Homing to Nonlymphoid Tissues Is Not Necessary for Effector Th1 Cell Differentiation

Journal of Immunology

Volumn 171, Issue 12, 2003, Pages 6355-6362

  Bajénoff, Marc ^a   Guerder, Sylvie ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CYTOKINE; GAMMA INTERFERON; HEN EGG LYSOZYME; INTERLEUKIN 12; LYSOZYME; T LYMPHOCYTE RECEPTOR;

ANIMAL; ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIGEN SPECIFICITY; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL MOTION; CELL SURVIVAL; CYTOLOGY; EDEMA; EFFECTOR CELL; EXTERNAL EAR; GENETICS; HINDLIMB; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE MIGRATION; LYMPHOID ORGAN; LYMPHOID TISSUE; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOLOGY; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN; SKIN SENSITIZATION; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TRANSGENIC MOUSE;

EID: 0346996714     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.12.6355     Document Type: Article

References (37)

1. + T cell clonal expansion. J. Immunol. 168:1682.
2. Iezzi, G., K. Karjalainen, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity. 8:89.
3. Jelley-Gibbs, D. M., N. M. Lepak, M. Yen, and S. L. Swain. 2000. Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen-dependent and late cytokine-driven expansion and differentiation. J. Immunol. 165:5017.
4. Bird, J. J., D. R. Brown, A. C. Mullen, N. H. Moskowitz, M. A. Mahowald, J. R. Sider, T. F. Gajewski, C. R. Wang, and S. L. Reiner. 1998. Helper T cell differentiation is controlled by the cell cycle. Immunity 9:229.
5. + T cells. J. Immunol. 168:1723.
6. Murphy, K. M., W. Ouyang, S. J. Szabo, N. G. Jacobson, M. L. Guler. J. D. Gorham, U. Gubler, and T. L. Murphy. 1999. T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases. Curr. Top. Microbiol. Immunol. 238:13.
7. Grogan, J. L., M. Mohrs, B. Harmon, D. A. Lacy, J. W. Sedat, and R. M. Locksley. 2001. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 14:205.
8. Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:655.
9. Mullen, A. C., F. A. High, A. S. Hutchins, H. W. Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T. P. Yao. S. Y. Yang, and S. L. Reiner. 2001. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292:1907.
10. Lighvani, A. A., D. M. Frucht, D. Jankovic, H. Yamane, J. Aliberti, B. D. Hissong, B. V. Nguyen, M. Gadina, A. Sher, W. E. Paul. and J. J. O'Shea. 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98:15137.
11. + T cells. Nat. Immun. 3:549.
12. Szabo, S., A. Dighe, U. Gubler, and K. Murphy. 1997. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817.
13. Grogan, J. L., and R. M. Locksley. 2002. T helper cell differentiation: on again, off again. Curr. Opin. Immunol. 14:366.
14. + T cells. J. Immunol. 159:591.
15. Wang, X., and T. Mosmann. 2001. In vivo priming of CD4 T cells that produce interleukin (IL)-2 but not IL-4 or interferon (IFN)-γ and can subsequently differenfiate into IL-4- or IFN-γ-secreting cells. J. Exp. Med. 194:1069.
16. Campbell, D. J., C. H. Kim, and E. C. Butcher. 2001. Separable effector T cell populations specialized for B cell help or tissue inflammation. Nat. Immun. 2:876.
17. + T cells. J. Exp. Med. 179:1539.
18. Schon, M. P., A. Arya, E. A. Murphy, C. M. Adams, U. G. Strauch, W. W. Agace, J. Marsal, J. P. Donohue, H. Her, D. R. Beier, et al. 1999. Mucosal T lymphocyte numbers are selectively reduced in integrin αE (CD103)-deficient mice. J. Immunol. 162:6641.
19. Roman, E., E. Miller, A. Harmsen, J. Wiley, U. H. Von Andrian, G. Huston, and S. L. Swain. 2002. CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J. Exp. Med. 196:957.
20. Gudmundsdottir, H., A. D. Wells, and L. A. Turka. 1999. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J. Immunol. 162:5212.
21. Hirata, T., G. Merrill-Skoloff, M. Aab, J. Yang, B. C. Furie, and B. Furie. 2000. P-selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. J. Exp. Med. 192:1669.
22. + T cells migrate into inflamed skin only if they express ligands for E- and P-selectin. J. Immunol. 161:963.
23. Reinhardt, R. L., A. Khoruts, R. Merica. T. Zell, and M. K. Jenkins. 2001. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410:101.
24. Dustin, M. L., and T. A. Springer. 1989. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341:619.
25. + T cells. J. Immunol. 162:696.
26. Issekutz, A. C., and T. B. Issekutz. 2002. The role of E-selectin, P-selectin, and very late activation antigen-4 in T lymphocyte migration to dermal inflammation. J. Immunol. 168:1934.
27. Santamaria Babi, L. F., R. Moser, M. T. Perez Soler, L. J. Picker, K. Blaser, and C. Hauser. 1995. Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1). J. Immunol. 154:1543.
28. Austrup, F., D. Vestweber, E. Borges, M. Lohning, R. Brauer, U. Herz, H. Renz, R. Hallmann, A. Scheffold, A. Radbruch, and A. Hamann. 1997. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 385:81.
29. Borges, E., W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, and D. Vestweber. 1997. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J. Exp. Med. 185:573.
30. Pendl, G. G., C. Robert, M. Steinert, R. Thanos, R. Eytner, E. Borges, M. K. Wild, J. B. Lowe, R. C. Fuhlbrigge, T. S. Kupper, et al. 2002. Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1. Blood 99:946.
31. Zhang, X., T. Brunner, L. Carter, R. W. Dutton, P. Rogers, L. Bradley, T. Sato, J. C. Reed, D. Green, and S. L. Swain. 1997. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185:1837.
32. Wu, C. Y., J. R. Kirman, M. J. Rotte, D. F. Davey, S. P. Perfetto. E. G. Rhee, B. L. Freidag, B. J. Hill, D. C. Douek, and R. A. Seder. 2002. Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo. Nat. Immun. 3:852.
33. Kearney, E., K. Pape, D. Loh, and M. Jenkins. 1994. Visualization of peptide-specific cell immunity and peripheral tolerance induction in vivo. Immunity 1:327.
34. + T cells to the lung airways during respiratory virus infections. J. Immunol. 170:1423.
35. + T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function. J. Immunol. 167:2019.
36. + memory T cell subsets in persistent EBV infection are differentiated by migratory receptor expression. Eur. J. Immunol. 30:1823.
37. Wherry, E. J., V. Teichgraber, T. C. Becker, D. Masopust, S. M. Kaech, R. Antia, U. H. Von Andrian, and R. Ahmed. 2003. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immun. 4:225.