929
45. OETLIKER OH, ZURBRUGG RP: Renal tubular acidosis in salt-losing syndrome of congenital adrenal hyperplasia (CAH). J Clin Endocrinol Metab 31:447-450, 1970
46. WEIDMAN P, REINHART R, MAXWELL MH, ROWE P, COBURN JW, MASSRY SG: Syndrome of hyporeninemic hypoaldosteronism and hyperkalemia in renal disease. J Clin Endocrinol Metab 36:965-977, 1973
47. OH MS, CARROL HJ, CLEMMONS JE, VAGNUCCI AH, LEVISON SP, WHANG ESM: A mechanism for hyporeninemic hypoaldosteronism in chronic renal disease. Metabolism 23:1157-1166, 1974
48. DAVENPORT MW, ZIPSER RD: Association of hypotension with hyperreninemic hypoaldosteronism in the critically ill patient. Arch Intern Med 143:735-737, 1983
49. ANTONIPILLAI I, WANG Y, HORTON R: Tumor necrosis factor and interleukin-1 may regulate renin secretion. Endocrinology 126:273-278, 1990
50. O'KELLY R, MAGEE F, MCKENNA TF: Routine heparin therapy inhibits adrenal aldosterone production. J Clin Endocrinol Metab 56:108-112, 1983
51. ARMANINI D, KUHALE U, STRASSER T, DORR H, BUTENANDT I, WEBER PC, STOCKIGT JR, PEARCH P, FUNDER JW: Aldosterone receptor deficiency in pseudohypoaldosteronism. N Engl J Med 313: 1178-1183, 1985
52. CHANG SS, GRUNDER S, HANAKOGLU A, ROSLER A, MATHEW PM, HANUKOGLU I, SCHILD L, LU Y, SHIMKETS RA, NELSONWILLIAMS C, ROSSIER BC, LIFTON RP: Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalemic acidosis, pseudohypoaldosteronism type 1. Nat Genet 12:248-253, 1996
53. SCHAMBELAN M, SEBASTIAN A, RECTOR FC JR: Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): Role of increased renal chloride reabsorption. Kidney Int 19:716-727, 1981
54. SIMON DB, FARFEL Z, ELLISON D, BIA M, TUCCI J, LIFTON RP: Examination of the thiazide-sensitive Na-Cl cotransporter as a candidate gene in Gordon's syndrome. J Am Soc Nephrol 6:632A, 1995
55. RODRIGUEZ-SORIANO J, VALLO A, QUINTELA MJ, OLIVEROS R, UBETAGOYENE M: Normokalemic pseudohypoaldosteronism is present in children with acute pyelonephritis. Acta Pediatr 81:402-406, 1992
56. DUBOSE TD JR, ALPERN R: Renal tubular acidosis, in The Metabolic Basis of Inherited Disease (7th ed), edited by SCRIVER CR, BEAUDET AL, SLY WS, VALLE D, New York, McGraw-Hill, 1995, p 3655
57. MEHTA BR, CAVALLO T, REMMERS AR JR, DUBOSE TD JR: Hyporeninemic hypoaldosteronism in a patient with multiple myeloma. Am J Kidney Dis 4:175-178, 1984
58. BATLLE DC: Segmental characterization of defects in collecting tubule acidification. Kidney Int 30:546-554, 1986
59. PONCE SP, JENNINGS AE, MADIAS NE, HARRINGTON JT: Drug-induced hyperkalemia. Medicine 64:357-370, 1985
60. KLEYMAN TR, ROBERTS C, LING BN: A mechanism for pentamidine-induced hyperkalemia: Inhibition of distal nephron sodium transport. Ann Intern Med 122:103-106, 1995
61. + channels in A6 distal nephron cells. Kidney Int 45:1070-1076, 1994
62. VALAZQUEZ H, PERAZELLA MN, WRIGHT FS, ELLISON DH: Renal mechanisms of trimethoprim-induced hyperkalemia. Ann Intern Med 1193:296-301, 1993
63. KAMEL KS, ETHIER JH, QUAGGIN S, LEVIN A, ALBERT S, CARLISLE EJF, HALPERIN ML: Studies to determine the basis of hyperkalemia in recipients of a renal transplant who are treated with cyclosporine. J Am Soc Nephrol 2:1279-1284, 1991
64. +-ATPase activity by FK506 involves calcineurin. Kidney Int 46:647-652, 1994
65. BANTLE JP, NATH KA, SUTHERLAND ER, NAJARIAN JS, FERRIS TF: Effects of cyclosporine on the renin-angiotensin-aldosterone system and potassium excretion in renal transplant recipients. Arch Intern Med 145:505-508, 1985
66. AGUILERA S, DERAY G, DESJOBERTT H, BENHMIDA M, HOANG PL, JACOBS C: Effects of cyclosporine on tubular acidification function in patients with idiopathic uveitis. Am J Nephrol 12:425-430, 1992
67. 3 -cotransporter by angiotensin II in rabbit renal cortex. Am J Physiol 265:F195-F203, 1993
68. NAGAMI GT: Effect of luminal angiotensin II on ammonia production and secretion by mouse proximal tubules. Am J Physiol 269:F86-F92, 1995
69. SZYLMAN P, BETTER OS, CHAIMOVITZ C, ROSLER A: Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism. N Engl J Med 294:361-365, 1976
70. SCHAMBELAN M, SEBASTIAN A: Hyporeninemic hypoaldosteronism. Adv Intern Med 24:385, 1978
71. LEVEL M, GROSE JH: Angiotensin II effect on plasma steroids in selective hypoaldosteronism. Horm Metab Res 14:432-436, 1982
72. WILLIAMS GH: Hyporeninemic hypoaldosteronism. N Engl J Med 314:1041, 1986
73. NATH KA, HOSTETTER MK, HOSTETTER TH: Pathophysiology of chronic tubulo-interstitial disease in rats. J Clin Invest 76:667-675, 1985
74. ALPERN RJ: Nephrology Forum: Trade-offs in the adaptation to acidosis. Kidney Int 47:1205-1215, 1995
75. PHELPS KR, OH MS, CARROLL HJ: Heparin-induced hyperkalemia. Report of a case. Nephron 25:254, 1980
76. SHERMAN RA, RUDDY MC: Suppression of aldosterone production by low-dose heparin. Am J Nephrol 6:165, 1986